Search Results - "Findlay, Kirk"

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity by Koo, Edward H, Weggen, Sascha, Eriksen, Jason L, Das, Pritam, Sagi, Sarah A, Wang, Rong, Pietrzik, Claus U, Findlay, Kirk A, Smith, Tawnya E, Murphy, Michael P, Bulter, Thomas, Kang, David E, Marquez-Sterling, Numa, Golde, Todd E

“…Epidemiological studies have documented a reduced prevalence of Alzheimer's disease among users of nonsteroidal anti-inflammatory drugs (NSAIDs). It has been…”
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Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors by Webb, Robin L, Findlay, Kirk A, Green, Michael A, Beckett, Tina L, Murphy, M Paul

“…Over the last decade a number of species, from farm animals to rodents, have been cloned using somatic cell nuclear transfer technology (SCNT). This technique…”
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Cell‐free assays for γ‐secretase activity by McLendon, Chris, Xin, TianPei, Ziani-Cherif, Chewki, Murphy, M. Paul, Findlay, Kirk A., Lewis, Patrick A., Pinnix, Inga, Sambamurti, Kumar, Wang, Rong, Fauq, Abdul, Golde, Todd E.

“…ABSTRACT The amyloid β‐protein (Aβ) deposited in Alzheimer's disease (AD) is a normally secreted proteolytic product of the amyloid β‐protein precursor (APP)…”
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A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch by Amtul, Zareen, Lewis, Patrick A., Piper, Sian, Crook, Richard, Baker, Matt, Findlay, Kirk, Singleton, Andrew, Hogg, Marion, Younkin, Linda, Younkin, Steven G., Hardy, John, Hutton, Michael, Boeve, Bradley F., Tang-Wai, David, Golde, Todd E.

“…A novel presenilin 1 mutation, insR352, associated with a frontal temporal dementia phenotype has been identified (E. A. Rogaeva et al., 2001, Neurology 57,…”
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Interaction of BP180 (Type XVII Collagen) and α6 Integrin is Necessary for Stabilization of Hemidesmosome Structure by Hopkinson, Susan B., Findlay, Kirk, deHart, Gregory W., Jones, Jonathan C.R.

“…The hemidesmosome is a multimolecular complex that integrates the extracellular matrix with the keratin cytoskeleton and that stabilizes epithelial attachment…”
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Phagocytic processing of bacterial antigens for class I MHC presentation to T cells by Pfeifer, John D, Wick, Mary Jo, Roberts, Richard L, Findlay, Kirk, Normark, Staffan J, Harding, Clifford V

“…Class I major histocompatibility complex (MHC) molecules present antigens that are produced within the presenting cell or penetrate from the vacuolar system…”
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Plant-centered biosystems in space environments: technological concepts for developing a plant genetic assessment and control system by Lomax, Terri L, Findlay, Kirk A, White, T J, Winner, William E

“…Plants will play an essential role in providing life support for any long-term space exploration or habitation. We are evaluating the feasibility of an…”
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Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage by Murphy, M P, Uljon, S N, Fraser, P E, Fauq, A, Lookingbill, H A, Findlay, K A, Smith, T E, Lewis, P A, McLendon, D C, Wang, R, Golde, T E

“…Presenilins (PSs) are polytopic membrane proteins that have been implicated as potential therapeutic targets in Alzheimer's disease because of their role in…”
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Processing of exogenous liposome-encapsulated antigens in vivo generates class I MHC-restricted T cell responses by Collins, DS, Findlay, K, Harding, CV

“…Acid-sensitive liposomes have been developed for cytosolic delivery of encapsulated substances. We now demonstrate delivery of liposome-encapsulated Ag into…”
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Reply by Jones, Jonathan, Hopkinson, Susan, deHart, Gregory, Findlay, Kirk

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Molecular targets for the inhibition of Aβ production by Murphy, Michael P., McLendon, Daniel C., A. Findlay, Kirk, Smith, Tawnya E., Ziani-Cherif, Chewski, Fauq, Abduli

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Presenilns regulators of γ-secretase cleavage by Golde, Todd E., Findlay, Kirk A., Smith, Tawnya E., Thompson, Sylvie, McLendon, Daniel C., Wang, Rong, Murphy, Michael P.

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Evidence that BPAG2 interacts with α6 integrin: Perturbation of this association inhibits hemidesmosome assembly by Hopkinson, Susan B., Findlay, Kirk, Jones, Jonathan C.R.

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Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities by Murphy, M. Paul, Uljon, Sacha N., Fraser, Paul E., Fauq, Abdul, Lookingbill, Hilary A., Findlay, Kirk A., Smith, Tawnya E., Lewis, Patrick A., McLendon, D. Chris, Wang, Rong, Golde, Todd E.

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Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities by M. Paul Murphy, Sacha N. Uljon, Paul E. Fraser, Abdul Fauq, Hilary A. Lookingbill, Kirk A. Findlay, Tawnya E. Smith, Patrick A. Lewis, D. Chris McLendon, Rong Wang, Todd E. Golde

“…Presenilins (PSs) are polytopic membrane proteins that have been implicated as potential therapeutic targets in Alzheimer's disease because of their role in…”
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