Search Results - "Fine, Jared M"

Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease by Kosyakovsky, Jacob, Fine, Jared M, Frey, 2nd, William H, Hanson, Leah R

“…Identifying disease-modifying therapies for neurological diseases remains one of the greatest gaps in modern medicine. Herein, we present the rationale for…”
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Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson’s Disease by Fine, Jared M., Stroebel, Benjamin M., Faltesek, Katherine A., Terai, Kaoru, Haase, Lucas, Knutzen, Kristin E., Kosyakovsky, Jacob, Bowe, Tate J., Fuller, Austin K., Frey, William H., Hanson, Leah R.

“…•We determined whether intranasal insulin would mitigate the behavioral and neuropathological effects of 6-OHDA in a rat model of PD.•Insulin decreased the…”
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Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation by Fine, Jared M., Renner, Daniel B., Forsberg, Anna C., Cameron, Rachel A., Galick, Benjamin T., Le, Clint, Conway, Patrick M., Stroebel, Benjamin M., Frey, William H., Hanson, Leah R.

“…•Intranasal DFO reduces working and reference memory loss in an amyloid mouse model.•Intranasal DFO modifies several targets along multiple pathways in…”
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Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey by Sorensen, Peter W, Hoye, Thomas R, Fine, Jared M, Dvornikovs, Vadims, Jeffrey, Christopher S, Shao, Feng, Wang, Jizhou, Vrieze, Lance A, Anderson, Kari R

“…The sea lamprey is an ancient, parasitic fish that invaded the Great Lakes a century ago, where it triggered the collapse of many fisheries. Like many fishes,…”
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Isolation and Biological Activity of the Multi-Component Sea Lamprey Migratory Pheromone by Fine, Jared M, Sorensen, Peter W

“…Migratory adult sea lampreys locate spawning streams by using a pheromone released by stream-resident conspecific larvae. It was recently reported that this…”
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Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement by Fine, Jared M., Kosyakovsky, Jacob, Baillargeon, Amanda M., Tokarev, Julian V., Cooner, Jacob M., Svitak, Aleta L., Faltesek, Katherine A., Frey, William H., Hanson, Leah R.

“…Introduction Intranasal deferoxamine (IN DFO) has been shown to decrease memory loss and have beneficial impacts across several models of neurologic disease…”
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Intranasal Administration of CNS Therapeutics to Awake Mice by Hanson, Leah R., Fine, Jared M., Svitak, Aleta L., Faltesek, Katherine A.

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Sterol-Like Odorant in the Urine of Mozambique Tilapia Males Likely Signals Social Dominance to Females by Barata, Eduardo N, Fine, Jared M, Hubbard, Peter C, Almeida, Olinda G, Frade, Pedro, Sorensen, Peter W, Canário, Adelino V. M

“…Many species of freshwater fish with relatively simple mating strategies release hormonally derived sex pheromones in urine. However, it is not known whether…”
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Details of the Structure Determination of the Sulfated Steroids PSDS and PADS:  New Components of the Sea Lamprey (Petromyzon marinus) Migratory Pheromone by Hoye, Thomas R, Dvornikovs, Vadims, Fine, Jared M, Anderson, Kari R, Jeffrey, Christopher S, Muddiman, David C, Shao, Feng, Sorensen, Peter W, Wang, Jizhou

“…The discovery of two new components of the migratory pheromone used by sea lamprey to guide adults to spawning grounds was recently reported. These hold…”
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Rescue therapies for seizure emergencies: New modes of administration by Maglalang, Patricia D., Rautiola, Davin, Siegel, Ronald A., Fine, Jared M., Hanson, Leah R., Coles, Lisa D., Cloyd, James C.

“…Summary A subgroup of patients with drug‐resistant epilepsy have seizure clusters, which are a part of the continuum of seizure emergencies that includes…”
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Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats by Rautiola, Davin, Maglalang, Patricia D, Cheryala, Narsihmulu, Nelson, Kathryn M, Georg, Gunda I, Fine, Jared M, Svitak, Aleta L, Faltesek, Katherine A, Hanson, Leah R, Mishra, Usha, Coles, Lisa D, Cloyd, James C, Siegel, Ronald A

“…Intranasal administration is an attractive route for systemic delivery of small, lipophilic drugs because they are rapidly absorbed through the nasal mucosa…”
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Conspecific cueing in the sea lamprey: do reproductive migrations consistently follow the most intense larval odour? by Wagner, C. Michael, Twohey, Michael B., Fine, Jared M.

“…Conspecific cueing occurs when an organism receives information about habitat quality from the distribution of conspecifics. Consequently, animals should…”
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Intranasal administration of CNS therapeutics to awake mice by Hanson, Leah R, Fine, Jared M, Svitak, Aleta L, Faltesek, Katherine A

“…Intranasal administration is a method of delivering therapeutic agents to the central nervous system (CNS). It is non-invasive and allows large molecules that…”
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Quantifying Intranasally Administered Deferoxamine in Rat Brain Tissue with Mass Spectrometry by Kosyakovsky, Jacob, Witthuhn, Bruce A, Svitak, Aleta L, Frey, William H, Hanson, Leah R, Fine, Jared M

“…Deferoxamine, a metal chelator, has been shown to be neuroprotective in animal models of ischemic stroke, traumatic brain injury and both subarachnoid and…”
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Food consumption and activity levels increase in rats following intranasal Hypocretin-1 by Dhuria, Shyeilla V., Fine, Jared M., Bingham, Deborah, Svitak, Aleta L., Burns, Rachel B., Baillargeon, Amanda M., Panter, Scott S., Kazi, Abdul N., Frey, William H., Hanson, Leah R.

“…•Intranasal HC distribution to brain and peripheral tissue is dose-dependent.•Intranasal HC increases food intake and activity immediately but not…”
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Evidence that petromyzontid lampreys employ a common migratory pheromone that is partially comprised of bile acids by FINE, Jared M, VRIEZE, Lance A, SORENSEN, Peter W

“…This study examined whether the larval pheromone employed by adult sea lamprey (Petromyzon marinus) to locate spawning streams and known to be at least…”
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Intranasal deferoxamine prevents memory loss in the intracerebroventricular streptozotocin rat model of Alzheimer’s disease by Fine, Jared M, Forsberg, Anna C, Stroebel, Benjamin M, Verden, Dylan R, Hamel, Katherine A, Raney, Elise B, Frey, William H, Hanson, Leah R

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Intranasal delivery of growth differentiation factor 5 to the central nervous system by Hanson, Leah R, Fine, Jared M, Hoekman, John D, Nguyen, Thuhien M, Burns, Rachel B, Martinez, Paula M, Pohl, Jens, Frey, 2nd, William H

“…Growth differentiation factor 5 (GDF5), in addition to its role in bone and joint development, protects dopaminergic (DA) neurons from degeneration, and is a…”
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Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice by Hanson, Leah R., Fine, Jared M., Renner, Dan B., Svitak, Aleta L., Burns, Rachel B., Nguyen, Thuhien M., Tuttle, Nathan J., Marti, Dianne L., Panter, S. Scott, Frey, William H.

“…Intranasal administration, which bypasses the blood–brain barrier and minimizes systemic exposure, is a non-invasive alternative for targeted drug delivery to…”
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Biologically relevant concentrations of petromyzonol sulfate, a component of the sea lamprey migratory pheromone, measured in stream water by FINE, Jared M, SORENSEN, Peter W

“…Adult sea lampreys locate spawning streams in the Great Lakes by using a migratory pheromone that is released by stream-resident larval conspecifics…”
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