Search Results - "Finn, Kenneth J"

Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification by Green, Brian M, Finn, Kenneth J, Li, Joachim J

“…Eukaryotic cells use numerous mechanisms to ensure that no segment of their DNA is inappropriately re-replicated, but the importance of this stringent control…”
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MicroRNA silencing through RISC recruitment of eIF6 by Liebhaber, Stephen A, Ji, Xinjun, Chendrimada, Thimmaiah P, Gregory, Richard I, Pasquinelli, Amy E, Baillat, David, Shiekhattar, Ramin, Finn, Kenneth J

“…MicroRNAs (miRNAs) are a class of small RNAs that act post-transcriptionally to regulate messenger RNA stability and translation. To elucidate how miRNAs…”
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Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination by Finn, Kenneth J, Li, Joachim J

“…Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution,…”
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A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism by Marina, Diana B, Shankar, Smita, Natarajan, Prashanthi, Finn, Kenneth J, Madhani, Hiten D

“…Long noncoding RNAs (lncRNAs) can trigger repressive chromatin, but how they recruit silencing factors remains unclear. In Schizosaccharomyces pombe,…”
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A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells by Finn, Kenneth J, Martin, Scott E, Settleman, Jeff

“…Despite the remarkable clinical efficacy demonstrated by molecularly targeted cancer therapeutics, the benefits are typically temporary due to the emergence of…”
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Trapping of a nonpeptide ligand by the extracellular domains of the gonadotropin-releasing hormone receptor results in insurmountable antagonism by Kohout, Trudy A, Xie, Qiu, Reijmers, Shelby, Finn, Kenneth J, Guo, Zhiqiang, Zhu, Yun-Fei, Struthers, R Scott

“…Drugs that exhibit insurmountable antagonism are proposed to provide improved clinical efficacy through extended receptor blockade. Long-term suppression of…”
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Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination. e1003192 by Finn, Kenneth J, Li, Joachim J

“…Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution,…”
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MicroRNA silencing through RISC recruitment of elF6 by CHENDRIMADA, Thimmaiah P, FINN, Kenneth J, XINJUN JI, BAILLAT, David, GREGORY, Richard I, LIEBHABER, Stephen A, PASQUINELLI, Amy E, SHIEKHATTAR, Ramin

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