Search Results - "Finlin, Brian S."

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans by Finlin, Brian S, Memetimin, Hasiyet, Zhu, Beibei, Confides, Amy L, Vekaria, Hemendra J, El Khouli, Riham H, Johnson, Zachary R, Westgate, Philip M, Chen, Jianzhong, Morris, Andrew J, Sullivan, Patrick G, Dupont-Versteegden, Esther E, Kern, Philip A

“…BACKGROUNDBeige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this…”
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Improved β-cell function leads to improved glucose tolerance in a transgenic mouse expressing lipoprotein lipase in adipocytes by Memetimin, Hasiyet, Zhu, Beibei, Lee, Sangderk, Katz, Wendy S., Kern, Philip A., Finlin, Brian S.

“…Lipoprotein lipase (LPL) hydrolyzes the triglyceride core of lipoproteins and also functions as a bridge, allowing for lipoprotein and cholesterol uptake…”
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The Effects of Temperature and Seasons on Subcutaneous White Adipose Tissue in Humans: Evidence for Thermogenic Gene Induction by Kern, Philip A, Finlin, Brian S, Zhu, Beibei, Rasouli, Neda, McGehee, Robert E, Westgate, Philip M, Dupont-Versteegden, Esther E

“…Context: Although brown adipose tissue (BAT) activity is increased by a cold environment, little is known of the response of human white adipose tissue (WAT)…”
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Macrophages expressing uncoupling protein 1 increase in adipose tissue in response to cold in humans by Finlin, Brian S., Memetimin, Hasiyet, Confides, Amy L., Zhu, Beibei, Westgate, Philip M., Dupont-Versteegden, Esther E., Kern, Philip A.

“…Acute cold induces beige adipocyte protein marker expression in human subcutaneous white adipose tissue (SC WAT) from both the cold treated and contralateral…”
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Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity by Spencer, Michael, Yang, Lin, Adu, Akosua, Finlin, Brian S, Zhu, Beibei, Shipp, Lindsey R, Rasouli, Neda, Peterson, Charlotte A, Kern, Philip A

“…Adipose tissue in insulin resistant subjects contains inflammatory cells and extracellular matrix components. This study examined adipose pathology of insulin…”
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The RGK family of GTP-binding proteins: Regulators of voltage-dependent calcium channels and cytoskeleton remodeling by Correll, Robert N., Pang, Chunyan, Niedowicz, Dana M., Finlin, Brian S., Andres, Douglas A.

“…RGK proteins constitute a novel subfamily of small Ras-related proteins that function as potent inhibitors of voltage-dependent (VDCC) Ca 2+ channels and…”
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Regulation of Voltage-Gated Calcium Channel Activity by the Rem and Rad GTPases by Finlin, Brian S., Crump, Shawn M., Satin, Jonathan, Andres, Douglas A.

“…Rem, Rem2, Rad, and Gem/Kir (RGK) represent a distinct GTPase family with largely unknown physiological functions. We report here that both Rem and Rad bind…”
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Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism by Finlin, Brian S, Memetimin, Hasiyet, Zhu, Beibei, Confides, Amy L, Vekaria, Hemendra J, El Khouli, Riham H, Johnson, Zachary R, Westgate, Philip M, Chen, Jianzhong, Morris, Andrew J, Sullivan, Patrick G, Dupont-Versteegden, Esther E, Kern, Philip A

“…BACKGROUNDBeige and brown adipose tissue (BAT) are associated with improved metabolic homeostasis. We recently reported that the β3-adrenergic receptor agonist…”
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The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans by Finlin, Brian S, Zhu, Beibei, Kok, Bernard P, Godio, Cristina, Westgate, Philip M, Grayson, Neile, Sims, Robert, Bland, Jeffrey S, Saez, Enrique, Kern, Philip A

“…In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and…”
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Effect of Rifaximin Treatment on Endotoxemia and Insulin Sensitivity in Humans by Finlin, Brian S, Zhu, Beibei, Boyechko, Tania, Westgate, Philip M, Chia, Chee W, Egan, Josephine M, Kern, Philip A

“…The gut microbiome is a source of inflammatory factors such as lipopolysaccharide (LPS; endotoxin) that influence metabolic homeostasis. Rifaximin is a…”
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Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by the Rem2 GTPase by Finlin, Brian S., Mosley, Amber L., Crump, Shawn M., Correll, Robert N., Özcan, Sabire, Satin, Jonathan, Andres, Douglas A.

“…Voltage-dependent calcium (Ca2+) channels are involved in many specialized cellular functions and are controlled by a diversity of intracellular signals…”
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Plasma Membrane Targeting Is Essential for Rem-mediated Ca2+ Channel Inhibition by Correll, Robert N., Pang, Chunyan, Finlin, Brian S., Dailey, Alexandria M., Satin, Jonathan, Andres, Douglas A.

“…The small GTPase Rem is a potent negative regulator of high voltage-activated Ca2+ channels and a known interacting partner for Ca2+ channel accessory β…”
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Sphk2−/− mice are protected from obesity and insulin resistance by Ravichandran, Shwetha, Finlin, Brian S., Kern, Philip A., Özcan, Sabire

“…Sphingosine kinases phosphorylate sphingosine to sphingosine 1‑phosphate (S1P), which functions as a signaling molecule. We have previously shown that…”
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Mast Cells Promote Seasonal White Adipose Beiging in Humans by Finlin, Brian S, Zhu, Beibei, Confides, Amy L, Westgate, Philip M, Harfmann, Brianna D, Dupont-Versteegden, Esther E, Kern, Philip A

“…Human subcutaneous (SC) white adipose tissue (WAT) increases the expression of beige adipocyte genes in the winter. Studies in rodents suggest that a number of…”
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Human skeletal muscle macrophages increase following cycle training and are associated with adaptations that may facilitate growth by Walton, R. Grace, Kosmac, Kate, Mula, Jyothi, Fry, Christopher S., Peck, Bailey D., Groshong, Jason S., Finlin, Brian S., Zhu, Beibei, Kern, Philip A., Peterson, Charlotte A.

“…Skeletal muscle macrophages participate in repair and regeneration following injury. However, their role in physiological adaptations to exercise is…”
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Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance by SPENCER, Michael, FINLIN, Brian S, CAMPBELL, Marilyn, MCGEHEE, Robert E, PETERSON, Charlotte A, KERN, Philip A, UNAL, Resat, ZHU, Beibei, MORRIS, Andrew J, SHIPP, Lindsey R, LEE, Jonah, GRACE WALTON, R, ADU, Akosua, ERFANI, Rod

“…Fish oils (FOs) have anti-inflammatory effects and lower serum triglycerides. This study examined adipose and muscle inflammatory markers after treatment of…”
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Human adipose beiging in response to cold and mirabegron by Finlin, Brian S, Memetimin, Hasiyet, Confides, Amy L, Kasza, Ildiko, Zhu, Beibei, Vekaria, Hemendra J, Harfmann, Brianna, Jones, Kelly A, Johnson, Zachary R, Westgate, Philip M, Alexander, Caroline M, Sullivan, Patrick G, Dupont-Versteegden, Esther E, Kern, Philip A

“…The induction of beige adipocytes in s.c. white adipose tissue (WAT) depots of humans is postulated to improve glucose and lipid metabolism in obesity. The…”
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Aldose reductase promotes diet‐induced obesity via induction of senescence in subcutaneous adipose tissue by Thiagarajan, Devi, Quadri, Nosirudeen, Jawahar, Shabnam, Zirpoli, Hylde, Pozo, Carmen Hurtado, López‐Díez, Raquel, Hasan, Syed Nurul, Yepuri, Gautham, Gugger, Paul F., Finlin, Brian S., Kern, Philip A., Gabbay, Kenneth, Schmidt, Ann Marie, Ramasamy, Ravichandran

“…Objective Aldose reductase (AKR1B1 in humans; Akr1b3 in mice), a key enzyme of the polyol pathway, mediates lipid accumulation in the murine heart and liver…”
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Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation by Pang, Chunyan, Crump, Shawn M., Jin, Ling, Correll, Robert N., Finlin, Brian S., Satin, Jonathan, Andres, Douglas A.

“…The Rem, Rem2, Rad, and Gem/Kir (RGK) GTPases, comprise a subfamily of small Ras-related GTP-binding proteins, and have been shown to potently inhibit high…”
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Adipose Tissue Mast Cells Promote Human Adipose Beiging in Response to Cold by Finlin, Brian S., Confides, Amy L., Zhu, Beibei, Boulanger, Mary C., Memetimin, Hasiyet, Taylor, Kyle W., Johnson, Zachary R., Westgate, Philip M., Dupont-Versteegden, Esther E., Kern, Philip A.

“…In a recent study, repeated cold application induced beiging in subcutaneous white adipose tissue (SC WAT) of humans independent of body mass index. To…”
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