Search Results - "Finlay, M. Ray V."

Abstract 4744: Structure-based development of covalent inhibitors of the activating and T790M gatekeeper mutant forms of the epidermal growth factor receptor (EGFR) leading to the discovery of AZD9291 by Ward, Richard A., Ashton, Susan, Anderton, Mark, Ballard, Pete G., Bradbury, Rob H., Butterworth, Sam, Colclough, Nicola, Cross, Darren A E, Finlay, M Ray V., McFarland, Heather L., Mellor, Martine, Waring, Mike J.

“…Abstract Small molecule inhibitors of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase such as gefitinib and erlotinib have been employed…”
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Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells by Nicolaou, K. C., Vourloumis, Dionisios, Li, Tianhu, Pastor, Joaquin, Winssinger, Nicolas, He, Yun, Ninkovic, Sacha, Sarabia, Francisco, Vallberg, Hans, Roschangar, Frank, King, N. Paul, Finlay, M. Ray V., Giannakakou, Pareskevi, Verdier-Pinard, Pascal, Hamel, Ernest

“…A library of epothilone A and B analogues, which was constructed by solid‐phase combinatorial synthesis using SMART Microreactors and solution chemistry, was…”
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Probing the Ring Size of Epothilones: Total Synthesis of [14]-, [15]-, [17]-, and [18]Epothilones A by Nicolaou, K. C., Sarabia, Francisco, Ninkovic, Sacha, Finlay, M. Ray V., Boddy, Christopher N. C.

“…Unfamiliar rings. The pharmocophore of epothilone A does not tolerate changes in ring size. The 14‐, 15‐, 17‐, and 18‐membered ring analogues 1 (n = 1, 2, 4,…”
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Total synthesis of 26-hydroxy-epothilone B and related analogs via a macrolactonization based strategy by Nicolaou, K.C., Finlay, M.Ray V., Ninkovic, Sacha, Sarabia, Francisco

“…The chemical synthesis of a series of 26-substituted epothilones B is described. Fully protected 26-hydroxydesoxy-epothilone B ( 7), prepared via the…”
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Chemistry, biology and medicine of selected tubulin polymerizing agents by Nicolaou, K. C., Hepworth, David, King, N. P., Finlay, M. R. V.

“…Abstract…”
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Variation der Ringgröße von Epothilonen – Totalsynthese von [14]‐, [15]‐, [17]‐ und [18]Epothilon A by Nicolaou, K. C., Sarabia, Francisco, Ninkovic, Sacha, Finlay, M. Ray V., Boddy, Christopher N. C.

“…Kaum tolerant gegenüber Änderungen der Ringgröße ist das Pharmakophor des Epothilons A: Die 14‐, 15‐, 17‐ und 18gliedrigen Ringanaloga 1 (n = 1, 2, 4 bzw. 5)…”
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Gezielt entworfene Epothilone: kombinatorische Synthese, Induktion der Tubulin‐Polymerisation und cytotoxische Wirkung gegen taxolresistente Tumorzellen by Nicolaou, Kyriacos Costa, Vourloumis, Dionisios, Li, Tianhu, Pastor, Joaquin, Winssinger, Nicolas, He, Yun, Ninkovic, Sacha, Sarabia, Francisco, Vallberg, Hans, Roschanger, Frank, King, N. Paul, Finlay, M. Ray V., Giannakakou, Pareskevi, Verdier‐Pinard, Pascal, Hamel, Ernest

“…Eine Bibliothek von Epothilon‐A und ‐B‐Analoga, die durch kombinatorische Festphasensynthese mit SMART‐Mikroreaktoren sowie durch konventionelle Chemie in…”
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Variation der Ringgröße von Epothilonen - Totalsynthese von [14]-, [15]-, [17]- und [18]Epothilon A by Nicolaou, K. C., Sarabia, Francisco, Ninkovic, Sacha, Finlay, M. Ray V., Boddy, Christopher N. C.

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Synthesis and biological properties of C12,13-cyclopropylepothilone A and related epothilones by Nicolaou, K.C., Finlay, M.Ray V., Ninkovic, Sacha, King, N.Paul, He, Yun, Li, Tianhu, Sarabia, Francisco, Vourloumis, Dionisios

“…Background: The epothilones are natural substances that are potently cytotoxic, having an almost identical mode of action to Taxol TM as tubulin-polymerization…”
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Gezielt entworfene Epothilone: kombinatorische Synthese, Induktion der Tubulin-Polymerisation und cytotoxische Wirkung gegen taxolresistente Tumorzellen by Nicolaou, Kyriacos Costa, Vourloumis, Dionisios, Li, Tianhu, Pastor, Joaquin, Winssinger, Nicolas, He, Yun, Ninkovic, Sacha, Sarabia, Francisco, Vallberg, Hans, Roschanger, Frank, King, N. Paul, Finlay, M. Ray V., Giannakakou, Pareskevi, Verdier-Pinard, Pascal, Hamel, Ernest

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