Search Results - "Findlow, Stuart C."

Structure and Malonyl CoA-ACP Transacylase Binding of Streptomyces coelicolor Fatty Acid Synthase Acyl Carrier Protein by Arthur, Christopher J, Williams, Christopher, Pottage, Katherine, Płoskoń, Eliza, Findlow, Stuart C, Burston, Steven G, Simpson, Thomas J, Crump, Matthew P, Crosby, John

“…Malonylation of an acyl carrier protein (ACP) by malonyl Coenzyme A-ACP transacylase (MCAT) is fundamental to bacterial fatty acid biosynthesis. Here, we…”
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Structure of an Allosteric Inhibitor of LFA-1 Bound to the I-Domain Studied by Crystallography, NMR, and Calorimetry by Crump, Matthew P, Ceska, Thomas A, Spyracopoulos, Leo, Henry, Alistair, Archibald, Sarah C, Alexander, Rikki, Taylor, Richard J, Findlow, Stuart C, O'Connell, James, Robinson, Martyn K, Shock, Anthony

“…LFA-1 (lymphocyte function-associated antigen-1) plays a role in intercellular adhesion and lymphocyte trafficking and activation and is an attractive…”
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Evidence for Plasticity and Structural Mimicry at the Immunoglobulin Light Chain-Protein L Interface by Graille, Marc, Harrison, Steven, Crump, Matthew P., Findlow, Stuart C., Housden, Nicholas G., Muller, Bruno H., Battail-Poirot, Nicole, Sibaı̈, Geneviève, Sutton, Brian J., Taussig, Michael J., Jolivet-Reynaud, Colette, Gore, Michael G., Stura, Enrico A.

“…The multidomain bacterial surface protein L (PpL) is a virulence factor expressed by only 10% ofPeptostreptococcus magnus strains, and its expression is…”
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Solution Structure and Dynamics of Oxytetracycline Polyketide Synthase Acyl Carrier Protein from Streptomyces rimosus by Findlow, Stuart C, Winsor, Claire, Simpson, Thomas J, Crosby, John, Crump, Matthew P

“…Type II polyketide synthases (PKSs) utilize a dedicated and essential acyl carrier protein (ACP) in the biosynthesis of a specific polyketide product. As part…”
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Self-Malonylation Is an Intrinsic Property of a Chemically Synthesized Type II Polyketide Synthase Acyl Carrier Protein by Arthur, Christopher J, Szafranska, Anna, Evans, Simon E, Findlow, Stuart C, Burston, Steven G, Owen, Philip, Clark-Lewis, Ian, Simpson, Thomas J, Crosby, John, Crump, Matthew P

“…During polyketide biosynthesis, malonyl groups are transferred to the acyl carrier protein (ACP) component of the polyketide synthase (PKS), and it has been…”
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The Malonyl Transferase Activity of Type II Polyketide Synthase Acyl Carrier Proteins by Arthur, Christopher J., Szafranska, Anna E., Long, Jed, Mills, Jane, Cox, Russell J., Findlow, Stuart C., Simpson, Thomas J., Crump, Matthew P., Crosby, John

“…Acyl carrier proteins (ACPs) play a fundamental role in directing intermediates among the enzyme active sites of fatty acid and polyketide synthases (PKSs). In…”
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A Method for Identification of Inhibitors of the Phosphorylation Reactions of Bacterial Response Regulator Proteins Using 31P Nuclear Magnetic Resonance Spectroscopy by Hubbard, Julia A., MacLachlan, Lesley K., Johnson, Peter, Findlow, Stuart C., Ladds, Joanne C., Lewis, Ceri J., Carter, Paul S., Jones, Jo J., Fosberry, Andrew P.

“…Bacterial response regulators are attractive targets for antibacterial drug development, yet random screening against these targets has failed as yet to…”
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A method for identification of inhibitors of the phosphorylation reactions of bacterial response regulator proteins using (31)P nuclear magnetic resonance spectroscopy by Hubbard, J A, MacLachlan, L K, Johnson, P, Findlow, S C, Ladds, J C, Lewis, C J, Carter, P S, Jones, J J, Fosberry, A P

“…Bacterial response regulators are attractive targets for antibacterial drug development, yet random screening against these targets has failed as yet to…”
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Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins by Cox, Russell J, Hitchman, Timothy S, Byrom, Kate J, Findlow, I.Stuart C, Tanner, Julian A, Crosby, John, Simpson, Thomas J

“…Expression in Escherichia coli of Streptomyces acyl carrier proteins (ACPs) associated with polyketide biosynthesis using the pT7-7 expression system of Tabor…”
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Acylation of Streptomyces type II polyketide synthase acyl carrier proteins by Crosby, John, Byrom, Kate J, Hitchman, Timothy S, Cox, Russell J, Crump, Matthew P, Findlow, I.Stuart C, Bibb, Maureen J, Simpson, Thomas J

“…Acyl derivatives of type II PKS ACPs are required for in vitro studies of polyketide biosynthesis. The presence of an exposed cysteine residue prevented…”
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