Search Results - "Finbloom, DS"

Differential regulation of IL-1 production in human monocytes by IFN- gamma and IL-4 by Donnelly, RP, Fenton, MJ, Finbloom, DS, Gerrard, TL

“…We have demonstrated that IL-4 markedly inhibits IL-1 production by highly purified normal human monocytes. When added to monocyte cultures, IL-4 suppressed…”
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IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes by Finbloom, DS, Winestock, KD

“…IL-10 affects monocytes and T cells by driving the progression of immune responsiveness such that Th2 lymphocyte-mediated effects predominate. In this report,…”
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The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes by Donnelly, R P, Dickensheets, H, Finbloom, D S

“…Interleukin-10 (IL-10) activates a diverse array of functional responses in mononuclear phagocytes. Functional IL-10 receptor (IL-10R) complexes are tetramers…”
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An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction by Nakajima, Hiroshi, Liu, Xiu-Wen, Wynshaw-Boris, Anthony, Rosenthal, Louis A, Imada, Kazunori, Finbloom, David S, Hennighausen, Lothar, Leonard, Warren J

“…Stat5a was identified as a prolactin-induced transcription factor but also is activated by other cytokines, including interleukin-2 (IL-2) and IL-7. We have…”
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STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression by FELDMAN, G. M, ROSENTHAL, L. A, LIU, X, HAYES, M. P, WYNSHAW-BORIS, A, LEONARD, W. J, HENNIGHAUSEN, L, FINBLOOM, D. S

“…Responses of cells to cytokines typically involve the activation of a family of latent DNA binding proteins, referred to as signal transducers and activators…”
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Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines by Larner, Andrew C., David, Michael, Feldman, Gerald M., Igarashi, Ken-ichi, Hackett, Rebecca H., Deborah S. A. Webb, Sweitzer, Sharon M., Petricoin, Emanuel F., Finbloom, David S.

“…Interferon-α (IFN-α) and IFN-γ regulate gene expression by tyrosine phosphorylation of several transcription factors that have the 91-kilodalton (p91) protein…”
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Antiproliferative action of interferon-α requires components of T-cell-receptor signalling by Larner, Andrew C, Petricoin, Emanuel F, Ito, Satoshi, Williams, Brandi L, Audet, Susette, Stancato, Louis F, Gamero, Ana, Clouse, Kathleen, Grimley, Philip, Weiss, Arthur, Beeler, Judy, Finbloom, David S, Shores, Elizabeth W, Abraham, Robert

“…Signal transduction through both cytokine and lymphocyte antigen receptors shares some common pathways by which they initiate cellular responses, such as…”
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Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor by IGARASHI, K.-I, GAROTTA, G, OZMEN, L, ZIEMIECKI, A, WILKS, A. F, HARPUR, A. G, LARNER, A. C, FINBLOM, D. S

“…Interferon-gamma (IFN-gamma) induces the expression of a set of early response genes by tyrosine phosphorylation of latent transcription factors such as p91…”
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The Jak Kinases Differentially Associate with the α and β (Accessory Factor) Chains of the Interferon γ Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors by Sakatsume, Minoru, Igarashi, Ken-ichi, Winestock, Karen D., Garotta, Gianni, Larner, Andrew C., Finbloom, David S.

“…Interferon γ (IFNγ) induces the expression of early response genes by tyrosine phosphorylation of Jak kinases and transcription factors referred to as STAT…”
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Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway by Stancato, Louis F., Sakatsume, Minoru, David, Michael, Dent, Paul, Dong, Fan, Petricoin, Emanuel F., Krolewski, John J., Silvennoinen, Olli, Saharinen, Pipsa, Pierce, Jacalyn, Marshall, Christopher J., Sturgill, Thomas, Finbloom, David S., Larner, Andrew C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes by ROSEN, R. L, WINESTOCK, K. D, CHEN, G, LIU, X, HENNIGHAUSEN, L, FINBLOOM, D. S

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces immediate effects in monocytes by activation of the Janus kinase (JAK2) and STAT…”
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Modulation of the expression of the IFN-gamma receptor beta-chain controls responsiveness to IFN-gamma in human peripheral blood T cells by Sakatsume, M, Finbloom, DS

“…IFN-gamma has potent antiproliferative and apoptotic effects in T cells that are important in determining T cell development and polarized differentiation…”
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Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor by MEYER, D. J, CAMPBELL, G. S, COCHRAN, B. H, ARGETSINGER, L. S, LARNER, A. C, FINBLOOM, D. S, CARTER-SU, C, SCHWARTZ, J

“…Signaling mechanisms leading to regulation of gene transcription by growth hormone (GH) and other molecules that signal via the cytokine receptor family have…”
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Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major by Belosevic, M, Finbloom, DS, Van Der Meide, PH, Slayter, MV, Nacy, CA

“…C3H/HeN mice that are naturally resistant to cutaneous disease and systemic infections with the protozoan parasite, Leishmania major, were treated at the time…”
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Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes by Larner, Andrew C., Finbloom, David S.

“…Two well-defined rapid responses which occur as a consequence of growth factors binding to their cell surface receptors involve tyrosine phosphorylation of…”
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Interferon γ Rapidly Induces in Human Monocytes a DNA-Binding Factor that Recognizes the γ Response Region within the Promoter of the Gene for the High-Affinity Fcγ Receptor by Wilson, Kevin C., Finbloom, David S.

“…Interferon γ (IFN-γ) transcriptionally activates several early-response genes in monocytes that are important for the ultimate phenotype of the activated…”
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In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate by IGARASHI, K.-I, DAVID, M, LARNER, A. C, FINBLOOM, D. S

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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IgG immune complexes inhibit IFN-gamma-induced transcription of the Fc gamma RI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 (Stat1) transcription factor by Feldman, GM, Chuang, EJ, Finbloom, DS

“…Immune complexes (IC) modulate Ag-driven immune responses in part by their ability to inhibit IFN-gamma-dependent MHC class II expression. Because many genes,…”
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Prolactin Activates the Interferon-Regulated p91 Transcription Factor and the Jak2 Kinase by Tyrosine Phosphorylation by David, Michael, Petricoin, Emanuel F., Igarashi, Ken-Ichi, Feldman, Gerald M., Finbloom, David S., Larner, Andrew C.

“…The prolactin (PRL) receptor is a member of the family of cytokine receptors that lack intrinsic tyrosine kinase activity but contain two conserved cysteines…”
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Regulation of the Jak/STAT signalling pathway by Finbloom, David S., Larner, Andrew C.

“…Many cytokines, including interferons (IFN), interleukins (IL), and growth factors, induce the transcription of early response genes through the activation of…”
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