Search Results - "Finkelman, Fred"

Human IgE-independent systemic anaphylaxis by Finkelman, Fred D., MD, Khodoun, Marat V., PhD, Strait, Richard, MD

“…Anaphylaxis is a rapidly developing, life-threatening, generalized or systemic allergic reaction that is classically elicited by antigen crosslinking of…”
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Anaphylaxis: Lessons from mouse models by Finkelman, Fred D., MD

“…Studies with mouse models demonstrate 2 pathways of systemic anaphylaxis: a classic pathway mediated by IgE, FcεRI, mast cells, histamine, and…”
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IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells by Galand, Claire, PhD, Leyva-Castillo, Juan Manuel, PhD, Yoon, Juhan, PhD, Han, Alex, BA, Lee, Margaret S., MD, PhD, McKenzie, Andrew N.J., PhD, Stassen, Michael, PhD, Oyoshi, Michiko K., PhD, Finkelman, Fred D., MD, Geha, Raif S., MD

“…Background Cutaneous exposure to food allergens predisposes to food allergy, which is commonly associated with atopic dermatitis (AD). Levels of the epithelial…”
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Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy by Chen, Chun-Yu, Lee, Jee-Boong, Liu, Bo, Ohta, Shoichiro, Wang, Pin-Yi, Kartashov, Andrey V., Mugge, Luke, Abonia, J. Pablo, Barski, Artem, Izuhara, Kenji, Rothenberg, Marc E., Finkelman, Fred D., Hogan, Simon P., Wang, Yui-Hsi

“…Experimental IgE-mediated food allergy depends on intestinal anaphylaxis driven by interleukin-9 (IL-9). However, the primary cellular source of IL-9 and the…”
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Untangling the complex web of IL-4- and IL-13-mediated signaling pathways by Wills-Karp, Marsha, Finkelman, Fred D

“…Unraveling the exact signaling events mediating the distinct functions of the T cell-derived cytokines interleukin-4 (IL-4) and IL-13 has been challenging…”
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Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion by Leyva-Castillo, Juan-Manuel, Galand, Claire, Kam, Christy, Burton, Oliver, Gurish, Michael, Musser, Melissa A., Goldsmith, Jeffrey D., Hait, Elizabeth, Nurko, Samuel, Brombacher, Frank, Dong, Chen, Finkelman, Fred D., Lee, Richard T., Ziegler, Steven, Chiu, Isaac, Austen, K. Frank, Geha, Raif S.

“…Mast cell (MC) mediator release after crosslinking of surface-bound IgE antibody by ingested antigen underlies food allergy. However, IgE antibodies are not…”
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BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses by Dey, Anup, Yang, Wenjing, Gegonne, Anne, Nishiyama, Akira, Pan, Richard, Yagi, Ryoji, Grinberg, Alex, Finkelman, Fred D, Pfeifer, Karl, Zhu, Jinfang, Singer, Dinah, Zhu, Jun, Ozato, Keiko

“…BRD4 is a BET family protein that binds acetylated histones and regulates transcription. BET/BRD4 inhibitors block blood cancer growth and inflammation and…”
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Molecular Regulation of Histamine Synthesis by Huang, Hua, Li, Yapeng, Liang, Jinyi, Finkelman, Fred D

“…Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine…”
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Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL-25, and IL-33 by Khodoun, Marat V., Tomar, Sunil, Tocker, Joel E., Wang, Yui Hsi, Finkelman, Fred D.

“…Food allergy (FA) is an increasing problem that has no approved treatment. The pro-TH2 cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are…”
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Identification of IgE as the Allergy-Associated Ig Isotype by Finkelman, Fred D

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IL-25 and CD4+ TH2 cells enhance type 2 innate lymphoid cell–derived IL-13 production, which promotes IgE-mediated experimental food allergy by Lee, Jee-Boong, Chen, Chun-Yu, Liu, Bo, Mugge, Luke, Angkasekwinai, Pornpimon, Facchinetti, Valeria, Dong, Chen, Liu, Yong-Jun, Rothenberg, Marc E., Hogan, Simon P., Finkelman, Fred D., Wang, Yui-Hsi

“…Food-mediated allergic reactions have emerged as a major health problem. The underlying mechanisms that promote uncontrolled type 2 immune responses to dietary…”
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Peanut allergy and anaphylaxis by Finkelman, Fred D

“…Peanuts are a frequent cause of food allergy and the most common cause of fatal food-induced anaphylaxis in the U.S. Advances during the past two years have…”
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The importance of mast cell histamine secretion in IgG-mediated systemic anaphylaxis by Khodoun, Marat V., Strait, Richard T., Hall, Ashley, Stolfi, Adrienne, Finkelman, Fred D.

“…[Display omitted] IgG can mediate murine and human systemic anaphylaxis (SA). The roles of mast cells (MCs) and histamine in IgG-mediated anaphylaxis are…”
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Ezh2-mediated epigenetic modification is required for allogeneic T cell-induced lupus disease by Zhen, Yuxuan, Smith, Roger D, Finkelman, Fred D, Shao, Wen-Hai

“…The mechanisms involved in the pathogenesis of autoimmune disorders, including systemic lupus erythematosus (SLE), have not been fully elucidated. Some of…”
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The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis by Li, Yapeng, Gao, Junfeng, Zhao, Dianzheng, Guan, Xiaoyu, Morris, Suzanne C., Finkelman, Fred D., Huang, Hua

“…[Display omitted] Histamine is a critical mediator of anaphylaxis, a neurotransmitter, and a regulator of gastric acid secretion. Histidine decarboxylase is a…”
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Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma by Finkelman, Fred D, Hogan, Simon P, Hershey, Gurjit K. Khurana, Rothenberg, Marc E, Wills-Karp, Marsha

“…Asthma is a common, disabling inflammatory respiratory disease that has increased in frequency and severity in developed nations. We review studies of murine…”
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Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity by Eshleman, Emily M, Rice, Taylor, Potter, Crystal, Waddell, Amanda, Hashimoto-Hill, Seika, Woo, Vivienne, Field, Sydney, Engleman, Laura, Lim, Hee-Woong, Schumacher, Michael A, Frey, Mark R, Denson, Lee A, Finkelman, Fred D, Alenghat, Theresa

“…Tuft cells in mucosal tissues are key regulators of type 2 immunity. Here, we examined the impact of the microbiota on tuft cell biology in the intestine…”
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The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell–mediated anaphylaxis by Li, Yapeng, Liu, Bing, Harmacek, Laura, Long, Zijie, Liang, Jinyi, Lukin, Kara, Leach, Sonia M., O'Connor, Brian, Gerber, Anthony N., Hagman, James, Roers, Axel, Finkelman, Fred D., Huang, Hua

“…Histamine is a critical mediator of IgE/mast cell–mediated anaphylaxis. Histamine is synthesized by decarboxylating the amino acid histidine, a reaction…”
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IL-4Rα expression by airway epithelium and smooth muscle accounts for nearly all airway hyperresponsiveness in murine allergic airway disease by McKnight, Christopher G., Potter, Crystal, Finkelman, Fred D.

“…Airway hyperresponsiveness (AHR) often defines asthma. Murine allergic airway disease (AAD), like human eosinophilic asthma, is characterized by AHR,…”
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Advances and highlights in mechanisms of allergic disease in 2015 by Wawrzyniak, Paulina, MSc, Akdis, Cezmi A., MD, Finkelman, Fred D., MD, Rothenberg, Marc E., MD, PhD

“…This review highlights some of the advances in mechanisms of allergic disease, particularly anaphylaxis, including food allergy, drug hypersensitivity, atopic…”
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