Search Results - "Finch, John T."

Image reconstructions of helical assemblies of the HIV-1 CA protein by Sundquist, Wesley I, Li, Su, Hill, Christopher P, Finch, John T

“…The type 1 human immunodeficiency virus (HIV-1) contains a conical capsid comprising ∼1,500 CA protein subunits, which organizes the viral RNA genome for…”
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Assembly and Analysis of Conical Models for the HIV-1 Core by Ganser, Barbie K., Li, Su, Klishko, Victor Y., Finch, John T., Sundquist, Wesley I.

“…The genome of the human immunodeficiency virus (HIV) is packaged within an unusual conical core particle located at the center of the infectious virion. The…”
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Rapid Amyloid Fiber Formation from the Fast-Folding WW Domain FBP28 by Ferguson, Neil, Berriman, John, Petrovich, Miriana, Sharpe, Timothy D., Finch, John T., Fersht, Alan R.

“…The WW domains are small proteins that contain a three-stranded, antiparallel β-sheet. The 40-residue murine FBP28 WW domain rapidly formed twirling…”
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The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition by Fairall, Louise, Schwabe, John W. R, Chapman, Lynda, Finch, John T, Rhodes, Daniela

“…The Cys2-His2 zinc-finger is the most widely occurring DNA-binding motif. The first structure of a zinc-finger/DNA complex revealed a fairly simple mechanism…”
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The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage by Scott, William G., Finch, John T., Klug, Aaron

“…We have solved the crystal structure of an all-RNA hammerhead ribozyme having a single 2′-O-methyl cytosine incorporated at the active site to prevent…”
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The structure of an oligo(dA)·oligo(dT) tract and its biological implications by Nelson, Hillary C. M, Finch, John T, Luisi, Bonaventura F, Klug, Aaron

“…Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of…”
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Glutamine Repeats as Polar Zippers: Their Possible Role in Inherited Neurodegenerative Diseases by Perutz, Max F., Johnson, Tony, Suzuki, Masashi, Finch, John T.

“…Four inherited neurodegenerative diseases are linked to abnormally expanded repeats of glutamine residues in the affected proteins. Molecular modeling followed…”
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The mechanism of Z α1-antitrypsin accumulation in the liver by LOMAS, D. A, EVANS, D. L, FINCH, J. T, CARRELL, R. W

“…MOST northern Europeans have only the normal M form of the plasma protease inhibitor α1,-antitrypsin, but some 4% are heterozygotes for the Z deficiency…”
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Binding of the dye congo red to the amyloid protein pig insulin reveals a novel homology amongst amyloid-forming peptide sequences by Turnell, W G, Finch, J T

“…The three-dimensional structure has been determined of a complex of the dye Congo Red, a specific stain for amyloid deposits, bound to the amyloid protein…”
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Crystal structure of ovalbumin as a model for the reactive centre of serpins by Stein, Penelope E, Leslie, Andrew G. W, Finch, John T, Turnell, William G, McLaughlin, Paul J, Carrell, Robin W

“…The serpins are a widely distributed family of proteins with diverse functions; they include the key serine protease inhibitors of human plasma as well as…”
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A spacer protein in the Saccharomyces cerevisiae spindle pole body whose transcript is cell cycle-regulated by Kilmartin, John V., Dyos, Susan L., Kershaw, Douglas, Finch, John T.

“…Monoclonal antibodies against the 110-kD component of the yeast spindle pole body (SPB) were used to clone the corresponding gene SPC110. SPC110 is identical…”
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Aaron Klug and the revolution in biomolecular structure determination by Amos, Linda A., Finch, John T.

“…Aaron Klug's group was one of the first to use a combination of X-ray diffraction and electron microscopy to study the structures of macromolecules. He helped…”
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DNA recognition by the oestrogen receptor: from solution to the crystal by Schwabe, J W, Chapman, L, Finch, J T, Rhodes, D, Neuhaus, D

“…The steroid/nuclear hormone receptors are a large family of conserved ligand-activated transcription factors that regulate gene expression through binding to…”
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Role of base-backbone and base-base interactions in alternating DNA conformations by Suzuki, Masashi, Yagi, Naoto, Finch, John T.

“…Sequence-specific conformational differences between dinucleotide steps are characterised using published crystal coordinates with special attention to steric…”
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Tramtrack co-operates to prevent inappropriate neural development in Drosophila by Badenhorst, Paul, Finch, John T., Travers, Andrew A.

“…Each sensory organ of the Drosophila peripheral nervous system is derived from a single sensory organ precursor cell (SOP). These originate in territories…”
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Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? by Jennings, P A, Finch, J T, Winter, G, Robertson, J S

“…Subgenomic RNAs (sgRNAs) were isolated from defective interfering virus produced by high multiplicity passage of the human influenza strain A/PR/8/34. Cloning…”
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Familial dementia caused by polymerization of mutant neuroserpin by Gooptu, Bibek, Sonderegger, Peter, Lacbawan, Felicitas, Lawrence, Daniel A, Davis, Richard L, Becker, Lyn Marie, Yerby, Mark S, Krasnewich, Donna, Holohan, Peter D, Collins, George H, Shaw, Cheng-Mei, Muenke, Maximilian, Kinter, Jochen, Elliott, Peter R, Feiglin, David, Lomas, David A, Shrimpton, Antony E, Finch, John T, Carrell, Robin W, Bradshaw, Charles

“…Aberrant protein processing with tissue deposition is associated with many common neurodegenerative disorders; however, the complex interplay of genetic and…”
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The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements by Schwabe, J W, Chapman, L, Finch, J T, Rhodes, D

“…The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the crystal structure (at 2.4 A) of…”
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The mechanism of Z α 1 -antitrypsin accumulation in the liver by Lomas, David A, LI-Evans, Dyfed, Finch, John T, Carrell, Robin W

“…Most northern Europeans have only the normal M form of the plasma protease inhibitor alpha 1-antitrypsin, but some 4% are heterozygotes for the Z deficiency…”
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Structure and symmetry of B. stearothermophilus pyruvate dehydrogenase multienzyme complex and implications for eucaryote evolution by Henderson, C E, Perham, R N, Finch, J T

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