Search Results - "Finger, Joshua N"

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4 by Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos, Gough, Peter J., Bertin, John, Whalen, Michael J., Pasparakis, Manolis, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander, Degterev, Alexei

“…Macrophages are a crucial component of the innate immune system in sensing pathogens and promoting local and systemic inflammation. RIPK1 and RIPK3 are…”
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Herpes Simplex Virus Suppresses Necroptosis in Human Cells by Guo, Hongyan, Omoto, Shinya, Harris, Philip A., Finger, Joshua N., Bertin, John, Gough, Peter J., Kaiser, William J., Mocarski, Edward S.

“…Herpes simplex virus (HSV)-1 and HSV-2 are significant human pathogens causing recurrent disease. During infection, HSV modulates cell death pathways using the…”
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Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity by Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John J., Gough, Peter J.

“…Background: NLRP1 mediates the release of the inflammatory cytokine IL-1β and is linked to several human inflammatory diseases. Results: Autolytic proteolysis…”
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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer by Harris, Philip A, Marinis, Jill M, Lich, John D, Berger, Scott B, Chirala, Anirudh, Cox, Julie A, Eidam, Patrick M, Finger, Joshua N, Gough, Peter J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Leister, Lara K, Mahajan, Mukesh K, Miller, George, Nagilla, Rakesh, Ouellette, Michael T, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Sun, Helen H, Thorpe, James H, Totoritis, Rachel D, Wang, Wei, Wu, Dongling, Zhang, Daohua, Bertin, John, Marquis, Robert W

“…RIP1 regulates cell death and inflammation and is believed to play an important role in contributing to a variety of human pathologies, including…”
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The Rat Epididymal Transcriptome: Comparison of Segmental Gene Expression in the Rat and Mouse Epididymides by JELINSKY, Scott A, TURNER, Terry T, BANG, Hyun J, FINGER, Joshua N, SOLARZ, Mark K, WILSON, Ewa, BROWN, Eugene L, KOPF, Gregory S, JOHNSTON, Daniel S

“…Regional differences along the epididymis are essential for the establishment of the luminal environment required for sperm maturation. In the current study,…”
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Differential Gene Expression among the Proximal Segments of the Rat Epididymis Is Lost after Efferent Duct Ligation by TURNER, Terry T, JOHNSTON, Daniel S, FINGER, Joshua N, JELINSKY, Scott A

“…The epididymis has traditionally been divided into the caput, corpus, and cauda regions, which are further organized into intraregional segments. In the rat…”
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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases by Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John

“…RIP1 regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated…”
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Gene Expression During Development of Fetal and Adult Leydig Cells by DONG, LEI, JELINSKY, SCOTT A., FINGER, JOSHUA N., JOHNSTON, DANIEL S., KOPF, GREGORY S., SOTTAS, CHANTAL M., HARDY, MATTHEW P., GE, REN-SHAN

“…: In rats and mice, Leydig cells are formed as two morphologically and functionally different generations. The first generation develops in utero, from…”
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors by Harris, Philip A, King, Bryan W, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Finger, Joshua N, Grady, LaShadric C, Hoffman, Sandra J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Lakdawala, Ami S, Lehr, Ruth, McNulty, Dean E, Nagilla, Rakesh, Ouellette, Michael T, Pao, Christina S, Rendina, Alan R, Schaeffer, Michelle C, Summerfield, Jennifer D, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Zhang, Aming, Zhang, Daohua, Marquis, Robert W, Bertin, John, Gough, Peter J

“…The recent discovery of the role of receptor interacting protein 1 (RIP1) kinase in tumor necrosis factor (TNF)-mediated inflammation has led to its emergence…”
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Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profiling by Johnston, Daniel S., Turner, Terry T., Finger, Joshua N., Owtscharuk, Tracy L., Kopf, Gregory S., Jelinsky, Scott A.

“…As part of our efforts to identify novel contraceptive targets in the epididymis we performed transcriptional profiling on each of the 10 and 19 segments of…”
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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase by Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N

“…RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1…”
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Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligation by Turner, Terry T., Johnston, Daniel S., Jelinsky, Scott A., Tomsig, Jose L., Finger, Joshua N.

“…The epididymis is divided into caput, corpus and cauda regions, organized into intraregional segments separated by connective tissue septa (CTS). In the adult…”
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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis by Harris, Philip A, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Finger, Joshua N, Hoffman, Sandra J, Kahler, Kirsten M, Lehr, Ruth, Lich, John D, Nagilla, Rakesh, Nolte, Robert T, Ouellette, Michael T, Pao, Christina S, Schaeffer, Michelle C, Smallwood, Angela, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Marquis, Robert W, Bertin, John, Gough, Peter J

“…Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines, and furo[2,3-d]pyrimidines, all of the type II…”
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Differential Gene Expression among the Proximal Segments of the Rat Epididymis Is Lost after Efferent Duct Ligation1 by Turner, Terry T, Johnston, Daniel S, Finger, Joshua N, Jelinsky, Scott A

“…The epididymis has traditionally been divided into the caput, corpus, and cauda regions, which are further organized into intraregional segments. In the rat…”
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Identification of Testis-Specific Male Contraceptive Targets by JOHNSTON, DANIEL S., JELINSKY, SCOTT A., ZHI, YU, FINGER, JOSHUA N., KOPF, GREGORY S., WRIGHT, WILLIAM W.

“…: In an effort to identify novel targets for the development of nonhormonal male contraceptives, genome‐wide transcriptional profiling of the rat testis was…”
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The Rat Epididymal Transcriptome: Comparison of Segmental Gene Expression in the Rat and Mouse Epididymides1 by Jelinsky, Scott A, Turner, Terry T, Bang, Hyun J, Finger, Joshua N, Solarz, Mark K, Wilson, Ewa, Brown, Eugene L, Kopf, Gregory S, Johnston, Daniel S

“…Regional differences along the epididymis are essential for the establishment of the luminal environment required for sperm maturation. In the current study,…”
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Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity by Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John, Gough, Peter J.

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Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues by Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.

“…Therapies that suppress RIPK1 kinase activity are emerging as promising therapeutic agents for the treatment of multiple inflammatory disorders. The ability to…”
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Identification of testis-specific male contraceptive targets: insights from transcriptional profiling of the cycle of the rat seminiferous epithelium and purified testicular cells by Johnston, Daniel S, Jelinsky, Scott A, Zhi, Yu, Finger, Joshua N, Kopf, Gregory S, Wright, William W

“…In an effort to identify novel targets for the development of nonhormonal male contraceptives, genome-wide transcriptional profiling of the rat testis was…”
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Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK 1 inhibitors in cells and tissues by Finger, Joshua N., Brusq, Jean‐Marie, Campobasso, Nino, Cook, Michael N., Deutsch, Jennifer, Haag, Heather, Harris, Philip A., Jenkins, Earl L., Joglekar, Devika, Lich, John D., Maguire, Sean, Nagilla, Rakesh, Rivera, Elizabeth J., Sun, Helen, Votta, Bartholomew J., Bertin, John, Gough, Peter J.

“…Abstract Therapies that suppress RIPK 1 kinase activity are emerging as promising therapeutic agents for the treatment of multiple inflammatory disorders. The…”
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