Search Results - "Findlay, John B C"

Production of functional human vitamin A transporter/RBP receptor (STRA6) for structure determination by Breen, Conor J, Martin, Darren S, Ma, Hui, McQuaid, Kate, O'Kennedy, Richard, Findlay, John B C

“…STRA6 is a plasma membrane protein that mediates the transport of vitamin A, or retinol, from plasma retinol binding protein (RBP) into the cell. Mutations in…”
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The effect of retinol binding protein on the proteome of C2C12 muscle cells by Young, Pamela A., Leonard, Siobhán, Martin, Darren S. D., Findlay, John B. C.

“…Background Retinol binding protein (RBP) and its membrane receptor, STRA6, are vital for the management of vitamin A in the body. Recently, elevated serum RBP…”
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Proteomic Screening of a Cell Line Model of Esophageal Carcinogenesis Identifies Cathepsin D and Aldo-Keto Reductase 1C2 and 1B10 Dysregulation in Barrett’s Esophagus and Esophageal Adenocarcinoma by Breton, Jean, Gage, Matthew C, Hay, Alastair W, Keen, Jeffrey N, Wild, Christopher P, Donnellan, Clare, Findlay, John B. C, Hardie, Laura J

“…Esophageal adenocarcinoma (EA) incidence is increasing rapidly and is associated with a poor prognosis. Identifying biomarkers of disease development and…”
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Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein by Bingham, Richard J., Findlay, John B. C., Hsieh, Shih-Yang, Kalverda, Arnout P., Kjellberg, Alexandra, Perazzolo, Chiara, Phillips, Simon E. V., Seshadri, Kothandaraman, Trinh, Chi H., Turnbull, W. Bruce, Bodenhausen, Geoffrey, Homans, Steve W.

“…In the present study we examine the thermodynamics of binding of two related pyrazine-derived ligands to the major urinary protein, MUP-I, using a combination…”
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Expression and structural characterization of peripherin/RDS, a membrane protein implicated in photoreceptor outer segment morphology by Vos, Werner Louwrens, Vaughan, Sebastian, Lall, Patrick Y, McCaffrey, John G, Wysocka-Kapcinska, Monika, Findlay, John B. C

“…Peripherin/RDS is a member of the tetraspanin family of integral membrane proteins and plays a major role in the morphology of photoreceptor outer segments…”
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Defined Sites of Interaction between Subunits E (Vma4p), C (Vma5p), and G (Vma10p) within the Stator Structure of the Vacuolar H+-ATPase by Jones, Richard P. O, Durose, Lyndsey J, Findlay, John B. C, Harrison, Michael A

“…Vacuolar H+-ATPases (V-ATPases) are multi-subunit membrane proteins that couple ATP hydrolysis to the extrusion of protons from the cytoplasm. Although they…”
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Identification of the retinol-binding protein (RBP) interaction site and functional state of RBPs for the membrane receptor by Redondo, Clara, Vouropoulou, Maria, Evans, Jonathan, Findlay, John B.C

“…This laboratory has advanced a model whereby retinol is transported around the body bound to retinol-binding protein (RBP), is transferred across the membrane…”
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Analysis of the effect of a novel therapeutic for type 2 diabetes on the proteome of a muscle cell line by Young, Pamela A., Leonard, Siobhán, Martin, Darren S. D., Findlay, John B. C.

“…Elevated serum retinol‐binding protein (RBP) concentration has been implicated in the development of insulin resistance and type 2 diabetes. Two series of…”
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Fenretinide Derivatives Act as Disrupters of Interactions of Serum Retinol Binding Protein (sRBP) with Transthyretin and the sRBP Receptor by Campos-Sandoval, José Angel, Redondo, Clara, Kinsella, Gemma K, Pal, Akos, Jones, Geraint, Eyre, Gwen S, Hirst, Simon C, Findlay, John B. C

“…Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Elevated…”
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An analysis of the phosphoproteome of immune cell lines exposed to the immunomodulatory mycotoxin deoxynivalenol by Nogueira da Costa, André, Keen, Jeffrey N., Wild, Christopher P., Findlay, John B.C.

“…The mycotoxin deoxynivalenol (DON) commonly contaminates cereal grains. It is ubiquitous in the Western European diet, although chronic, low-dose effects in…”
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Incorporation of Transmembrane Peptides from the Vacuolar H+-ATPase in Phospholipid Membranes: Spin-Label Electron Paramagnetic Resonance and Polarized Infrared Spectroscopy by Kóta, Zoltán, Páli, Tibor, Dixon, Neil, Kee, Terry P, Harrison, Michael A, Findlay, John B. C, Finbow, Malcolm E, Marsh, Derek

“…Peptides were designed that are based on candidate transmembrane sequences of the Vo-sector from the vacuolar H+-ATPase of Saccharomyces cerevisiae. Spin-label…”
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G protein–coupled receptor 21 in macrophages: An in vitro study by Bordano, Valentina, Kinsella, Gemma K., Cannito, Stefania, Dianzani, Chiara, Gigliotti, Casimiro Luca, Stephens, John C., Monge, Chiara, Bocca, Claudia, Rosa, Arianna C., Miglio, Gianluca, Dianzani, Umberto, Findlay, John B.C., Benetti, Elisa

“…GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein Coupled Receptors (GPCRs). GPR21 couples to the Gq family of G…”
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GPR21 Inhibition Increases Glucose-Uptake in HepG2 Cells by Kinsella, Gemma K., Cannito, Stefania, Bordano, Valentina, Stephens, John C., Rosa, Arianna C., Miglio, Gianluca, Guaschino, Valeria, Iannaccone, Valeria, Findlay, John B.C., Benetti, Elisa

“…GPR21 is a constitutively active, orphan, G-protein-coupled receptor, with in vivo studies suggesting its involvement in the modulation of insulin sensitivity…”
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Regulating the effects of GPR21, a novel target for type 2 diabetes by Leonard, Siobhán, Kinsella, Gemma K., Benetti, Elisa, Findlay, John B. C.

“…Type 2 diabetes is a chronic metabolic disorder primarily caused by insulin resistance to which obesity is a major contributor. Expression levels of an orphan…”
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The signalling mechanisms of a novel mitochondrial complex I inhibitor prevent lipid accumulation and attenuate TNF-α-induced insulin resistance in vitro by Leonard, Siobhán, Tobin, Laura M., Findlay, John B.C.

“…RTC-1 has recently been identified as a member of a new class of anti-diabetic compounds acting through the inhibition of complex I of the mitochondrial…”
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Concanamycin and Indolyl Pentadieneamide Inhibitors of the Vacuolar H+-ATPase Bind with High Affinity to the Purified Proteolipid Subunit of the Membrane Domain by Whyteside, Graham, Meek, Peter J, Ball, Stephen K, Dixon, Neil, Finbow, Malcolm E, Kee, Terence P, Findlay, John B. C, Harrison, Michael A

“…The macrolide antibiotic concanamycin is a potent and specific inhibitor of the vacuolar H+-ATPase (V-ATPase), binding to the V0 membrane domain of this…”
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Interaction of Inhibitors of the Vacuolar H+-ATPase with the Transmembrane Vo-Sector by Páli, Tibor, Whyteside, Graham, Dixon, Neil, Kee, Terence P, Ball, Stephen, Harrison, Michael A, Findlay, John B. C, Finbow, Malcolm E, Marsh, Derek

“…The macrolide antibiotic concanamycin A and a designed derivative of 5-(2-indolyl)-2,4-pentadienamide (INDOL0) are potent inhibitors of vacuolar H+-ATPases,…”
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Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography by Böcskei, Zsolt, Groom, Colin R, Flower, Darren R, Wright, Charles E, Phillips, Simon E. V, Cavaggioni, Andrea, Findlay, John B. C, North, Anthony C. T

“…The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well…”
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Expression, characterization and ligand specificity of lipocalin-1 interacting membrane receptor (LIMR) by Hesselink, Renske W, Findlay, John B C

“…Human lipocalin-1 interacting membrane receptor (LIMR) was the first lipocalin receptor to be identified, as a specific receptor for lipocalin-1 (Lcn1)…”
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The melanocortin 4 receptor: Oligomer formation, interaction sites and functional significance by Chapman, Kathryn L., Findlay, John B.C.

“…This study involves the structural and functional properties of the recombinant melanocortin 4 receptor (MC4R) expressed in the HEK-293 cell line. Using…”
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