Search Results - "Fink, Sarah"

Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease by Yang, Jian-Ping, Toughiri, Rachel, Gounder, Anshu P, Scheibe, Dan, Petrus, Matt, Fink, Sarah J, Vallee, Sebastien, Kenniston, Jon, Papaioannou, Nikolaos, Langston, Steve, Gavva, Narender R, Horman, Shane R

“…Induction of fetal hemoglobin (HbF) has been shown to be a viable therapeutic approach to treating sickle cell disease and potentially other…”
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Synthetic Approaches to the New Drugs Approved During 2015 by Flick, Andrew C, Ding, Hong X, Leverett, Carolyn A, Kyne, Robert E, Liu, Kevin K. -C, Fink, Sarah J, O’Donnell, Christopher J

“…New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide…”
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Synthetic Approaches to New Drugs Approved During 2016 by Flick, Andrew C., Ding, Hong X., Leverett, Carolyn A., Fink, Sarah J., O’Donnell, Christopher J.

“…New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities provide insight…”
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Synthetic Approaches to New Drugs Approved during 2018 by Flick, Andrew C, Leverett, Carolyn A, Ding, Hong X, McInturff, Emma, Fink, Sarah J, Helal, Christopher J, DeForest, Jacob C, Morse, Peter D, Mahapatra, Subham, O’Donnell, Christopher J

“…New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide…”
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Synthetic Approaches to the New Drugs Approved During 2017 by Flick, Andrew C, Leverett, Carolyn A, Ding, Hong X, McInturff, Emma, Fink, Sarah J, Helal, Christopher J, O’Donnell, Christopher J

“…New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide…”
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A cell-penetrating PHLPP peptide improves cardiac arrest survival in murine and swine models by Li, Jing, Zhu, Xiangdong, Oberdier, Matt T, Lee, Chunpei, Lin, Shaoxia, Fink, Sarah J, Justice, Cody N, Qin, Kevin, Begeman, Andrew W, Damen, Frederick C, Kim, Hajwa, Chen, Jiwang, Cai, Kejia, Halperin, Henry R, Vanden Hoek, Terry L

“…Out-of-hospital cardiac arrest is a leading cause of death in the US, with a mortality rate over 90%. Preclinical studies demonstrate that cooling during…”
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Non‐contrast‐enhanced T1‐weighted MRI of myocardial radiofrequency ablation lesions by Guttman, Michael A., Tao, Susumu, Fink, Sarah, Kolandaivelu, Aravindan, Halperin, Henry R., Herzka, Daniel A.

“…Purpose To demonstrate imaging of radiofrequency ablation lesions with non‐contrast‐enhanced T1‐weighted (T1w) MRI. Methods Fifteen swine underwent left…”
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Synthetic Approaches to the New Drugs Approved During 2022 by France, Scott P., Lindsey, Erick A., McInturff, Emma L., Berritt, Simon, Carney, Daniel W., DeForest, Jacob C., Fink, Sarah J., Flick, Andrew C., Gibson, Tony S., Gray, Kaitlyn, Johnson, Amber M., Leverett, Carolyn A., Liu, Yiyang, Mahapatra, Subham, Watson, Rebecca B.

“…In 2022, 23 new small molecule chemical entities were approved as drugs by the United States FDA, European Union EMA, Japan PMDA, and China NMPA. This review…”
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Synthetic Approaches to the New Drugs Approved During 2020 by Flick, Andrew C., Leverett, Carolyn A., Ding, Hong X., McInturff, Emma L., Fink, Sarah J., Mahapatra, Subham, Carney, Daniel W., Lindsey, Erick A., DeForest, Jacob C., France, Scott P., Berritt, Simon, Bigi-Botterill, Simone V., Gibson, Tony S., Watson, Rebecca B., Liu, Yiyang, O’Donnell, Christopher J.

“…New drugs introduced to the market are privileged structures that have affinities for biological targets implicated in human diseases and conditions. These new…”
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Synthetic Approaches to the New Drugs Approved during 2019 by Flick, Andrew C, Leverett, Carolyn A, Ding, Hong X, McInturff, Emma, Fink, Sarah J, Mahapatra, Subham, Carney, Daniel W, Lindsey, Erick A, DeForest, Jacob C, France, Scott P, Berritt, Simon, Bigi-Botterill, Simone V, Gibson, Tony S, Liu, Yiyang, O’Donnell, Christopher J

“…New drugs introduced to the market are privileged structures having affinities for biological targets implicated in human diseases and conditions. These new…”
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Synthetic approaches to the 2014 new drugs by Flick, Andrew C., Ding, Hong X., Leverett, Carolyn A., Kyne, Robert E., Liu, Kevin K.-C., Fink, Sarah J., O’Donnell, Christopher J.

“…[Display omitted] New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities…”
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Synthetic Approaches to the New Drugs Approved During 2021 by McInturff, Emma L., France, Scott P., Leverett, Carolyn A., Flick, Andrew C., Lindsey, Erick A., Berritt, Simon, Carney, Daniel W., DeForest, Jacob C., Ding, Hong X., Fink, Sarah J., Gibson, Tony S., Gray, Kaitlyn, Hubbell, Aran K., Johnson, Amber M., Liu, Yiyang, Mahapatra, Subham, McAlpine, Indrawan J., Watson, Rebecca B., O’Donnell, Christopher J.

“…Each year, new drugs are introduced to the market, representing structures that have affinity for biological targets implicated in human diseases and…”
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Synthetic approaches to the 2013 new drugs by Ding, Hong X., Leverett, Carolyn A., Kyne, Robert E., Liu, Kevin K.-C., Fink, Sarah J., Flick, Andrew C., O’Donnell, Christopher J.

“…[Display omitted] New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities…”
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A novel social attribution paradigm: The Dynamic Interacting Shape Clips (DISC) by Ludwig, Natasha N., Hecht, Erin E., King, Tricia Z., Revill, Kate Pirog, Moore, Makeda, Fink, Sarah E., Robins, Diana L.

“…•The Dynamic Interacting Shape Clips (DISC) measure social attribution.•Behavioral and fMRI results support validation of the DISC.•Participants made expected…”
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Pulseless Electrical Activity as the Initial Cardiac Arrest Rhythm: Importance of Preexisting Left Ventricular Function by Ambinder, Daniel I., Patil, Kaustubha D., Kadioglu, Hikmet, Wetstein, Pace S., Tunin, Richard S., Fink, Sarah J., Tao, Susumu, Agnetti, Giulio, Halperin, Henry R.

“…Background Pulseless electrical activity (PEA) is a common initial rhythm in cardiac arrest. A substantial number of PEA arrests are caused by coronary…”
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Skin Failure Among Critically Ill Patients Afflicted with Coronavirus Disease 2019 (COVID-19) by Greenway, Andrew, Leahy, Nicole, Torrieri, Lisa, An, Anjile, Fink, Sarah A., Witenko, Corey, Shikar, Morgan, Winchell, Robert J., Barie, Philip S., Liu, Susan I.

“…Objective: To characterize skin integrity among coronavirus disease 2019 (COVID-19) patients treated in the intensive care unit (ICU), and identify risk…”
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Survival and Neurologic Outcomes From Pharmacologic Peptide Administration During Cardiopulmonary Resuscitation of Pulseless Electrical Activity by Oberdier, Matt T, Li, Jing, Ambinder, Daniel I, Suzuki, Masahito, Tumarkin, Ethan, Fink, Sarah, Neri, Luca, Zhu, Xiangdong, Justice, Cody N, Vanden Hoek, Terry L, Halperin, Henry R

“…Outcomes from cardiopulmonary resuscitation (CPR) following sudden cardiac arrest are suboptimal. Postresuscitation targeted temperature management has been…”
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Efficacy of antifungal agents against fungal spores: An in vitro study using microplate laser nephelometry and an artificially infected 3D skin model by Fink, Sarah, Burmester, Anke, Hipler, Uta‐Christina, Neumeister, Claudia, Götz, Marcus R., Wiegand, Cornelia

“…Dermal fungal infections seem to have increased over recent years. There is further a shift from anthropophilic dermatophytes to a growing prevalence of…”
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Cold Atmospheric Plasma Exerts Antimicrobial Effects in a 3D Skin Model of Cutaneous Candidiasis by Fink, Sarah, Fischer, Michael, Spange, Sebastian, Beier, Oliver, Horn, Kerstin, Tittelbach, Jörg, Wiegand, Cornelia

“…Cutaneous candidiasis is characterized by an overgrowth of leading to skin inflammation and infection. Similar to bacteria, can develop tolerance to common…”
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Total Synthesis of Aplyronine C by Paterson, Ian, Fink, Sarah J, Lee, Lydia Y. W, Atkinson, Stephen J, Blakey, Simon B

“…A highly stereocontrolled total synthesis of the cytotoxic marine macrolide aplyronine C is described. The route exploits aldol methodology to install the…”
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