Search Results - "Findlay, B."

Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741 by Delaunoit, T., Alberts, S. R., Sargent, D. J., Green, E., Goldberg, R. M., Krook, J., Fuchs, C., Ramanathan, R. K., Williamson, S. K., Morton, R. F., Findlay, B. P.

“…Background: Fluorouracil (5-FU), oxaliplatin and irinotecan combinations improve time to tumor progression (TTP), objective response and overall survival (OS)…”
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Prospective Cost-Effectiveness Analysis of Cetuximab in Metastatic Colorectal Cancer: Evaluation of National Cancer Institute of Canada Clinical Trials Group CO.17 Trial by Mittmann, Nicole, Au, Heather-Jane, Tu, Dongsheng, O'Callaghan, Christopher J., Isogai, Pierre K., Karapetis, Christos S., Zalcberg, John R., Evans, William K., Moore, Malcolm J., Siddiqui, Jehan, Findlay, Brian, Colwell, Bruce, Simes, John, Gibbs, Peter, Links, Matthew, Tebbutt, Niall C., Jonker, Derek J.

“…Background The National Cancer Institute of Canada Clinical Trials Group CO.17 study showed that patients with advanced colorectal cancer had improved overall…”
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Production of functional human vitamin A transporter/RBP receptor (STRA6) for structure determination by Breen, Conor J, Martin, Darren S, Ma, Hui, McQuaid, Kate, O'Kennedy, Richard, Findlay, John B C

“…STRA6 is a plasma membrane protein that mediates the transport of vitamin A, or retinol, from plasma retinol binding protein (RBP) into the cell. Mutations in…”
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The effect of retinol binding protein on the proteome of C2C12 muscle cells by Young, Pamela A., Leonard, Siobhán, Martin, Darren S. D., Findlay, John B. C.

“…Background Retinol binding protein (RBP) and its membrane receptor, STRA6, are vital for the management of vitamin A in the body. Recently, elevated serum RBP…”
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Impaired brachial artery flow-mediated vasodilation in response to handgrip exercise-induced increases in shear stress in young smokers by Findlay, Briar B, Gupta, Parnika, Szijgyarto, Ingrid C, Pyke, Kyra E

“…Smoking is an established risk factor for cardiovascular disease. It has also been shown to result in endothelial dysfunction as assessed by flow-mediated…”
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Proteomic Screening of a Cell Line Model of Esophageal Carcinogenesis Identifies Cathepsin D and Aldo-Keto Reductase 1C2 and 1B10 Dysregulation in Barrett’s Esophagus and Esophageal Adenocarcinoma by Breton, Jean, Gage, Matthew C, Hay, Alastair W, Keen, Jeffrey N, Wild, Christopher P, Donnellan, Clare, Findlay, John B. C, Hardie, Laura J

“…Esophageal adenocarcinoma (EA) incidence is increasing rapidly and is associated with a poor prognosis. Identifying biomarkers of disease development and…”
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Identification of the retinol-binding protein (RBP) interaction site and functional state of RBPs for the membrane receptor by Redondo, Clara, Vouropoulou, Maria, Evans, Jonathan, Findlay, John B.C

“…This laboratory has advanced a model whereby retinol is transported around the body bound to retinol-binding protein (RBP), is transferred across the membrane…”
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Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein by Bingham, Richard J., Findlay, John B. C., Hsieh, Shih-Yang, Kalverda, Arnout P., Kjellberg, Alexandra, Perazzolo, Chiara, Phillips, Simon E. V., Seshadri, Kothandaraman, Trinh, Chi H., Turnbull, W. Bruce, Bodenhausen, Geoffrey, Homans, Steve W.

“…In the present study we examine the thermodynamics of binding of two related pyrazine-derived ligands to the major urinary protein, MUP-I, using a combination…”
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randomized, placebo-controlled trial (NCIC CTG MAP1) examining the effects of letrozole on mammographic breast density and other end organs in postmenopausal women by Cigler, T, Tu, D, Yaffe, M. J, Findlay, B, Verma, S, Johnston, D, Richardson, H, Hu, H, Qi, S, Goss, P. E

“…Mammographically detected breast density has been correlated with breast cancer risk. Breast density appears to be influenced by hormonal factors including…”
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Fenretinide Derivatives Act as Disrupters of Interactions of Serum Retinol Binding Protein (sRBP) with Transthyretin and the sRBP Receptor by Campos-Sandoval, José Angel, Redondo, Clara, Kinsella, Gemma K, Pal, Akos, Jones, Geraint, Eyre, Gwen S, Hirst, Simon C, Findlay, John B. C

“…Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Elevated…”
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Phase III Comparative Study of Vinorelbine Combined With Doxorubicin Versus Doxorubicin Alone in Disseminated Metastatic/Recurrent Breast Cancer: National Cancer Institute of Canada Clinical Trials Group Study MA8 by NORRIS, B, PRITCHARD, K. I, LATREILLE, J, RUDINSKAS, L, LOFTERS, W, TRUDEAU, M, OSOBA, D, RODGERS, A, JAMES, K, MYLES, J, BENNETT, K, MARLIN, S, SKILLINGS, J, FINDLAY, B, VANDENBERG, T, GOSS, P

“…This phase III study was performed to determine the superiority of doxorubicin (DOX) and vinorelbine (VNB) (arm 1) versus DOX alone (arm 2) in metastatic…”
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Analysis of the effect of a novel therapeutic for type 2 diabetes on the proteome of a muscle cell line by Young, Pamela A., Leonard, Siobhán, Martin, Darren S. D., Findlay, John B. C.

“…Elevated serum retinol‐binding protein (RBP) concentration has been implicated in the development of insulin resistance and type 2 diabetes. Two series of…”
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An analysis of the phosphoproteome of immune cell lines exposed to the immunomodulatory mycotoxin deoxynivalenol by Nogueira da Costa, André, Keen, Jeffrey N., Wild, Christopher P., Findlay, John B.C.

“…The mycotoxin deoxynivalenol (DON) commonly contaminates cereal grains. It is ubiquitous in the Western European diet, although chronic, low-dose effects in…”
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Expression and structural characterization of peripherin/RDS, a membrane protein implicated in photoreceptor outer segment morphology by Vos, Werner Louwrens, Vaughan, Sebastian, Lall, Patrick Y, McCaffrey, John G, Wysocka-Kapcinska, Monika, Findlay, John B. C

“…Peripherin/RDS is a member of the tetraspanin family of integral membrane proteins and plays a major role in the morphology of photoreceptor outer segments…”
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Defined Sites of Interaction between Subunits E (Vma4p), C (Vma5p), and G (Vma10p) within the Stator Structure of the Vacuolar H+-ATPase by Jones, Richard P. O, Durose, Lyndsey J, Findlay, John B. C, Harrison, Michael A

“…Vacuolar H+-ATPases (V-ATPases) are multi-subunit membrane proteins that couple ATP hydrolysis to the extrusion of protons from the cytoplasm. Although they…”
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Incorporation of Transmembrane Peptides from the Vacuolar H+-ATPase in Phospholipid Membranes: Spin-Label Electron Paramagnetic Resonance and Polarized Infrared Spectroscopy by Kóta, Zoltán, Páli, Tibor, Dixon, Neil, Kee, Terry P, Harrison, Michael A, Findlay, John B. C, Finbow, Malcolm E, Marsh, Derek

“…Peptides were designed that are based on candidate transmembrane sequences of the Vo-sector from the vacuolar H+-ATPase of Saccharomyces cerevisiae. Spin-label…”
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Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography by Böcskei, Zsolt, Groom, Colin R, Flower, Darren R, Wright, Charles E, Phillips, Simon E. V, Cavaggioni, Andrea, Findlay, John B. C, North, Anthony C. T

“…The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well…”
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G protein–coupled receptor 21 in macrophages: An in vitro study by Bordano, Valentina, Kinsella, Gemma K., Cannito, Stefania, Dianzani, Chiara, Gigliotti, Casimiro Luca, Stephens, John C., Monge, Chiara, Bocca, Claudia, Rosa, Arianna C., Miglio, Gianluca, Dianzani, Umberto, Findlay, John B.C., Benetti, Elisa

“…GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein Coupled Receptors (GPCRs). GPR21 couples to the Gq family of G…”
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GPR21 Inhibition Increases Glucose-Uptake in HepG2 Cells by Kinsella, Gemma K., Cannito, Stefania, Bordano, Valentina, Stephens, John C., Rosa, Arianna C., Miglio, Gianluca, Guaschino, Valeria, Iannaccone, Valeria, Findlay, John B.C., Benetti, Elisa

“…GPR21 is a constitutively active, orphan, G-protein-coupled receptor, with in vivo studies suggesting its involvement in the modulation of insulin sensitivity…”
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Regulating the effects of GPR21, a novel target for type 2 diabetes by Leonard, Siobhán, Kinsella, Gemma K., Benetti, Elisa, Findlay, John B. C.

“…Type 2 diabetes is a chronic metabolic disorder primarily caused by insulin resistance to which obesity is a major contributor. Expression levels of an orphan…”
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