Search Results - "Filkins, Robert J"
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Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue
Published in Proceedings of the National Academy of Sciences - PNAS (16-07-2013)“…Limitations on the number of unique protein and DNA molecules that can be characterized microscopically in a single tissue specimen impede advances in…”
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Journal Article -
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Simple and robust image-based autofocusing for digital microscopy
Published in Optics express (09-06-2008)“…A simple image-based autofocusing scheme for digital microscopy is demonstrated that uses as few as two intermediate images to bring the sample into focus. The…”
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Journal Article -
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A novel, automated technology for multiplex biomarker imaging and application to breast cancer
Published in Histopathology (01-01-2014)“…Aims Multiplexed immunofluorescence is a powerful tool for validating multigene assays and understanding the complex interplay of proteins implicated in breast…”
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Journal Article -
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Autofocus methods of whole slide imaging systems and the introduction of a second-generation independent dual sensor scanning method
Published in Journal of pathology informatics (2011)“…Accurate focusing is a critical challenge of whole slide imaging, primarily due to inherent tissue topography variability. Traditional line scanning and…”
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Journal Article -
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Ki-67 Membranous Staining: Biologically Relevant or an Artifact of Multiplexed Immunofluorescent Staining
Published in Applied immunohistochemistry & molecular morphology (01-07-2016)“…In the process of developing a multiplex of 8 common breast cancer biomarkers (Her2/neu, estrogen receptor, progesterone receptor, Ki-67, aldehyde…”
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Journal Article -
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Experimental comparison between optical spectroscopy and laser-ultrasound generation in polymer-matrix composites
Published in Applied physics letters (17-09-2001)“…Laser ultrasound is a technique based on lasers to generate and detect ultrasound. The generation mechanism involves several parameters among which one of the…”
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Journal Article -
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Intraoperative Near-Infrared Fluorescence Imaging
Published in 2007 Conference on Lasers and Electro-Optics (CLEO) (01-05-2007)“…We have developed a low-cost, safe, and easy to use NIR fluorescence intraoperative imaging system that permits the surgeon to see, in real time, surgical…”
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Conference Proceeding -
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Intraoperative near-infrared fluorescence imaging
Published in 2007 Quantum Electronics and Laser Science Conference (01-05-2007)“…We have developed a low-cost, safe, and easy to use NIR fluorescence intraoperative imaging system that permits the surgeon to see, in real time, surgical…”
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Conference Proceeding -
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Recent advances in all-optical acousto-optic devices
Published in 1998 IEEE Ultrasonics Symposium. Proceedings (Cat. No. 98CH36102) (1998)“…Conventional acousto-optic devices employ an RF electrical signal applied to a piezoelectric transducer to generate ultrasound. Recent work has been toward…”
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Conference Proceeding