Search Results - "Fink, Michael J."

The Molecular Origin of Enthalpy Entropy Compensation in Biomolecular Recognition by Fox, Jerome M, Zhao, Mengxia, Fink, Michael J, Kang, Kyungtae, Whitesides, George M

“…Biomolecular recognition can be stubborn; changes in the structures of associating molecules, or the environments in which they associate, often yield…”
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Analysis of Powders Containing Illicit Drugs Using Magnetic Levitation by Abrahamsson, Christoffer K., Nagarkar, Amit, Fink, Michael J., Preston, Daniel J., Ge, Shencheng, Bozenko, Joseph S., Whitesides, George M.

“…Magneto‐Archimedes levitation (MagLev) enables the separation of powdered mixtures of illicit drugs (cocaine, methamphetamine, heroin, fentanyl, and its…”
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Storage of Information Using Small Organic Molecules by Cafferty, Brian J, Ten, Alexei S, Fink, Michael J, Morey, Scott, Preston, Daniel J, Mrksich, Milan, Whitesides, George M

“…Although information is ubiquitous, and its technology arguably among the highest that humankind has produced, its very ubiquity has posed new types of…”
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Storing and Reading Information in Mixtures of Fluorescent Molecules by Nagarkar, Amit A, Root, Samuel E, Fink, Michael J, Ten, Alexei S, Cafferty, Brian J, Richardson, Douglas S, Mrksich, Milan, Whitesides, George M

“…The rapidly increasing use of digital technologies requires the rethinking of methods to store data. This work shows that digital data can be stored in…”
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Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence by Fink, Michael J., Schön, Michael, Rudroff, Florian, Schnürch, Michael, Mihovilovic, Marko D.

“…Smart catalysis cuts it short: Natural (S,S)‐Aerangis lactone and its epimer are synthesized with excellent optical purity by using in‐line hyphenation of…”
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Escherichia coli Fails to Efficiently Maintain the Activity of an Important Flavin Monooxygenase in Recombinant Overexpression by Milker, Sofia, Goncalves, Leticia C P, Fink, Michael J, Rudroff, Florian

“…This paper describes the measurement and analysis of activity and stability of cyclohexanone monooxygenase from sp. NCIMB 9871 (CHMO), a model Baeyer-Villiger…”
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Extensive substrate profiling of cyclopentadecanone monooxygenase as Baeyer–Villiger biocatalyst reveals novel regiodivergent oxidations by Fink, Michael J., Fischer, Thomas C., Rudroff, Florian, Dudek, Hanna, Fraaije, Marco W., Mihovilovic, Marko D.

“…[Display omitted] ► Extensive substrate profile of cyclopentadecanone monooxygenase. ► Comparison of enzyme performance to other BVMOs in light of phylogenetic…”
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Cloning and characterization of the Type I Baeyer–Villiger monooxygenase from Leptospira biflexa by Ceccoli, Romina D., Bianchi, Dario A., Fink, Michael J., Mihovilovic, Marko D., Rial, Daniela V.

“…Baeyer–Villiger monooxygenases are recognized by their ability and high selectivity as oxidative biocatalysts for the generation of esters or lactones using…”
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Enlightening the Path to Protein Engineering: Chemoselective Turn-On Probes for High-Throughput Screening of Enzymatic Activity by Hecko, Sebastian, Schiefer, Astrid, Badenhorst, Christoffel P. S., Fink, Michael J., Mihovilovic, Marko D., Bornscheuer, Uwe T., Rudroff, Florian

“…Many successful stories in enzyme engineering are based on the creation of randomized diversity in large mutant libraries, containing millions to billions of…”
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Non‐hazardous biocatalytic oxidation in Nylon‐9 monomer synthesis on a 40 g scale with efficient downstream processing by Milker, Sofia, Fink, Michael J., Rudroff, Florian, Mihovilovic, Marko D.

“…ABSTRACT This paper describes the development of a biocatalytic process on the multi‐dozen gram scale for the synthesis of a precursor to Nylon‐9, a specialty…”
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Redesign of water networks for efficient biocatalysis by Fink, Michael J, Syrén, Per-Olof

“…[Display omitted] •Dynamics of water expand the amino acid alphabet.•Redesign of water networks can accelerate the evolution of new biocatalytic…”
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Mutations Increasing Cofactor Affinity, Improve Stability and Activity of a Baeyer–Villiger Monooxygenase by Mansouri, Hamid R., Gracia Carmona, Oriol, Jodlbauer, Julia, Schweiger, Lorenz, Fink, Michael J., Breslmayr, Erik, Laurent, Christophe, Feroz, Saima, P. Goncalves, Leticia C., Rial, Daniela V., Mihovilovic, Marko D., Bommarius, Andreas S., Ludwig, Roland, Oostenbrink, Chris, Rudroff, Florian

“…The typically low thermodynamic and kinetic stability of enzymes is a bottleneck for their application in industrial synthesis. Baeyer–Villiger monooxygenases,…”
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Mutagenesis‐Independent Stabilization of Class B Flavin Monooxygenases in Operation by Goncalves, Leticia C. P., Kracher, Daniel, Milker, Sofia, Fink, Michael J., Rudroff, Florian, Ludwig, Roland, Bommarius, Andreas S., Mihovilovic, Marko D.

“…This paper describes the stabilization of flavin‐dependent monooxygenases under reaction conditions, using an engineered formulation of additives (the natural…”
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8399514 Update: IPRs Involving Biotech and Pharmaceutical Patents by Fink, Michael J

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Type II Flavin-Containing Monooxygenases: A New Class of Biocatalysts that Harbors Baeyer-Villiger Monooxygenases with a Relaxed Coenzyme Specificity by Riebel, Anette, Fink, Michael J., Mihovilovic, Marko D., Fraaije, Marco W.

“…Within a newly identified set of flavin‐containing monooxygenases (FMOs) from Rhodococcus jostii RHA1, we have identified three monooxygenases (FMO‐E, FMO‐F,…”
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Kinetic Modeling of an Enzymatic Redox Cascade InVivo Reveals Bottlenecks Caused by Cofactors by Milker, Sofia, Fink, Michael J, Oberleitner, Nikolin, Ressmann, Anna K, Bornscheuer, Uwe T, Mihovilovic, Marko D, Rudroff, Florian

“…We describe the development of a kinetic model for the simulation and optimization of an invivo redox cascade in E.coli in which a combination of an alcohol…”
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Extending the substrate scope of a Baeyer–Villiger monooxygenase by multiple-site mutagenesis by Dudek, Hanna M., Fink, Michael J., Shivange, Amol V., Dennig, Alexander, Mihovilovic, Marko D., Schwaneberg, Ulrich, Fraaije, Marco W.

“…Baeyer–Villiger monooxygenase-catalysed reactions are attractive for industrial processes. Here we report on expanding the substrate scope of phenylacetone…”
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Baeyer–Villiger monooxygenases in aroma compound synthesis by Fink, Michael J., Rudroff, Florian, Mihovilovic, Marko D.

“…Baeyer–Villiger monooxygenases (BVMOs) are presented as highly selective and efficient biocatalysts for the synthesis of aroma lactones via kinetic resolution…”
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A click-flipped enzyme substrate boosts the performance of the diagnostic screening for Hunter syndrome by Schwarz, Markus, Skrinjar, Philipp, Fink, Michael J, Kronister, Stefan, Mechtler, Thomas, Koukos, Panagiotis I, Bonvin, Alexandre M. J. J, Kasper, David C, Mikula, Hannes

“…We report on the unexpected finding that click modification of iduronyl azides results in a conformational flip of the pyranose ring, which led to the…”
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A Common Mechanism Links Activities of Butyrate in the Colon by Verma, Mohit S, Fink, Michael J, Salmon, Gabriel L, Fornelos, Nadine, Ohara, Takahiro E, Ryu, Stacy H, Vlamakis, Hera, Xavier, Ramnik J, Stappenbeck, Thaddeus S, Whitesides, George M

“…Two biological activities of butyrate in the colon (suppression of proliferation of colonic epithelial stem cells and inflammation) correlate with inhibition…”
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