Search Results - "Finck, Brian"

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus by Ferguson, Daniel, Finck, Brian N.

“…Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease in the world, yet there are still no approved pharmacological…”
Get full text

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis by Finck, Brian N

“…Obesity, insulin resistance, and diabetes are strongly linked to the accumulation of excessive lipids in the liver parenchyma, a condition known as…”
Get full text

Mitochondrial pyruvate transport: a historical perspective and future research directions by McCommis, Kyle S, Finck, Brian N

“…Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid…”
Get more information

PPARs and nonalcoholic fatty liver disease by Liss, Kim H.H., Finck, Brian N.

“…Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver pathology ranging from simple steatosis to varying degrees of inflammation, hepatocyte…”
Get full text

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway by Peterson, Timothy R., Sengupta, Shomit S., Harris, Thurl E., Carmack, Anne E., Kang, Seong A., Balderas, Eric, Guertin, David A., Madden, Katherine L., Carpenter, Anne E., Finck, Brian N., Sabatini, David M.

“…The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy,…”
Get full text

Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor by Fang, Yuanying, Hegazy, Lamees, Finck, Brian N, Elgendy, Bahaa

“…Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and glucose homeostasis, hepatic inflammation, regeneration, and…”
Get full text

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling by McCommis, Kyle S., Chen, Zhouji, Fu, Xiaorong, McDonald, William G., Colca, Jerry R., Kletzien, Rolf F., Burgess, Shawn C., Finck, Brian N.

“…Pyruvate transport across the inner mitochondrial membrane is believed to be a prerequisite for gluconeogenesis in hepatocytes, which is important for the…”
Get full text

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells by Lam, Wing Y., Becker, Amy M., Kennerly, Krista M., Wong, Rachel, Curtis, Jonathan D., Llufrio, Elizabeth M., McCommis, Kyle S., Fahrmann, Johannes, Pizzato, Hannah A., Nunley, Ryan M., Lee, Jieun, Wolfgang, Michael J., Patti, Gary J., Finck, Brian N., Pearce, Erika L., Bhattacharya, Deepta

“…Durable antibody production after vaccination or infection is mediated by long-lived plasma cells (LLPCs). Pathways that specifically allow LLPCs to persist…”
Get full text

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH by Daemen, Sabine, Gainullina, Anastasiia, Kalugotla, Gowri, He, Li, Chan, Mandy M., Beals, Joseph W., Liss, Kim H., Klein, Samuel, Feldstein, Ariel E., Finck, Brian N., Artyomov, Maxim N., Schilling, Joel D.

“…Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat,…”
Get full text

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis by Wang, Shiyu, Chen, Zhouji, Lam, Vivian, Han, Jaeseok, Hassler, Justin, Finck, Brian N., Davidson, Nicholas O., Kaufman, Randal J.

“…The unfolded protein response (UPR) is a signaling pathway required to maintain endoplasmic reticulum (ER) homeostasis and hepatic lipid metabolism. Here, we…”
Get full text

The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism by Yiew, Nicole K H, Finck, Brian N

“…Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved process and aberrant pyruvate metabolism is associated with and…”
Get more information

A Role for Impaired RECK Activity in Metabolic Dysfunction-associated Steatotic Liver Disease by Finck, Brian N.

Get full text

Dual function lipin proteins and glycerolipid metabolism by Harris, Thurl E, Finck, Brian N

“…Lipin family proteins are emerging as crucial regulators of lipid metabolism. In triglyceride synthesis, lipins act as lipid phosphatase enzymes at the…”
Get full text

The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity by Gao, Su, Ghoshal, Sarbani, Zhang, Liyan, Stevens, Joseph R., McCommis, Kyle S., Finck, Brian N., Lopaschuk, Gary D., Butler, Andrew A.

“…The peptide hormone adropin regulates energy metabolism in skeletal muscle and plays important roles in the regulation of metabolic homeostasis. Besides…”
Get full text

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis by DeBosch, Brian J, Heitmeier, Monique R, Mayer, Allyson L, Higgins, Cassandra B, Crowley, Jan R, Kraft, Thomas E, Chi, Maggie, Newberry, Elizabeth P, Chen, Zhouji, Finck, Brian N, Davidson, Nicholas O, Yarasheski, Kevin E, Hruz, Paul W, Moley, Kelle H

“…Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to…”
Get more information

The PPAR regulatory system in cardiac physiology and disease by Finck, Brian N

“…Myocardial energy metabolism is an important determinant of cardiac structure and function. Modulating metabolism is therefore an attractive therapeutic avenue…”
Get full text

Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction by Kading, Jacqueline, Finck, Brian N., DeBosch, Brian J.

“…The pervasion of three daily meals and snacks is a relatively new introduction to our shared experience and is coincident with an epidemic rise in obesity and…”
Get full text

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway by Potthoff, Matthew J., Boney-Montoya, Jamie, Choi, Mihwa, He, Tianteng, Sunny, Nishanth E., Satapati, Santhosh, Suino-Powell, Kelly, Xu, H. Eric, Gerard, Robert D., Finck, Brian N., Burgess, Shawn C., Mangelsdorf, David J., Kliewer, Steven A.

“…Regulation of hepatic carbohydrate homeostasis is crucial for maintaining energy balance in the face of fluctuating nutrient availability. Here, we show that…”
Get full text

Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity by Lutkewitte, Andrew J, Finck, Brian N

“…Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway that has incredibly important structural functions as a…”
Get full text

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response by Potthoff, Matthew J, Inagaki, Takeshi, Satapati, Santhosh, Ding, Xunshan, He, Tianteng, Goetz, Regina, Mohammadi, Moosa, Finck, Brian N, Mangelsdorf, David J, Kliewer, Steven A, Burgess, Shawn C

“…The liver plays a crucial role in mobilizing energy during nutritional deprivation. During the early stages of fasting, hepatic glycogenolysis is a primary…”
Get full text