Search Results - "Finan, M"

The Divided Bacterial Genome: Structure, Function, and Evolution by diCenzo, George C, Finan, Turlough M

“…Approximately 10% of bacterial genomes are split between two or more large DNA fragments, a genome architecture referred to as a multipartite genome. This…”
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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1 by Dibble, Christian C., Elis, Winfried, Menon, Suchithra, Qin, Wei, Klekota, Justin, Asara, John M., Finan, Peter M., Kwiatkowski, David J., Murphy, Leon O., Manning, Brendan D.

“…The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its…”
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Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts by Helms, Erin J, Berry, Mark W, Chaw, R Crystal, DuFort, Christopher C, Sun, Duanchen, Onate, M Kathrina, Oon, Chet, Bhattacharyya, Sohinee, Sanford-Crane, Hannah, Horton, Wesley, Finan, Jennifer M, Sattler, Ariana, Makar, Rosemary, Dawson, David W, Xia, Zheng, Hingorani, Sunil R, Sherman, Mara H

“…Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood…”
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Reporting Down syndrome on the death certificate for Alzheimer disease/unspecified dementia deaths by Landes, Scott D, Finan, Julia M, Turk, Margaret A

“…Death certificates are crucial for understanding population health trends including the burden of disease mortality. Accurate reporting of causes of death on…”
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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 by Düvel, Katrin, Yecies, Jessica L., Menon, Suchithra, Raman, Pichai, Lipovsky, Alex I., Souza, Amanda L., Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, Vander Heiden, Matthew G., MacKeigan, Jeffrey P., Finan, Peter M., Clish, Clary B., Murphy, Leon O., Manning, Brendan D.

“…Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common molecular event in a variety of pathological settings, including…”
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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy by Nicklin, Paul, Bergman, Philip, Zhang, Bailin, Triantafellow, Ellen, Wang, Henry, Nyfeler, Beat, Yang, Haidi, Hild, Marc, Kung, Charles, Wilson, Christopher, Myer, Vic E., MacKeigan, Jeffrey P., Porter, Jeffrey A., Wang, Y. Karen, Cantley, Lewis C., Finan, Peter M., Murphy, Leon O.

“…Amino acids are required for activation of the mammalian target of rapamycin (mTOR) kinase which regulates protein translation, cell growth, and autophagy…”
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Targeting glutamine metabolism slows soft tissue sarcoma growth by Lee, Pearl, Malik, Dania, Perkons, Nicholas, Huangyang, Peiwei, Khare, Sanika, Rhoades, Seth, Gong, Yao-Yu, Burrows, Michelle, Finan, Jennifer M., Nissim, Itzhak, Gade, Terence P. F., Weljie, Aalim M., Simon, M. Celeste

“…Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of rapid cell growth. However, glutamine dependence can be highly…”
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PhoU Allows Rapid Adaptation to High Phosphate Concentrations by Modulating PstSCAB Transport Rate in Sinorhizobium meliloti by diCenzo, George C, Sharthiya, Harsh, Nanda, Anish, Zamani, Maryam, Finan, Turlough M

“…Maintenance of cellular phosphate homeostasis is essential for cellular life. The PhoU protein has emerged as a key regulator of this process in bacteria, and…”
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Metabolic modelling reveals the specialization of secondary replicons for niche adaptation in Sinorhizobium meliloti by diCenzo, George C., Checcucci, Alice, Bazzicalupo, Marco, Mengoni, Alessio, Viti, Carlo, Dziewit, Lukasz, Finan, Turlough M., Galardini, Marco, Fondi, Marco

“…The genome of about 10% of bacterial species is divided among two or more large chromosome-sized replicons. The contribution of each replicon to the microbial…”
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Robustness encoded across essential and accessory replicons of the ecologically versatile bacterium Sinorhizobium meliloti by diCenzo, George C, Benedict, Alex B, Fondi, Marco, Walker, Graham C, Finan, Turlough M, Mengoni, Alessio, Griffitts, Joel S

“…Bacterial genome evolution is characterized by gains, losses, and rearrangements of functional genetic segments. The extent to which large-scale genomic…”
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MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit by Li, X, Zhang, J, Gao, L, McClellan, S, Finan, M A, Butler, T W, Owen, L B, Piazza, G A, Xi, Yaguang

“…MicroRNAs (miRNAs) have attracted attention because of their key regulatory functions in many biological events, including differentiation and tumorigenesis…”
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BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin by Finan, Gina M., Okada, Hirokazu, Kim, Tae-Wan

“…BACE1 (β-site β-amyloid precursor protein (APP)-cleaving enzyme 1) mediates the first proteolytic cleavage of APP, leading to amyloid β-peptide (Aβ)…”
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Author Correction: Targeting glutamine metabolism slows soft tissue sarcoma growth by Lee, Pearl, Malik, Dania, Perkons, Nicholas, Huangyang, Peiwei, Khare, Sanika, Rhoades, Seth, Gong, Yao-Yu, Burrows, Michelle, Finan, Jennifer M., Nissim, Itzhak, Gade, Terence P. F., Weljie, Aalim M., Simon, M. Celeste

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Factors associated with the reporting of Down syndrome as the underlying cause of death on US death certificates by Landes, S. D., Turk, M. A., Finan, J. M.

“…Background Efforts aimed at preventing premature mortality for people with Down syndrome are hindered by the practice of reporting disability as the underlying…”
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Examination of prokaryotic multipartite genome evolution through experimental genome reduction by diCenzo, George C, MacLean, Allyson M, Milunovic, Branislava, Golding, G Brian, Finan, Turlough M

“…Many bacteria carry two or more chromosome-like replicons. This occurs in pathogens such as Vibrio cholerea and Brucella abortis as well as in many N2-fixing…”
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Genomic resources for identification of the minimal N2-fixing symbiotic genome by diCenzo, George C., Zamani, Maryam, Milunovic, Branislava, Finan, Turlough M.

“…Summary The lack of an appropriate genomic platform has precluded the use of gain‐of‐function approaches to study the rhizobium–legume symbiosis, preventing…”
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De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands by Masalmeh, Roza H. Ali, Taglini, Francesca, Rubio-Ramon, Cristina, Musialik, Kamila I., Higham, Jonathan, Davidson-Smith, Hazel, Kafetzopoulos, Ioannis, Pawlicka, Kamila P., Finan, Hannah M., Clark, Richard, Wills, Jimi, Finch, Andrew J., Murphy, Lee, Sproul, Duncan

“…The aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours and may silence the expression of tumour suppressors such as…”
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The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress by Finan, Jennifer M., Di Niro, Roberto, Park, Soon Young, Jeong, Kang Jin, Hedberg, Madeline D., Smith, Alexander, McCarthy, Grace A., Haber, Alex O., Muschler, John, Sears, Rosalie C., Mills, Gordon B., Gmeiner, William H., Brody, Jonathan R.

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease soon to become the second leading cause of cancer deaths in the US. Beside surgery, current…”
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Heterologous Complementation Reveals a Specialized Activity for BacA in the Medicago-Sinorhizobium meliloti Symbiosis by diCenzo, George C, Zamani, Maryam, Ludwig, Hannah N, Finan, Turlough M

“…The bacterium Sinorhizobium meliloti Rm2011 forms N -fixing root nodules on alfalfa and other leguminous plants. The pSymB chromid contains a 110-kb region…”
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Cell Growth Inhibition upon Deletion of Four Toxin-Antitoxin Loci from the Megaplasmids of Sinorhizobium meliloti by Milunovic, Branislava, diCenzo, George C, Morton, Richard A, Finan, Turlough M

“…Classifications Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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