Search Results - "Fink, Brian"

Keeping Children, Teachers, and Staff in School: How to Prepare Schools for the Next Pandemic by Fink, Brian N.

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How Communities Can Help Their Schools from Becoming the Next Active Shooting Site: The Menu Approach by Fink, Brian N.

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Regulation of ATP production: dependence on calcium concentration and respiratory state by Fink, Brian D, Bai, Fan, Yu, Liping, Sivitz, William I

“…Nanomolar free calcium enhances oxidative phosphorylation. However, the effects over a broad concentration range, at different respiratory states, or on…”
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Effect of the mitochondrial transaminase (GOT2) on membrane potential-sensitive respiration in mitochondria of differentiated C2C12 muscle cells by Som, Ritu, Fink, Brian D, Yu, Liping, Sivitz, William I

“…We previously showed that the transaminase inhibitor, aminooxyacetic acid, reduced respiration energized at complex II (succinate dehydrogenase, SDH) in…”
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Experiences of sexual violence and their associations with suicidal ideation and behavior in the past year: an analysis of adults from the 2021 Ace Community Survey by Fink, Brian N

“…This research assessed forms of sexual violence and their associations with suicidal ideation among adults identifying on the asexual identity spectrum. A…”
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Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression by Som, Ritu, Fink, Brian D, Yu, Liping, Sivitz, William I

“…We previously found that skeletal muscle mitochondria incubated at low membrane potential (ΔΨ) or interscapular brown adipose tissue (IBAT) mitochondria,…”
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A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation by Kulkarni, Chaitanya A, Fink, Brian D, Gibbs, Bettine E, Chheda, Pratik R, Wu, Meng, Sivitz, William I, Kerns, Robert J

“…Mitochondrial dysfunction is an underlying pathology in numerous diseases. Delivery of diagnostic and therapeutic cargo directly into mitochondria is a…”
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Modulation of complex II‐energized respiration in muscle, heart, and brown adipose mitochondria by oxaloacetate and complex I electron flow by Fink, Brian D., Yu, Liping, Sivitz, William I.

“…We recently reported that membrane potential (Δψ) primarily determines the relationship of complex II‐supported respiration by isolated skeletal muscle…”
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Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: Divergent control in skeletal muscle and brown adipose tissue by Yu, Liping, Fink, Brian D, Som, Ritu, Rauckhorst, Adam J, Taylor, Eric B, Sivitz, William I

“…At low inner mitochondrial membrane potential (ΔΨ) oxaloacetate (OAA) accumulates in the organelles concurrently with decreased complex II-energized…”
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CaMKII determines mitochondrial stress responses in heart by Joiner, Mei-ling A., Koval, Olha M., Li, Jingdong, He, B. Julie, Allamargot, Chantal, Gao, Zhan, Luczak, Elizabeth D., Hall, Duane D., Fink, Brian D., Chen, Biyi, Yang, Jinying, Moore, Steven A., Scholz, Thomas D., Strack, Stefan, Mohler, Peter J., Sivitz, William I., Song, Long-Sheng, Anderson, Mark E.

“…Calcium exchange and cardiac stress Increased mitochondrial calcium entry has been implicated in myocardial death, heart failure and related conditions. Here,…”
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Simultaneous Quantification of Mitochondrial ATP and ROS Production Using ATP Energy Clamp Methodology by Yu, Liping, Fink, Brian D, Sivitz, William I

“…Several methods are available to measure ATP production by isolated mitochondria or permeabilized cells but have several limitations, depending upon the…”
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Voltage-Dependent Regulation of Complex II Energized Mitochondrial Oxygen Flux by Bai, Fan, Fink, Brian D, Yu, Liping, Sivitz, William I

“…Oxygen consumption by isolated mitochondria is generally measured during state 4 respiration (no ATP production) or state 3 (maximal ATP production at high ADP…”
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Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II–driven respiration by Fink, Brian D., Bai, Fan, Yu, Liping, Sheldon, Ryan D., Sharma, Arpit, Taylor, Eric B., Sivitz, William I.

“…We recently reported a previously unrecognized mitochondrial respiratory phenomenon. When [ADP] was held constant (“clamped”) at sequentially increasing…”
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Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition by Fink, Brian D, Herlein, Judy A, O'Malley, Yunxia, Sivitz, William I

“…It has been suggested that cells that are independent of insulin for glucose uptake, when exposed to high glucose or other nutrient concentrations, manifest…”
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Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells by Liu, Siming, Promes, Joseph A, Harata, Mikako, Mishra, Akansha, Stephens, Samuel B, Taylor, Eric B, Burand, Jr, Anthony J, Sivitz, William I, Fink, Brian D, Ankrum, James A, Imai, Yumi

“…Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse β-cells, LDs are prominent…”
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Impaired utilization of membrane potential by complex II-energized mitochondria of obese, diabetic mice assessed using ADP recycling methodology by Fink, Brian D, Bai, Fan, Yu, Liping, Sivitz, William I

“…Recently, we used an ADP recycling approach to examine mouse skeletal muscle (SkM) mitochondrial function over respiratory states intermittent between state 3…”
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Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells by Fink, Brian D, Herlein, Judith A, Yorek, Mark A, Fenner, Amanda M, Kerns, Robert J, Sivitz, William I

“…Mitochondrial-targeted analogs of coenzyme Q (CoQ) are under development to reduce oxidative damage induced by a variety of disease states. However, there is a…”
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Reactive Oxygen and Targeted Antioxidant Administration in Endothelial Cell Mitochondria by O'Malley, Yunxia, Fink, Brian D., Ross, Nicolette C., Prisinzano, Thomas E., Sivitz, William I.

“…We used fluorescent probes and EPR to study the mechanism(s) underlying reactive oxygen species (ROS) production by endothelial cell mitochondria and the…”
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Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI) by Harikrishnan, Lalgudi S., Warrier, Jayakumar, Tebben, Andrew J., Tonukunuru, Gopikishan, Madduri, Sudhakara R., Baligar, Vishweshwaraiah, Mannoori, Raju, Seshadri, Balaji, Rahaman, Hasibur, Arunachalam, P.N., Dikundwar, Amol G., Fink, Brian E., Fargnoli, Joseph, Fereshteh, Mark, Fan, Yi, Lippy, Jonathan, Ho, Ching-Ping, Wautlet, Barri, Sheriff, Steven, Ruzanov, Max, Borzilleri, Robert M.

“…[Display omitted] The TGFβ-TGFβR signaling pathway has been reported to play a protective role in the later stages of tumorigenesis via increasing…”
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Dietary fat, fatty acid saturation and mitochondrial bioenergetics by Yu, Liping, Fink, Brian D., Herlein, Judith A., Oltman, Christine L., Lamping, Kathryn G., Sivitz, William I.

“…Fat intake alters mitochondrial lipid composition which can affect function. We used novel methodology to assess bioenergetics, including simultaneous ATP and…”
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