Search Results - "Finnberg, Niklas K."

Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity by Finnberg, Niklas K, Gokare, Prashanth, Navaraj, Arunasalam, Lang Kuhs, Krystle A, Cerniglia, George, Yagita, Hideo, Takeda, Kazuyoshi, Motoyama, Noboru, El-Deiry, Wafik S

“…The combination of TRAIL death receptor agonists and radiochemotherapy to treat advanced cancers continues to be investigated in clinical trials. We previously…”
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Detection of DSS-induced gastrointestinal mucositis in mice by non-invasive optical near-infrared (NIR) imaging of cathepsin activity by Finnberg, Niklas K, Liu, Yvette, El-Deiry, Wafik S

“…Approximately 1.4 million people of the US population suffer from Inflammatory Bowel Disease (IBD) of which the most common conditions are ulcerative colitis…”
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Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients by Kline, Christina Leah, Sheikh, Hassan S., Scicchitano, Angelique, Gingrich, Rebecca, Beachler, Cheryl, Finnberg, Niklas K., Liao, Jason, Sivik, Jeffrey, El-Deiry, Wafik S.

“…Efforts to improve efficacy and minimize toxicity have led to pharmacokinetic monitoring of plasma 5-Fluorouracil (5-FU) levels in colorectal cancer patients…”
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Targeting TRAIL in the treatment of cancer: new developments by Lim, Bora, Allen, Joshua E, Prabhu, Varun V, Talekar, Mala K, Finnberg, Niklas K, El-Deiry, Wafik S

“…While apoptosis is critical for maintaining homeostasis in normal cells, defective apoptosis contributes to the survival of cancer cells. TNF-related…”
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Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures by Finnberg, Niklas K, Gokare, Prashanth, Lev, Avital, Grivennikov, Sergei I, MacFarlane, 4th, Alexander W, Campbell, Kerry S, Winters, Ryan M, Kaputa, Karen, Farma, Jeffrey M, Abbas, Abbas El-Sayed, Grasso, Luigi, Nicolaides, Nicholas C, El-Deiry, Wafik S

“…We have developed 3D-tumoroids and tumor slice culture systems from surgical tumor specimens derived from patients with colorectal cancer (CRC) or lung cancer…”
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Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC) by Abdulghani, Junaid, Gokare, Prashanth, Gallant, Jean-Nicolas, Dicker, David, Whitcomb, Tiffany, Cooper, Timothy, Liao, Jiangang, Derr, Jonathan, Liu, Jing, Goldenberg, David, Finnberg, Niklas K, El-Deiry, Wafik S

“…Anaplastic thyroid cancer (ATC) comprises approximately 2% of all thyroid cancers, and its median survival rate remains poor. It is responsible for more than…”
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Occurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient by Regan, Samuel, Yang, Xuebin, Finnberg, Niklas K, El-Deiry, Wafik S, Pu, Jeffrey J

“…Hydroxyurea (HU) has been widely used in sickle cell disease. Its potential long-term risk for carcinogenesis or leukemogenic risk remains undefined. Here, we…”
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P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting by Gokare, Prashanth, Finnberg, Niklas K., Abbosh, Phillip H., Dai, Jenny, Murphy, Maureen E., El-Deiry, Wafik S.

“…Nucleotide metabolism in cancer cells can influence malignant behavior and intrinsic resistance to therapy. Here we describe p53-dependent control of the…”
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Tissue TGF-β expression following conventional radiotherapy and pulsed low-dose-rate radiation by Meyer, Joshua E, Finnberg, Niklas K, Chen, Lili, Cvetkovic, Dusica, Wang, Bin, Zhou, Lanlan, Dong, Yanqun, Hallman, Mark A, Ma, Chang-Ming C, El-Deiry, Wafik S

“…The release of inflammatory cytokines has been implicated in the toxicity of conventional radiotherapy (CRT). Transforming growth factor β (TGF-β) has been…”
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Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons by Gokare, Prashanth, Navaraj, Arunasalam, Zhang, Shengliang, Motoyama, Noboru, Sung, Shen-Shu, Finnberg, Niklas K

“…The DNA damage response (DDR) gene cell cycle checkpoint kinase 2 (Chk2) triggers programmed cell death and lethal radiation-induced toxicity in mice in vivo…”
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The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo by Kuribayashi, Kageaki, Finnberg, Niklas K., Jeffers, John R., Zambetti, Gerard P., El-Deiry, Wafik S.

“…The p53 pathway displays a large degree of redundancy in the expression of a number of pro-apoptotic mechanisms following DNA damage that, among others,…”
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Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the Apcmin/+ mouse model by Madka, Venkateshwar, De La Cruz, Arielle, Pathuri, Gopal, Panneerselvam, Janani, Zhang, Yuting, Stratton, Nicole, Hacking, Sean, Finnberg, Niklas K, Safran, Howard P, Sei, Shizuko, Glaze, Elizabeth R, Shoemaker, Robert, Fox, Jennifer T, Raufi, Alexander G, El-Deiry, Wafik S, Rao, Chinthalapally V

“…Colorectal cancer (CRC) incidence is rising globally. Hence, preventing this disease is a high priority. With this aim, we determined the CRC prevention…”
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TRAIL death receptors as tumor suppressors and drug targets by Finnberg, Niklas K., El-Deiry, Wafik S.

“…Various ways of targeting TRAIL-death receptors for the treatment of a diverse set of malignancies are being explored in ongoing clinical trials. Recent data…”
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PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features by Teye, Emmanuel K, Sido, Abigail, Xin, Ping, Finnberg, Niklas K, Gokare, Prashanth, Kawasawa, Yuka I, Salzberg, Anna C, Shimko, Sara, Bayerl, Michael, Ehmann, W Christopher, Claxton, David F, Rybka, Witold B, Drabick, Joseph J, Wang, Hong-Gang, Abraham, Thomas, El-Deiry, Wafik S, Brodsky, Robert A, J Hohl, Raymond, Pu, Jeffrey J

“…Previous studies have linked increased frequency of glycosylphosphatidylinositol-anchor protein (GPI-AP) deficiency with genomic instability and the risk of…”
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High-Resolution Imaging and Antitumor Effects of GFP+ Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors by Finnberg, Niklas K, Hart, Lori S, Dolloff, Nathan G, Rodgers, Zachary B, Dicker, David T, El-Deiry, Wafik S

“…Bone marrow-derived cells (BMDCs) participate in the growth and spread of tumors of the breast, brain, lung, and stomach. To date, there are limited reports of…”
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Abstract 5636: Targeting of NOXA overexpression in anaplastic thyroid cancer (ATC) by Finnberg, Niklas K., Abdulghani, Junaid, Ehya, Hormoz, El-Deiry, Wafik

“…Abstract Anaplastic thyroid cancer (ATC) is a rare, aggressive and fatal cancer with a median survival of 3-5 months after diagnosis. Our long-term goal is to…”
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Abstract 14: TRAIL inducing small molecule ONC201 prevents intestinal tumors in FAP mouse model by Rao, Chinthalapally V., Madka, Venkateshwar, Zhang, Yuting, Pathuri, Gopal, Panneerselvam, Janani, Stratton, Nicole, Finnberg, Niklas K., Safran, Howard P., Fox, Jennifer, Sei, Shizuko, Glaze, Elizabeth R., Shoemaker, Robert, El-Deiry, Wafik S.

“…Abstract Colorectal cancer (CRC) is a major health problem globally. Preventing CRC in the general population, and especially in high-risk cohorts with colonic…”
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Abstract 5713: PIGN gene expression aberration weakens chromosomal stability via altering its interaction with the spindle assembly checkpoint protein complex during leukemogenesis by Pu, Jeffrey J., Teye, Emmanuel K., Sido, Abigail, Kawasawa, Yuka I., Xin, Ping, Finnberg, Niklas K., El-Deiry, Wafik S., Shimko, Sara

“…Abstract Previous studies have linked increased frequency of glycosylphosphatidylinositol-anchor protein (GPI-AP) deficiency with genomic instability and the…”
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Abstract 3990: Use of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures by Finnberg, Niklas K., Gokare, Prashanth, Lev, Avital, MacFarlane, Alexander W., Campbell, Kerry S., Kaputa, Karen, Farma, Jeffrey, Grasso, Luigi, Nicolaides, Nicholas C., El-Deiry, Wafik

“…Abstract Historically, the successful establishment of exponentially growing viable in vitro tumor cell cultures has been found to occur from a minority of…”
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Sorafenib and quinacrine target anti-apoptotic protein Mcl-1: a poor prognostic marker in anaplastic thyroid cancer (ATC) by Abdulghani, Junaid, Gokare, Prashanth, Gallant, Jean-Nicolas, Dicker, David, Whitcomb, Tiffany, Cooper, Timothy, Liao, Jiangang, Derr, Jonathan, Liu, Jing, Goldenberg, David, Finnberg, Niklas K., El-Deiry, Wafik S.

“…The drug combination of sorafenib and quinacrine targets Mcl-1 and triggers synergistic responses in difficult to treat anaplastic thyroid cancer cells thereby…”
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