Search Results - "Finger, L. David"

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily by Tsutakawa, Susan E., Classen, Scott, Chapados, Brian R., Arvai, Andrew S., Finger, L. David, Guenther, Grant, Tomlinson, Christopher G., Thompson, Peter, Sarker, Altaf H., Shen, Binghui, Cooper, Priscilla K., Grasby, Jane A., Tainer, John A.

“…Flap endonuclease (FEN1), essential for DNA replication and repair, removes RNA and DNA 5′ flaps. FEN1 5′ nuclease superfamily members acting in nucleotide…”
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Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability by Tsutakawa, Susan E., Thompson, Mark J., Arvai, Andrew S., Neil, Alexander J., Shaw, Steven J., Algasaier, Sana I., Kim, Jane C., Finger, L. David, Jardine, Emma, Gotham, Victoria J.B., Sarker, Altaf H., Her, Mai Z., Rashid, Fahad, Hamdan, Samir M., Mirkin, Sergei M., Grasby, Jane A., Tainer, John A.

“…DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely…”
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Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site by Exell, Jack C, Thompson, Mark J, Finger, L David, Shaw, Steven J, Debreczeni, Judit, Ward, Thomas A, McWhirter, Claire, Siöberg, Catrine L B, Molina, Daniel Martinez, Abbott, W Mark, Jones, Clifford D, Nissink, J Willem M, Durant, Stephen T, Grasby, Jane A

“…Structural, enzymatic and cellular target engagement studies reveal the mechanism of action by N -hydroxyurea small molecule inhibitors of the DNA repair…”
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Observation of unpaired substrate DNA in the flap endonuclease-1 active site by Finger, L David, Patel, Nikesh, Beddows, Amanda, Ma, Long, Exell, Jack C, Jardine, Emma, Jones, Anita C, Grasby, Jane A

“…The structure- and strand-specific phosphodiesterase flap endonuclease-1 (FEN1), the prototypical 5'-nuclease, catalyzes the essential removal of…”
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Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1 by Bennet, Ian A, Finger, L David, Baxter, Nicola J, Ambrose, Benjamin, Hounslow, Andrea M, Thompson, Mark J, Exell, Jack C, Shahari, Nur Nazihah B Md, Craggs, Timothy D, Waltho, Jonathan P, Grasby, Jane A

“…Abstract Human flap endonuclease-1 (hFEN1) catalyzes the divalent metal ion-dependent removal of single-stranded DNA protrusions known as flaps during DNA…”
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The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis by Finger, L. David, Blanchard, M. Suzette, Theimer, Carla A., Sengerová, Blanka, Singh, Purnima, Chavez, Valerie, Liu, Fei, Grasby, Jane A., Shen, Binghui

“…Flap endonuclease 1 (FEN1) proteins, which are present in all kingdoms of life, catalyze the sequence-independent hydrolysis of the bifurcated nucleic acid…”
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Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases by Shen, Binghui, Singh, Purnima, Liu, Ren, Qiu, Junzhuan, Zheng, Li, Finger, L. David, Alas, Steve

“…Flap EndoNuclease‐1 (FEN‐1) is a multifunctional and structure‐specific nuclease involved in nucleic acid processing pathways. It plays a critical role in…”
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Mutations Linked to Dyskeratosis Congenita Cause Changes in the Structural Equilibrium in Telomerase RNA by Theimer, Carla A., Finger, L. David, Trantirek, Lukas, Feigon, Juli

“…Autosomal dominant dyskeratosis congenita (DKC), as well as aplastic anemia, has been linked to mutations in the RNA component of telomerase, the…”
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The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome by Trego, Kelly S., Chernikova, Sophia B., Davalos, Albert R., Perry, J. Jefferson P., Finger, L. David, Ng, Cliff, Tsai, Miaw-Sheue, Yannone, Steven M., Tainer, John A., Campisi, Judith, Cooper, Priscilla K.

“…XPG is a structure-specific endonuclease required for nucleotide excision repair (NER). XPG incision defects result in the cancer-prone syndrome xeroderma…”
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Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined Substrates by Moré, Margret I., Finger, L. David, Stryker, Joel L., Fuqua, Clay, Eberhard, Anatol, Winans, Stephen C.

“…Many bacteria, including several pathogens of plants and humans, use a pheromone called an autoinducer to regulate gene expression in a cell density-dependent…”
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Functional regulation of FEN1 nuclease and its link to cancer by Zheng, Li, Jia, Jia, Finger, L David, Guo, Zhigang, Zer, Cindy, Shen, Binghui

“…Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease family. FEN1 possesses FEN, 5'-exonuclease and gap-endonuclease activities. The…”
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Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links by Morton, Sally B., Finger, L. David, van der Sluijs, Roxanne, Mulcrone, William D., Hodskinson, Michael, Millington, Christopher L., Vanhinsbergh, Christina, Patel, Ketan J., Dickman, Mark J., Knipscheer, Puck, Grasby, Jane A., Williams, David M.

“…DNA interstrand cross-links (ICLs) prevent DNA replication and transcription and can lead to potentially lethal events, such as cancer or bone marrow failure…”
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Flap Endonuclease 1 Mutations A159V and E160D Cause Genomic Instability by Slowing Reaction on Double-Flap Substrates by Algasaier, Sana I, Finger, L. David, Bennet, Ian A, Grasby, Jane A

“…Flap endonuclease 1 (FEN1) is a structure-selective nuclease best known for its roles in the penultimate steps of Okazaki fragment maturation, long-patch base…”
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Human Exonuclease 1 Threads 5′-Flap Substrates through Its Helical Arch by Shaw, Steven J, Finger, L. David, Grasby, Jane A

“…Human exonuclease 1 (hEXO1) is a member of the 5′-nuclease superfamily and plays important roles in DNA repair. Along with acting as a 5′-exonuclease on blunt,…”
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Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases by Grasby, Jane A., Finger, L. David, Tsutakawa, Susan E., Atack, John M., Tainer, John A.

“…Structure-specific 5′-nucleases form a superfamily of evolutionarily conserved phosphodiesterases that catalyse a precise incision of a diverse range of DNA…”
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DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction by Algasaier, Sana I., Exell, Jack C., Bennet, Ian A., Thompson, Mark J., Gotham, Victoria J.B., Shaw, Steven J., Craggs, Timothy D., Finger, L. David, Grasby, Jane A.

“…Human flap endonuclease-1 (hFEN1) catalyzes the essential removal of single-stranded flaps arising at DNA junctions during replication and repair processes…”
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Proline Scanning Mutagenesis Reveals a Role for the Flap Endonuclease-1 Helical Cap in Substrate Unpairing by Patel, Nikesh, Exell, Jack C., Jardine, Emma, Ombler, Ben, Finger, L. David, Ciani, Barbara, Grasby, Jane A.

“…The prototypical 5′-nuclease, flap endonuclease-1 (FEN1), catalyzes the essential removal of single-stranded flaps during DNA replication and repair. FEN1…”
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Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends by Patel, Nikesh, Atack, John M, Finger, L David, Exell, Jack C, Thompson, Peter, Tsutakawa, Susan, Tainer, John A, Williams, David M, Grasby, Jane A

“…Flap endonucleases (FENs), essential for DNA replication and repair, recognize and remove RNA or DNA 5'-flaps. Related to FEN specificity for substrates with…”
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The wonders of flap endonucleases: structure, function, mechanism and regulation by Finger, L David, Atack, John M, Tsutakawa, Susan, Classen, Scott, Tainer, John, Grasby, Jane, Shen, Binghui

“…Processing of Okazaki fragments to complete lagging strand DNA synthesis requires coordination among several proteins. RNA primers and DNA synthesised by DNA…”
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Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases by Beddows, Amanda, Patel, Nikesh, Finger, L David, Atack, John M, Williams, David M, Grasby, Jane A

“…Flap endonucleases (FENs) are proposed to select their target phosphate diester by unpairing the two terminal nucleotides of duplex. Interstrand disulfide…”
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