Comparison of non-invasive MRI measurements of cerebral blood flow in a large multisite cohort

Arterial spin labeling and phase contrast magnetic resonance imaging provide independent non-invasive methods for measuring cerebral blood flow. We compared global cerebral blood flow measurements obtained using pseudo-continuous arterial spin labeling and phase contrast in 436 middle-aged subjects...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism Vol. 36; no. 7; pp. 1244 - 1256
Main Authors:	Dolui, Sudipto, Wang, Ze, Wang, Danny JJ, Mattay, Raghav, Finkel, Mack, Elliott, Mark, Desiderio, Lisa, Inglis, Ben, Mueller, Bryon, Stafford, Randall B, Launer, Lenore J, Jacobs, David R, Bryan, R Nick, Detre, John A
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-07-2016
Subjects:	Adult Blood Flow Velocity - physiology Brain Mapping - methods Cerebral Arteries - diagnostic imaging Cerebral Arteries - physiology Cerebrovascular Circulation - physiology Cohort Studies Contrast Media - administration & dosage Female Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Angiography - methods Male Middle Aged Original labeling efficiency semi-automated vessel segmentation pseudo-continuous arterial spin labeling phase contrast magnetic resonance imaging Cerebral blood flow
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Arterial spin labeling and phase contrast magnetic resonance imaging provide independent non-invasive methods for measuring cerebral blood flow. We compared global cerebral blood flow measurements obtained using pseudo-continuous arterial spin labeling and phase contrast in 436 middle-aged subjects acquired at two sites in the NHLBI CARDIA multisite study. Cerebral blood flow measured by phase contrast (CBFPC: 55.76 ± 12.05 ml/100 g/min) was systematically higher (p < 0.001) and more variable than cerebral blood flow measured by pseudo-continuous arterial spin labeling (CBFPCASL: 47.70 ± 9.75). The correlation between global cerebral blood flow values obtained from the two modalities was 0.59 (p < 0.001), explaining less than half of the observed variance in cerebral blood flow estimates. Well-established correlations of global cerebral blood flow with age and sex were similarly observed in both CBFPCASL and CBFPC. CBFPC also demonstrated statistically significant site differences, whereas no such differences were observed in CBFPCASL. No consistent velocity-dependent effects on pseudo-continuous arterial spin labeling were observed, suggesting that pseudo-continuous labeling efficiency does not vary substantially across typical adult carotid and vertebral velocities, as has previously been suggested. Conclusions: Although CBFPCASL and CBFPC values show substantial similarity across the entire cohort, these data do not support calibration of CBFPCASL using CBFPC in individual subjects. The wide-ranging cerebral blood flow values obtained by both methods suggest that cerebral blood flow values are highly variable in the general population.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0271-678X 1559-7016
DOI:	10.1177/0271678X16646124