Search Results - "Finnefrock, Adam C."

Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine by Freed, Daniel C, Tang, Qi, Tang, Aimin, Li, Fengsheng, He, Xi, Huang, Zhao, Meng, Weixu, Xia, Lin, Finnefrock, Adam C, Durr, Eberhard, Espeseth, Amy S, Casimiro, Danilo R, Zhang, Ningyan, Shiver, John W, Wang, Dai, An, Zhiqiang, Fu, Tong-Ming

“…Human cytomegalovirus (HCMV) can cause serious morbidity/mortality in transplant patients, and congenital HCMV infection can lead to birth defects. Developing…”
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Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria by Armistead, Jennifer S, Morlais, Isabelle, Mathias, Derrick K, Jardim, Juliette G, Joy, Jaimy, Fridman, Arthur, Finnefrock, Adam C, Bagchi, Ansu, Plebanski, Magdalena, Scorpio, Diana G, Churcher, Thomas S, Borg, Natalie A, Sattabongkot, Jetsumon, Dinglasan, Rhoel R

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Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus by Fu, Tong-Ming, Wang, Dai, Freed, Daniel C, Tang, Aimin, Li, Fengsheng, He, Xi, Cole, Suzanne, Dubey, Sheri, Finnefrock, Adam C, ter Meulen, Jan, Shiver, John W, Casimiro, Danilo R

“…Highlights ► Early vaccines miss a pentameric gH complex important for viral epithelial entry. ► We restored expression of the complex in AD169 virus for…”
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Quantitative analysis of neutralizing antibody response to human cytomegalovirus in natural infection by Wang, Dai, Li, Fengsheng, Freed, Daniel C, Finnefrock, Adam C, Tang, Aimin, Grimes, Shannon N, Casimiro, Danilo R, Fu, Tong-Ming

“…Highlights ► Natural cytomegalovirus infection in healthy women induces potent neutralizing antibodies against infection of both fibroblasts and epithelial…”
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PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination by Finnefrock, Adam C, Tang, Aimin, Li, Fengsheng, Freed, Daniel C, Feng, Meizhen, Cox, Kara S, Sykes, Kara J, Guare, James P, Miller, Michael D, Olsen, David B, Hazuda, Daria J, Shiver, John W, Casimiro, Danilo R, Fu, Tong-Ming

“…Programmed Cell Death 1 (PD-1) plays a crucial role in immunomodulation. Binding of PD-1 to its ligand receptors down-regulates immune responses, and published…”
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Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody by Krauss, Isaac J, Joyce, Joseph G, Finnefrock, Adam C, Song, Hong C, Dudkin, Vadim Y, Geng, Xudong, Warren, J. David, Chastain, Michael, Shiver, John W, Danishefsky, Samuel J

“…Di- and trivalent glycopeptide mimics of the HIV 2G12 epitope have been synthesized and evaluated for their comparative 2G12 binding characteristics. The…”
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Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study by Li, Fusheng, Finnefrock, Adam C, Dubey, Sheri A, Korber, Bette T M, Szinger, James, Cole, Suzanne, McElrath, M Juliana, Shiver, John W, Casimiro, Danilo R, Corey, Lawrence, Self, Steven G

“…T cell directed HIV vaccines are based upon the induction of CD8+ T cell memory responses that would be effective in inhibiting infection and subsequent…”
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Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates by Bianchi, Elisabetta, Joyce, Joseph G, Miller, Michael D, Finnefrock, Adam C, Liang, Xiaoping, Finotto, Marco, Ingallinella, Paolo, McKenna, Philip, Citron, Michael, Ottinger, Elizabeth, Hepler, Robert W, Hrin, Renee, Nahas, Deborah, Wu, Chengwei, Montefiori, David, Shiver, John W, Pessi, Antonello, Kim, Peter S

“…Eliciting a broadly neutralizing polyclonal antibody response against HIV-1 remains a major challenge. One approach to vaccine development is prevention of…”
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Tolerability of Two Sequential Electroporation Treatments Using MedPulser DNA Delivery System (DDS) in Healthy Adults by Wallace, Mark, Evans, Barbara, Woods, Sandra, Mogg, Robin, Zhang, Lei, Finnefrock, Adam C, Rabussay, Dietmar, Fons, Michael, Mallee, John, Mehrotra, Devan, Schödel, Florian, Musey, Luwy

“…Immunotherapy against infectious agents and malignant tumors requires efficient priming of effector cells through direct expression and/or efficient…”
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A Re-Evaluation of the Morphology of a Bicontinuous Block Copolymer−Ceramic Material by Toombes, Gilman E. S, Finnefrock, Adam C, Tate, Mark W, Ulrich, Ralph, Wiesner, Ulrich, Gruner, Sol M

“…The structures of a poly(isoprene-block-ethylene oxide) (PI-b-PEO) block copolymer-directed aluminosilicate mesostructure and the resulting ceramic material…”
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Selection and Characterization of Murine Monoclonal Antibodies to Staphylococcus aureus Iron-Regulated Surface Determinant B with Functional Activity In Vitro and In Vivo by Brown, Martha, Kowalski, Rose, Zorman, Julie, Wang, Xin-Min, Towne, Victoria, Zhao, Qinjian, Secore, Susan, Finnefrock, Adam C, Ebert, Tim, Pancari, Greg, Isett, Kevin, Zhang, Yuhua, Anderson, Annaliesa S, Montgomery, Donna, Cope, Leslie, McNeely, Tessie

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An efficient T-cell epitope discovery strategy using in silico prediction and the iTopia assay platform by Fridman, Arthur, Finnefrock, Adam C., Peruzzi, Daniela, Pak, Irene, La Monica, Nicola, Bagchi, Ansuman, Casimiro, Danilo R., Ciliberto, Gennaro, Aurisicchio, Luigi

“…Functional T-cell epitope discovery is a key process for the development of novel immunotherapies, particularly for cancer immunology. In silico epitope…”
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Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A01-Negative Rhesus Monkeys by Liang, Xiaoping, Casimiro, Danilo R, Schleif, William A, Wang, Fubao, Davies, Mary-Ellen, Zhang, Zhi-Qiang, Fu, Tong-Ming, Finnefrock, Adam C, Handt, Larry, Citron, Michael P, Heidecker, Gwendolyn, Tang, Aimin, Chen, Minchun, Wilson, Keith A, Gabryelski, Lori, McElhaugh, Michael, Carella, Anthony, Moyer, Cheryl, Huang, Lingyi, Vitelli, Salvatore, Patel, Deepa, Lin, Jing, Emini, Emilio A, Shiver, John W

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A replication-defective human cytomegalovirus vaccine for prevention of congenital infection by Wang, Dai, Freed, Daniel C, He, Xi, Li, Fengsheng, Tang, Aimin, Cox, Kara S, Dubey, Sheri A, Cole, Suzanne, Medi, Muneeswara Babu, Liu, Yaping, Xu, Jingyuan, Zhang, Zhi-Qiang, Finnefrock, Adam C, Song, Liping, Espeseth, Amy S, Shiver, John W, Casimiro, Danilo R, Fu, Tong-Ming

“…Congenital human cytomegalovirus (HCMV) infection occurs in ~0.64% of infants born each year in the United States and is the leading nongenetic cause of…”
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Pairwise antibody footprinting using surface plasmon resonance technology to characterize human papillomavirus type 16 virus-like particles with direct anti-HPV antibody immobilization by Towne, Victoria, Zhao, Qinjian, Brown, Martha, Finnefrock, Adam C.

“…This paper describes an approach to surface plasmon resonance (SPR) based epitope mapping, also referred to as pairwise antibody footprinting, involving the…”
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Development of neutralizing monoclonal antibodies for oncogenic human papillomavirus types 31, 33, 45, 52, and 58 by Brown, Martha J, Seitz, Hanna, Towne, Victoria, Müller, Martin, Finnefrock, Adam C

“…Human papillomavirus (HPV) is the etiological agent for all cervical cancers, a significant number of other anogenital cancers, and a growing number of head…”
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Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41 by Montgomery, Donna L., Wang, Ying-Jie, Hrin, Renee, Luftig, Micah, Su, Bin, Miller, Michael D., Wang, Fubao, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Condra, Jon, Liu, Xiaomei, Hampton, Richard, Carfi, Andrea, Pessi, Antonello, Bianchi, Elisabetta, Joyce, Joseph, Lloyd, Chris, Geleziunas, Romas, Bramhill, David, King, Vicki M., Finnefrock, Adam C., Strohl, William, An, Zhiqiang

“…The human D5 monoclonal antibody binds to the highly conserved hydrophobic pocket on the N-terminal heptad repeat (NHR) trimer of HIV-1 gp41 and exhibits…”
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Reflectance imaging spectroscopy and synchrotron radiation X-ray fluorescence mapping used in a technical study of The Blue Room by Pablo Picasso by Favero, Patricia A., Mass, Jennifer, Delaney, John K., Woll, Arthur R., Hull, Alyssa M., Dooley, Kathryn A., Finnefrock, Adam C.

“…The existence of a portrait hidden beneath The Blue Room (1901) by Pablo Picasso prompted a comprehensive technical study of this early Blue period painting…”
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Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag by CASIMIRO, Danilo R, FUBAO WANG, BAGCHI, Ansu, TUSSEY, Lynda G, BETT, Andrew J, FINNEFROCK, Adam C, FU, Tong-Ming, AIMIN TANG, WILSON, Keith A, MINCHUN CHEN, PERRY, Helen C, HEIDECKER, Gwendolyn J, SCHLEIF, William A, FREED, Daniel C, CARELLA, Anthony, PUNT, Kara S, SYKES, Kara J, LINGYI HUANG, AUSENSI, Virginia I, BACHINSKY, Margaret, SADASIVAN-NAIR, Usha, WATKINS, David I, EMINI, Emilio A, XIAOPING LIANG, SHIVER, John W, ZHANG, Zhi-Qiang, TOBERY, Timothy W, DAVIES, Mary-Ellen, MCDERMOTT, Adrian B, O'CONNOR, David H, FRIDMAN, Arthur

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A novel high-throughput neutralization assay for supporting clinical evaluations of human cytomegalovirus vaccines by Tang, Aimin, Li, Fengsheng, Freed, Daniel C, Finnefrock, Adam C, Casimiro, Danilo R, Wang, Dai, Fu, Tong-Ming

“…Highlights ► We developed a neutralizing assay for measuring antiviral activity against CMV. ► This assay format is no longer relying on virus induced…”
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