Search Results - "Finney, Joel"

Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design by Finney, Joel, Kelsoe, Garnett

“…A central puzzle in HIV-1 research is the inability of vaccination or even infection to reliably elicit humoral responses against broadly neutralizing epitopes…”
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Minding the gap: The impact of B‐cell tolerance on the microbial antibody repertoire by Finney, Joel, Watanabe, Akiko, Kelsoe, Garnett, Kuraoka, Masayuki

“…B lymphocytes must respond to vast numbers of foreign antigens, including those of microbial pathogens. To do so, developing B cells use combinatorial joining…”
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MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasive in Vitro by Moon, Hee-Jung, Finney, Joel, Xu, Li, Moore, David, Welch, Danny R., Mure, Minae

“…LOXL2 is a copper- and lysine tyrosylquinone-dependent amine oxidase that has been proposed to function both extracellularly and intracellularly to activate…”
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Post-translational Modifications of Recombinant Human Lysyl Oxidase-like 2 (rhLOXL2) Secreted from Drosophila S2 Cells by Xu, Li, Go, Eden P., Finney, Joel, Moon, HeeJung, Lantz, Mason, Rebecchi, Kathryn, Desaire, Heather, Mure, Minae

“…Human lysyl oxidase-like 2 (hLOXL2) is highly up-regulated in metastatic breast cancer cells and tissues and induces epithelial-to-mesenchymal transition, the…”
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Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2 by Finney, Joel, Kelsoe, Garnett

“…Stable, long-term culture of primary B lymphocytes has many potential scientific and medical applications, but remains an elusive feat. A major obstacle to…”
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Ideal Vaccines: Balancing B Cell Recruitment and Differentiation by Finney, Joel, Kelsoe, Garnett

“…In this issue of Immunity, Kato et al. show that high-affinity vaccines targeting rare B cells capable of broadly protective antibody responses are not…”
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Human copper-dependent amine oxidases by Finney, Joel, Moon, Hee-Jung, Ronnebaum, Trey, Lantz, Mason, Mure, Minae

“…•Human TPQ-containing CAOs and LOX(L)s are reviewed.•Mechanisms of cofactor biogenesis and oxidation of amine substrates are described.•The relevance of these…”
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Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity by Okada, Kazushi, Moon, Hee-Jung, Finney, Joel, Meier, Alex, Mure, Minae

“…Overexpression of lysyl oxidase-like 2 (LOXL2) is associated with several hepatic and vascular fibrotic diseases and tumor progression in some aggressive…”
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Human lysyl oxidase-like 2 by Moon, Hee-Jung, Finney, Joel, Ronnebaum, Trey, Mure, Minae

“…[Display omitted] •The structure and functions of human lysyl oxidase-like 2 (LOXL2) are reviewed.•Hypotheses for cofactor biogenesis and the role of Cu2+ are…”
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Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells by Yeh, Chen-Hao, Finney, Joel, Okada, Takaharu, Kurosaki, Tomohiro, Kelsoe, Garnett

“…T follicular helper (Tfh) cells are defined by a Bcl6+CXCR5hiPD-1hi phenotype, but only a minor fraction of these reside in germinal centers (GCs). Here, we…”
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Germinal center responses to complex antigens by Finney, Joel, Yeh, Chen‐Hao, Kelsoe, Garnett, Kuraoka, Masayuki

“…Summary Germinal centers (GCs) are the primary sites of antibody affinity maturation, sites where B‐cell antigen‐receptor (BCR) genes rapidly acquire mutations…”
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Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5 by Finney, Joel, Yang, Guang, Kuraoka, Masayuki, Song, Shengli, Nojima, Takuya, Verkoczy, Laurent, Kitamura, Daisuke, Haynes, Barton F, Kelsoe, Garnett

“…2F5 is an HIV-1 broadly neutralizing Ab that also binds the autoantigens kynureninase (KYNU) and anionic lipids. Generation of 2F5-like Abs is proscribed by…”
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Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin by Finney, Joel, Moseman, Annie Park, Kong, Susan, Watanabe, Akiko, Song, Shengli, Walsh, Jr, Richard M, Kuraoka, Masayuki, Kotaki, Ryutaro, Moseman, E Ashley, McCarthy, Kevin R, Liao, Dongmei, Liang, Xiaoe, Nie, Xiaoyan, Lavidor, Olivia, Abbott, Richard, Harrison, Stephen C, Kelsoe, Garnett

“…Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies…”
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WITHDRAWN: PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity by Okada, Kazushi, Moon, Hee-Jung, Finney, Joel, Couture, Frédéric, Day, Robert, Mure, Minae

“…This article has been withdrawn by the authors. Figs 1C, 2A, and 2E contained some inadvertently mislabeled data. The authors state that the mislabeling does…”
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Fate Decisions During B-Lymphocyte Development and Activation by Finney, Joel Thomas

“…Understanding B-lymphocyte fate specification during B-cell development and humoral responses is important for developing vaccines and tools for studying B…”
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Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5 hi PD-1 hi T follicular helper cells by Yeh, Chen-Hao, Finney, Joel, Okada, Takaharu, Kurosaki, Tomohiro, Kelsoe, Garnett

“…T follicular helper (Tfh) cells are defined by a Bcl6 CXCR5 PD-1 phenotype, but only a minor fraction of these reside in germinal centers (GCs). Here, we…”
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How Tolerance Shapes the Development of the HIV-1 Broadly Neutralizing Antibody 2F5 by Finney, Joel T, Yang, Guang, Kuraoka, Masayuki, Nojima, Takuya, Verkoczy, Laurent, Kitamura, Daisuke, Haynes, Barton F, Kelsoe, Garnett H

“…Abstract An effective HIV-1 vaccine is likely to require induction of broadly neutralizing antibodies (bnAbs), which neutralize multiple HIV-1 strains…”
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