Search Results - "Filosa, Jessica"

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion by Morrison, Helena W, Filosa, Jessica A

“…Microglia cells continuously survey the healthy brain in a ramified morphology and, in response to injury, undergo progressive morphological and functional…”
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TRPV4 and the Regulation of Vascular Tone by Filosa, Jessica A, Yao, Xiaoqiang, Rath, Geraldine

“…Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4…”
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Potassium Buffering in the Neurovascular Unit: Models and Sensitivity Analysis by Witthoft, Alexandra, Filosa, Jessica A., Karniadakis, George Em

“…Astrocytes are critical regulators of neural and neurovascular network communication. Potassium transport is a central mechanism behind their many functions…”
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Circulating Angiotensin II Gains Access to the Hypothalamus and Brain Stem During Hypertension via Breakdown of the Blood–Brain Barrier by Biancardi, Vinicia Campana, Son, Sook Jin, Ahmadi, Sahra, Filosa, Jessica A., Stern, Javier E.

“…Angiotensin II–mediated vascular brain inflammation emerged as a novel pathophysiological mechanism in neurogenic hypertension. However, the precise underlying…”
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Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks by Son, Sook Jin, Filosa, Jessica A., Potapenko, Evgeniy S., Biancardi, Vinicia C., Zheng, Hong, Patel, Kaushik P., Tobin, Vicky A., Ludwig, Mike, Stern, Javier E.

“…Although communication between neurons is considered a function of the synapse, neurons also release neurotransmitter from their dendrites. We found that…”
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Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice by Morrison, Helena W, Filosa, Jessica A

“…Highlights • Astrocyte Ca2+ dynamics are different in male and female mice after ischemia. • Sex differences in astrocyte AQP4 polarity and non-somatic S100β…”
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Stroke and the neurovascular unit: glial cells, sex differences, and hypertension by Morrison, Helena W, Filosa, Jessica A

“…A functional neurovascular unit (NVU) is central to meeting the brain's dynamic metabolic needs. Poststroke damage to the NVU within the ipsilateral hemisphere…”
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Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension by Presa, Jessica L, Saravia, Flavia, Bagi, Zsolt, Filosa, Jessica A

“…Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe…”
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Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis by Huby, Anne-Cécile, Antonova, Galina, Groenendyk, Jake, Gomez-Sanchez, Celso E, Bollag, Wendy B, Filosa, Jessica A, de Chantemèle, Eric J Belin

“…BACKGROUND—In obesity, the excessive synthesis of aldosterone contributes to the development and progression of metabolic and cardiovascular dysfunctions…”
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Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons by Kim, Ki Jung, Ramiro Diaz, Juan, Iddings, Jennifer A, Filosa, Jessica A

“…Continuous cerebral blood flow is essential for neuronal survival, but whether vascular tone influences resting neuronal function is not known. Using a…”
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Astrocyte regulation of cerebral vascular tone by Filosa, Jessica A, Iddings, Jennifer A

“…Cerebral blood flow is controlled by two crucial processes, cerebral autoregulation (CA) and neurovascular coupling (NVC) or functional hyperemia. Whereas CA…”
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Upstream current for a downstream flow by Filosa, Jessica A

“…Capillary endothelial cells sense neuronal activity-evoked increases in extracellular K + via K IR 2.1 inwardly rectifying K + channels. The ensuing…”
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Guidelines for the measurement of vascular function and structure in isolated arteries and veins by Wenceslau, Camilla F, McCarthy, Cameron G, Earley, Scott, England, Sarah K, Filosa, Jessica A, Goulopoulou, Styliani, Gutterman, David D, Isakson, Brant E, Kanagy, Nancy L, Martinez-Lemus, Luis A, Sonkusare, Swapnil K, Thakore, Pratish, Trask, Aaron J, Watts, Stephanie W, Webb, R Clinton

“…The measurement of vascular function in isolated vessels has revealed important insights into the structural, functional, and biomechanical features of the…”
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Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction by Kim, Ki Jung, Iddings, Jennifer A, Stern, Javier E, Blanco, Víctor M, Croom, Deborah, Kirov, Sergei A, Filosa, Jessica A

“…Basal and activity-dependent cerebral blood flow changes are coordinated by the action of critical processes, including cerebral autoregulation,…”
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Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation by Kim, Ki Jung, Filosa, Jessica A.

“…Key points  •  We show that parenchymal arterioles of less than 30 μm in diameter can be successfully cannulated and perfused in cortical and hypothalamic…”
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Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II‐infused hypertensive mice by Diaz, Juan Ramiro, Kim, Ki Jung, Brands, Michael W., Filosa, Jessica A.

“…Hypertension is an important contributor to cognitive decline but the underlying mechanisms are unknown. Although much focus has been placed on the effect of…”
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Neurovascular coupling and CO2 interrogate distinct vascular regulations by Tournissac, Marine, Chaigneau, Emmanuelle, Pfister, Sonia, Aydin, Ali-Kemal, Goulam Houssen, Yannick, O’Herron, Philip, Filosa, Jessica, Collot, Mayeul, Joutel, Anne, Charpak, Serge

“…Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in response to neuronal activation, is commonly used to map brain…”
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Neuronal-derived nitric oxide and somatodendritically released vasopressin regulate neurovascular coupling in the rat hypothalamic supraoptic nucleus by Du, Wenting, Stern, Javier E, Filosa, Jessica A

“…The classical model of neurovascular coupling (NVC) implies that activity-dependent axonal glutamate release at synapses evokes the production and release of…”
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Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge by Roy, Ranjan K., Althammer, Ferdinand, Seymour, Alexander J., Du, Wenting, Biancardi, Vinicia C., Hamm, Jordan P., Filosa, Jessica A., Brown, Colin H., Stern, Javier E.

“…Neurovascular coupling (NVC), the process that links neuronal activity to cerebral blood flow changes, has been mainly studied in superficial brain areas,…”
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Local potassium signaling couples neuronal activity to vasodilation in the brain by Nelson, Mark T, Filosa, Jessica A, Bonev, Adrian D, Straub, Stephen V, Meredith, Andrea L, Wilkerson, M Keith, Aldrich, Richard W

“…The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral arterioles to dilate remain obscure. Here we show that modest elevation of…”
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