Search Results - "Fink, Martin"

Differential diagnosis of blue toes in a newborn baby: might have been maternal infection with COVID-19? by Hochmayr, Christoph, Auckenthaler, Michael, Fink, Franz-Martin, Kiechl-Kohlendorfer, Ursula, Griesmaier, Elke

“…Laboratory investigations showed normal complete blood count, coagulation studies, and infection parameters—including C-reactive protein concentration (0·13…”
Get full text

Markov models for ion channels: versatility versus identifiability and speed by Fink, Martin, Noble, Denis

“…Markov models (MMs) represent a generalization of Hodgkin–Huxley models. They provide a versatile structure for modelling single channel data, gating currents,…”
Get full text

Translational precision medicine: an industry perspective by Hartl, Dominik, de Luca, Valeria, Kostikova, Anna, Laramie, Jason, Kennedy, Scott, Ferrero, Enrico, Siegel, Richard, Fink, Martin, Ahmed, Sohail, Millholland, John, Schuhmacher, Alexander, Hinder, Markus, Piali, Luca, Roth, Adrian

“…In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product…”
Get full text

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk by Mirams, Gary R., Cui, Yi, Sher, Anna, Fink, Martin, Cooper, Jonathan, Heath, Bronagh M., McMahon, Nick C., Gavaghan, David J., Noble, Denis

“…Aims The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers used to predict the risk of a…”
Get full text

Naval Blockade and the Humanitarian Crisis in Yemen by Fink, Martin D.

“…A Saudi Arabia-led coalition is supporting the Yemeni Government with military means against the Houthis in Yemen. Part of those military operations are naval…”
Get full text

Case report: metoclopramide induced acute dystonic reaction in adolescent CYP2D6 poor metabolizers by Fink, Franz-Martin, Bognar, Marta, Hengl, Petra, Paulmichl, Markus, Nofziger, Charity

“…Metoclopramide is indicated for the management of gastroesophageal reflux, gastric stasis, nausea, and vomiting. Metoclopramide-induced acute dystonic…”
Get full text

Impact of ionic current variability on human ventricular cellular electrophysiology by Romero, Lucía, Pueyo, Esther, Fink, Martin, Rodríguez, Blanca

“…Abnormalities in repolarization and its rate dependence are known to be related to increased proarrhythmic risk. A number of repolarization-related…”
Get more information

Exposure‐response modeling for extrapolation from adult to pediatric patients who differ with respect to prognostic factors: Application to everolimus by Dumortier, Thomas, Heimann, Günter, Fink, Martin

“…Pediatric extrapolation is essential for bringing treatments to the pediatric population, especially for indications where the recruitment of pediatric…”
Get full text

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts by Fink, Martin, Callol-Massot, Carles, Chu, Angela, Ruiz-Lozano, Pilar, Izpisua Belmonte, Juan Carlos, Giles, Wayne, Bodmer, Rolf, Ocorr, Karen

“…The genetic basis of heart development is remarkably conserved from Drosophila to mammals, and insights from flies have greatly informed our understanding of…”
Get full text

Terminal Ileitis as the Exclusive Manifestation of COVID-19 in Children by Schuler, Lea Maria, Falkensammer, Barbara, Orlik, Peter, Auckenthaler, Michael, Kranewitter, Christof, Bante, David, von Laer, Dorothee, Fink, Franz-Martin

“…The clinical presentation, organ involvement, and severity of disease caused by SARS-CoV-2 are highly variable, ranging from asymptomatic or mild infection to…”
Get full text

Rehospitalization in the first 2 years of life in children born preterm by Ralser, Elisabeth, Mueller, Wilfried, Haberland, Claudia, Fink, Franz-Martin, Gutenberger, Karl-Heinz, Strobl, Robert, Kiechl-Kohlendorfer, Ursula

“…Aim:  Aim of the study is to investigate the frequency of and predictors for rehospitalization within the first 2 years of life among preterm infants. Methods:…”
Get full text

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging by Ocorr, Karen, Reeves, Nick L, Wessells, Robert J, Fink, Martin, Chen, H.-S. Vincent, Akasaka, Takeshi, Yasuda, Soichiro, Metzger, Joseph M, Giles, Wayne, Posakony, James W, Bodmer, Rolf

“…Population profiles of industrialized countries show dramatic increases in cardiovascular disease with age, but the molecular and genetic basis of disease…”
Get full text

LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial by Loesche, Christian, Picard, Damien, Van Hoorick, Benjamin, Schuhmann, Imelda, Jäger, Petra, Klein, Kai, Schuhler, Carole, Thoma, Gebhard, Markert, Christian, Poller, Birk, Zamurovic, Natasa, Weiss, H. Markus, Otto, Heike, Fink, Martin, Röhn, Till A.

“…LYS006 is a novel, highly potent and selective, new‐generation leukotriene A4 hydrolase (LTA4H) inhibitor in clinical development for the treatment of…”
Get full text

Target-directed development and preclinical characterization of the proposed biosimilar rituximab GP2013 by da Silva, Antonio, Kronthaler, Ulrich, Koppenburg, Vera, Fink, Martin, Meyer, Ines, Papandrikopoulou, Anastassia, Hofmann, Matthias, Stangler, Thomas, Visser, Jan

“…Abstract Biosimilar development involves a target-directed iterative process to ensure a similar product to the originator. Here we report the preclinical…”
Get full text

Inhibition of the Na+ /Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3 by Milberg, Peter, MD, Pott, Christian, MD, Fink, Martin, PhD, Frommeyer, Gerrit, MS, Matsuda, Toshio, PhD, Baba, Akemichi, PhD, Osada, Nani, PhD, Breithardt, Günter, MD, FESC, FACC, FHRS, Noble, Denis, PhD, CBE, FRS, FRCP (Hon), Eckardt, Lars, MD

“…Background Long QT syndrome (LQTS) is associated with sudden cardiac death resulting from torsades de pointes (TdP), which are triggered by early…”
Get full text

Construction and Significance of Corporate Social Responsibility Indices – from Results to the Essence by Bernardová, Dana, Kašparová, Klára, Fink, Martin, Ivanová, Kateřina, Arkhangelska, Tetiana

“…Regular reporting on Corporate Social Responsibility (hereinafter referred to as CSR) should make it easier for enterprises to identify the sustainability…”
Get full text

Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects by Witte, A. Veronica, Flöel, Agnes, Stein, Patrycja, Savli, Markus, Mien, Leonhard-Key, Wadsak, Wolfgang, Spindelegger, Christoph, Moser, Ulrike, Fink, Martin, Hahn, Andreas, Mitterhauser, Markus, Kletter, Kurt, Kasper, Siegfried, Lanzenberger, Rupert

“…Objectives: Various studies indicate that serotonin regulates impulsivity and the inhibitory control of aggression. Aggression is also known to be modified by…”
Get full text

Population pharmacokinetic analysis for 10-monohydroxy derivative of oxcarbazepine in pediatric epileptic patients shows no difference between Japanese and other ethnicities by Sugiyama, Ikuo, Bouillon, Thomas, Yamaguchi, Masayuki, Suzuki, Hikoe, Hirota, Takashi, Fink, Martin

“…Oxcarbazepine is an anti-epileptic drug, which is almost completely metabolized by cytosolic enzymes in the liver to the active 10-monohyroxy metabolite (MHD)…”
Get full text

Acute inhibition of the Na+ /Ca2+ exchanger reduces proarrhythmia in an experimental model of chronic heart failure by Milberg, Peter, MD, Pott, Christian, MD, Frommeyer, Gerrit, MD, Fink, Martin, PhD, Ruhe, Matthias, MS, Matsuda, Toshio, PhD, Baba, Akemichi, PhD, Klocke, Rainer, PhD, Quang, Trong Hung, PhD, Nikol, Sigrid, MD, Stypmann, Jörg, MD, Osada, Nani, PhD, Müller, Frank U., MD, Breithardt, Günter, MD, FESC, FACC, FHRS, Noble, Dennis, PhD, CBE, FRS, FRCP (Hon), Eckardt, Lars, MD

“…Background Molecular remodeling in heart failure includes slowing of repolarization, leading to proarrhythmia. Objective To evaluate the effects of Na+ /Ca2+…”
Get full text

Long‐term outcome of initially homogenously treated and relapsed childhood acute lymphoblastic leukaemia in Austria – A population‐based report of the Austrian Berlin‐Frankfurt‐Münster (BFM) Study Group by Reismüller, Bettina, Attarbaschi, Andishe, Peters, Christina, Dworzak, Michael N., Pötschger, Ulrike, Urban, Christian, Fink, Franz‐Martin, Meister, Bernhard, Schmitt, Klaus, Dieckmann, Karin, Henze, Günter, Haas, Oskar A., Gadner, Helmut, Mann, Georg

“…Summary Relapsed acute lymphoblastic leukaemia (ALL) is the most common cause for a fatal outcome in paediatric oncology. Although initial ALL cure rates have…”
Get full text