Search Results - "Findeis, Mark A."

Molecular mechanism of phosphopeptide neoantigen immunogenicity by Patskovsky, Yury, Natarajan, Aswin, Patskovska, Larysa, Nyovanie, Samantha, Joshi, Bishnu, Morin, Benjamin, Brittsan, Christine, Huber, Olivia, Gordon, Samuel, Michelet, Xavier, Schmitzberger, Florian, Stein, Robert B., Findeis, Mark A., Hurwitz, Andy, Van Dijk, Marc, Chantzoura, Eleni, Yague, Alvaro S., Pollack Smith, Daniel, Buell, Jennifer S., Underwood, Dennis, Krogsgaard, Michelle

“…Altered protein phosphorylation in cancer cells often leads to surface presentation of phosphopeptide neoantigens. However, their role in cancer immunogenicity…”
Get full text

Author Correction: Molecular mechanism of phosphopeptide neoantigen immunogenicity by Patskovsky, Yury, Natarajan, Aswin, Patskovska, Larysa, Nyovanie, Samantha, Joshi, Bishnu, Morin, Benjamin, Brittsan, Christine, Huber, Olivia, Gordon, Samuel, Michelet, Xavier, Schmitzberger, Florian, Stein, Robert B., Findeis, Mark A., Hurwitz, Andy, Van Dijk, Marc, Chantzoura, Eleni, Yague, Alvaro S., Pollack Smith, Daniel, Buell, Jennifer S., Underwood, Dennis, Krogsgaard, Michelle

Get full text

The role of amyloid beta peptide 42 in Alzheimer's disease by Findeis, Mark A

“…During the last 20 years, an expanding body of research has elucidated the central role of amyloid precursor protein (APP) processing and amyloid beta peptide…”
Get full text

Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody by Gombos, Randi B, Gonzalez, Ana, Manrique, Mariana, Chand, Dhan, Savitsky, David, Morin, Benjamin, Breous-Nystrom, Ekaterina, Dupont, Christopher, Ward, Rebecca A, Mundt, Cornelia, Duckless, Benjamin, Tang, Hao, Findeis, Mark A, Schuster, Andrea, Waight, Jeremy D, Underwood, Dennis, Clarke, Christopher, Ritter, Gerd, Merghoub, Taha, Schaer, David, Wolchok, Jedd D, van Dijk, Marc, Buell, Jennifer S, Cuillerot, Jean-Marie, Stein, Robert, Drouin, Elise E, Wilson, Nicholas S

“…CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with…”
Get full text

Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa by Findeis, Mark A, Schroeder, Frank, McKee, Timothy D, Yager, Debra, Fraering, Patrick C, Creaser, Steffen P, Austin, Wesley F, Clardy, Jon, Wang, Rong, Selkoe, Dennis, Eckman, Christopher B

“…A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein…”
Get full text

Targeted Delivery of DNA Using YEE(GalNAcAH)3, a Synthetic Glycopeptide Ligand for the Asialoglycoprotein Receptor by Merwin, June Rae, Noell, G. Stephen, Thomas, Wendy L, Chiou, Henry C, DeRome, Mary E, McKee, Timothy D, Spitalny, George L, Findeis, Mark A

“…In vivo gene therapy shows promise as a treatment for both genetic and acquired disorders. The hepatic asialoglycoprotein receptor (ASGPr) binds…”
Get full text

Multikilogram-Scale Production of Cycloartenol Triterpenoid Glycosides as Synthetic Intermediates for a γ‑Secretase Modulator by Shen, Ruichao, Fuller, Nathan O, Osswald, Gerd, Austin, Wesley F, Hubbs, Jed L, Haag, Dieter, Kovacs, Janos, Creaser, Steffen P, Findeis, Mark A, Ives, Jeffrey L, Bronk, Brian S

“…The process development and production of two cycloartenol triterpenoid glycosides on a multikilogram scale are described. The two compounds were used as key…”
Get full text

Peptide inhibitors of beta amyloid aggregation by Findeis, Mark A

“…Amyloid beta peptide (Abeta) is implicated in the pathogenesis of Alzheimer s disease (AD), particularly as oligomers or polymers that are correlated with…”
Get more information

Initial Optimization of a New Series of γ‑Secretase Modulators Derived from a Triterpene Glycoside by Fuller, Nathan O, Hubbs, Jed L, Austin, Wesley F, Creaser, Steffen P, McKee, Timothy D, Loureiro, Robyn M. B, Tate, Barbara, Xia, Weiming, Ives, Jeffrey L, Findeis, Mark A, Bronk, Brian S

“…The discovery of a new series of γ-secretase modulators is disclosed. Starting from a triterpene glycoside γ-secretase modulator that gave a very low…”
Get full text

Modified-Peptide Inhibitors of Amyloid β-Peptide Polymerization by Findeis, Mark A, Musso, Gary M, Arico-Muendel, Christopher C, Benjamin, Howard W, Hundal, Arvind M, Lee, Jung-Ja, Chin, Joseph, Kelley, Michael, Wakefield, James, Hayward, Neil J, Molineaux, Susan M

“…Cellular toxicity resulting from nucleation-dependent polymerization of amyloid β-peptide (Aβ) is considered to be a major and possibly the primary component…”
Get full text

Natural Product and Natural Product-Derived Gamma Secretase Modulators from Actaea Racemosa Extracts by Findeis, Mark A, Schroeder, Frank C, Creaser, Steffen P, McKee, Timothy D, Xia, Weiming

“…Alzheimer's disease is characterized by pathogenic oligomerization, aggregation, and deposition of amyloid beta peptide (Aβ), resulting in severe neuronal…”
Get full text

Peptide and Protein Synthesis by Segment Synthesis-Condensation by Kaiser, Emil Thomas, Mihara, Hisakazu, Laforet, Genevieve A., Kelly, Jeffery W., Walters, Lee, Findeis, Mark A., Sasaki, Tomikazu

“…The chemical synthesis of biologically active peptides and polypeptides can be achieved by using a convergent strategy of condensing protected peptide segments…”
Get full text

Preparation of Asialoorosomucoid-Polylysine Conjugates by McKee, Timothy D., DeRome, Mary E., Wu, George Y., Findeis, Mark A.

“…Asialoorosomucoid-polylysine (ASOR-PL) conjugates have been recently developed as carriers of electrostatically bound DNA for targeted delivery to the hepatic…”
Get full text

Approaches to discovery and characterization of inhibitors of amyloid β-peptide polymerization by Findeis, Mark A.

“…Polymerization of the amyloid β-peptide (Aβ) has been identified as a major feature of the pathogenesis of Alzheimer’s disease (AD). Inhibition of the…”
Get full text

Evaluation of the oxime resin based segment synthesis-condensation approach using RNase T1 as a model synthetic target by Sasaki, Tomikazu, Findeis, Mark A., Kaiser, Emil Thomas

Get full text

Nitrobenzophenone oxime based resins for the solid-phase synthesis of protected peptide segments by Findeis, Mark A, Kaiser, Emil Thomas

Get full text

Fumarase-catalyzed synthesis of L-threo-chloromalic acid and its conversion to 2-deoxy-D-ribose and D-erythro-sphingosine by Findeis, Mark A, Whitesides, George M

Get full text

Stepwise synthesis of a GalNAc-containing cluster glycoside ligand of the asialoglycoprotein receptor by Findeis, M A

“…A series of peptidylglycoside derivatives, including the tris(GalNAc-aminohexyl) glycoside of tyrosyl(glutamyl)-glutamate (1) which is known to have…”
Get more information

Protein synthesis in cell-free reticulocyte lysates on multi-hour incubation by FINDEIS, M. A, WHITESIDES, G. M

“…Cell-free protein synthesis in rabbit reticulocyte lysate translation mixtures has been studied during multi-hour incubations. In an impaired lysate obtained…”
Get full text

An efficient chemical and enzymic synthesis of nicotinamide adenine dinucleotide (NAD+) by Walt, David R, Findeis, Mark A, Rios-Mercadillo, Victor M, Auge, Jacques, Whitesides, George M

Get full text