Search Results - "Fink, Gregor"
-
1
Elevated n-3/n-6 PUFA ratio in early life diet reverses adverse intrauterine kidney programming in female rats
Published in Journal of lipid research (01-11-2022)“…Intrauterine growth restriction (IUGR) predisposes to chronic kidney disease via activation of proinflammatory pathways, and omega-3 PUFAs (n-3 PUFAs) have…”
Get full text
Journal Article -
2
Mycophenolic acid directly protects podocytes by preserving the actin cytoskeleton and increasing cell survival
Published in Scientific reports (15-03-2023)“…Mycophenolate Mofetil (MMF) has an established role as a therapeutic agent in childhood nephrotic syndrome. While other immunosuppressants have been shown to…”
Get full text
Journal Article -
3
The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
Published in Nutrition & metabolism (27-11-2021)“…Abstract Being born small-for-gestational-age, especially with subsequent catch-up growth, is associated with impaired metabolic health in later-life. We…”
Get full text
Journal Article -
4
Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction
Published in Nutrients (20-01-2022)“…Fetal growth restriction (FGR) has been linked to long-term neurocognitive impairment, especially in males. To determine possible underlying mechanisms, we…”
Get full text
Journal Article -
5
Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
Published in ERJ open research (01-07-2021)“…RESEARCH QUESTIONPulmonary disease progression in patients with cystic fibrosis (CF) is characterised by inflammation and fibrosis and aggravated by…”
Get full text
Journal Article -
6
Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers
Published in Cells (Basel, Switzerland) (19-05-2021)“…Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for both mother and offspring and targeted interventions to address this…”
Get full text
Journal Article -
7
Impact of early-life diet on long-term renal health
Published in Molecular and cellular pediatrics (03-12-2020)“…In the last years, great advances have been made in the effort to understand how nutritional influences can affect long-term renal health. Evidence has…”
Get full text
Journal Article -
8
Characterization of the Direct Effect of Mycophenolic Acid on Murine Podocytes: PO1659
Published in Journal of the American Society of Nephrology (01-10-2021)Get full text
Journal Article -
9
IL‐6/Smad2 signaling mediates acute kidney injury and regeneration in a murine model of neonatal hyperoxia
Published in The FASEB journal (01-05-2019)“…ABSTRACTPrematurity is linked to incomplete nephrogenesis and risk of chronic kidney diseases (CKDs). Oxygen is life‐saving in that context but induces injury…”
Get full text
Journal Article -
10
Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming
Published in Scientific reports (22-09-2020)“…Maternal exercise (ME) during pregnancy has been shown to improve metabolic health in offspring and confers protection against the development of non-alcoholic…”
Get full text
Journal Article -
11
Altered molecular signatures during kidney development after intrauterine growth restriction of different origins
Published in Journal of molecular medicine (Berlin, Germany) (01-03-2020)“…This study was performed to identify transcriptional alterations in male intrauterine growth restricted (IUGR) rats during and at the end of nephrogenesis in…”
Get full text
Journal Article -
12
Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β 1 are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
Published in ERJ open research (01-07-2021)“…Research question Pulmonary disease progression in patients with cystic fibrosis (CF) is characterised by inflammation and fibrosis and aggravated by…”
Get full text
Journal Article -
13
Maternal High Fat Diet and in-Utero Metformin Exposure Significantly Impact upon the Fetal Renal Proteome of Male Mice
Published in Journal of clinical medicine (11-05-2019)“…There is accumulating evidence for fetal programming of later kidney disease by maternal obesity or associated conditions. We performed a hypothesis-generating…”
Get full text
Journal Article