Search Results - "Filiz ONAT"

Astrocytes as a target for therapeutic strategies in epilepsy: current insights by Çarçak, Nihan, Onat, Filiz, Sitnikova, Evgenia

“…Astrocytes are specialized non-neuronal glial cells of the central nervous system, contributing to neuronal excitability and synaptic transmission…”
Get full text

Editorial: Epileptic seizure disorders in animal models: advances in translational approaches by Sitnikova, Evgenia, Onat, Filiz, van Luijtelaar, Gilles

Get full text

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats by Alpay, Berkay, Cimen, Bariscan, Akaydin, Elif, Onat, Filiz, Bolay, Hayrunnisa, Sara, Yildirim

“…Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over…”
Get full text

The effect of serum levetiracetam concentrations on therapeutic response and IL1-beta concentration in patients with epilepsy by Gulcebi, Medine I., Kendirli, Tansel, Turgan, Zehra Asik, Patsalos, Philip N., Yilmaz Onat, Filiz

“…•Maximum serum concentration (Cmax) of levetiracetam may be a better indicator of therapeutic response and for development of adverse effects.•Consequently,…”
Get full text

WONOEP appraisal: Biomarkers of epilepsy‐associated comorbidities by Ravizza, Teresa, Onat, Filiz Y., Brooks‐Kayal, Amy R., Depaulis, Antoine, Galanopoulou, Aristea S., Mazarati, Andrey, Numis, Adam L., Sankar, Raman, Friedman, Alon

“…Summary Neurologic and psychiatric comorbidities are common in patients with epilepsy. Diagnostic, predictive, and pharmacodynamic biomarkers of such…”
Get full text

Alpha‐2a adrenergic receptor activation in genetic absence epilepsy: An absence status model? by Yavuz, Melis, Akkol, Serdar, Onat, Filiz

“…Objective The objective of the study was to propose a candidate animal model of absence status epilepticus induced by specific alpha‐2a adrenergic receptor…”
Get full text

The involvement of limbic structures in typical and atypical absence epilepsy by Onat, Filiz Yılmaz, van Luijtelaar, Gilles, Nehlig, Astrid, Snead, O. Carter

“…Summary Typical and atypical seizures of absence epilepsy are thought to be generated by a rhythmogenic interplay between the cortex and the thalamus. However,…”
Get full text

Antibody induced seizure susceptibility and impaired cognitive performance in a passive transfer rat model of autoimmune encephalitis by Pişkin, Şura Akat, Korkmaz, Hande Yüceer, Ulusoy, Canan Aysel, Şanlı, Elif, Küçükali, Cem Ismail, Onat, Filiz, Tüzün, Erdem, Çarçak, Nihan

“…Autoimmune encephalitis (AE) is a distinct neuro-immunological disorder associated with the production of autoantibodies against neuronal proteins responsible…”
Get full text

Dexmedetomidine, an alpha 2A receptor agonist, triggers seizures unilaterally in GAERS during the pre-epileptic phase: does the onset of spike-and-wave discharges occur in a focal manner? by Yavuz, Melis, İyiköşker, Pelin, Mutlu, Nursima, Kiliçparlar, Serra, Şalci, Öykü Hazal, Dolu, Gökçen, Kaymakçilar, Elif Nur, Akkol, Serdar, Onat, Filiz

“…The genetic absence epilepsy rat from Strasbourg (GAERS) is a rat model for infantile absence epilepsy with spike-and-wave discharges (SWDs). This study aimed…”
Get full text

Neurogenesis is Enhanced in Young Rats with Genetic Absence Epilepsy: An Immuno-electron Microscopic Study by Cilingir-Kaya, Ozlem Tugce, Moore, Cynthia, Meshul, Charles Kenneth, Gursoy, Duygu, Filiz, Onat, Sirvanci, Serap

“…Neurogenesis is an age-related process that is closely associated with neurological disorders. In the present study, we aimed to investigate neurogenesis in…”
Get full text

Effect of U-92032, T-Type Ca2+ Channel Blocker, on Rats with Genetic Absence Epilepsy by Yananli, Hasan Raci, Demirkapu, Mahluga Jafarova, Sakallı, Halil Eren, Gülhan, Rezzan, Onat, Filiz Yılmaz

“…Absence epilepsy is associated with diffuse spike-and-wave discharges (SWD) on the electroencephalogram (EEG). Recent studies have demonstrated that the…”
Get more information

Involvement of orexin type-2 receptors in genetic absence epilepsy rats by Toplu, Aylin, Mutlu, Nursima, Erdeve, Elif Tuğçe, Sariyildiz, Özge, Çelik, Musa, Öz-Arslan, Devrim, Akman, Özlem, Molnár, Zoltan, Çarçak, Nihan, Onat, Filiz

“…Orexin is a neuropeptide neurotransmitter that regulates the sleep/wake cycle produced by the lateral hypothalamus neurons. Recent studies have shown the…”
Get full text

Effects of swimming training on orexin receptor 2 distribution in brain damage of rats by Akakın, Dilek, Elmas, Merve Acikel, Koroglu, Ayca Karagoz, Ozakpinar, Ozlem Bingol, Onat, Filiz, Ercan, Feriha

Get full text

The Role of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Pathophysiology of Absence Epilepsy by Melis YAVUZ, Filiz ONAT

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels participate in pacemaker currents, modulating the funny current (I[f]) in cardiac cells and…”
Get full text

Impact of Valproate and Levetiracetam Exposure on GAERS Behavior During Pregnancy by Yavuz, Melis, Kantarcı, Berk Can, Şanlı, Ahmet, Gavaş, Şeyhmus, Turgan Aşık, Zehra Nur, Koyuncuoğlu, Türkan, Kasımay, Özgür, Onat, Filiz

“…Objective:Valproate (VPA) and levetiracetam (LEV) are frequently prescribed for the management of idiopathic generalized seizures; however, their…”
Get full text

Animal models of absence epilepsies: What do they model and do sex and sex hormones matter? by van Luijtelaar, Gilles, Onat, Filiz Yilmaz, Gallagher, Martin J

“…Abstract While epidemiological data suggest a female prevalence in human childhood- and adolescence-onset typical absence epilepsy syndromes, the sex…”
Get full text

The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy by Akman, Ozlem, Gulcebi, Medine I., Carcak, Nihan, Ketenci Ozatman, Sema, Eryigit, Tugba, Moshé, Solomon L., Galanopoulou, Aristea S., Onat, Filiz Yilmaz

“…Summary Objective Genetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by…”
Get full text

Resistance to Propagation of Amygdaloid Kindling Seizures in Rats with Genetic Absence Epilepsy by Eşkazan, Esat, Onat, Filiz Yõlmaz, Aker, Rezzan, Öner, Gülay

“…Purpose: The existence of absence epilepsy and temporal partial seizure pattern in the same patient is an uncommon state. In the present study, we aimed to…”
Get full text

The pathways connecting the hippocampal formation, the thalamic reuniens nucleus and the thalamic reticular nucleus in the rat by Çavdar, Safiye, Onat, Filiz Y., Çakmak, Yusuf Özgür, Yananli, Hasan R., Gülçebi, Medine, Aker, Rezzan

“…Most dorsal thalamic nuclei send axons to specific areas of the neocortex and to specific sectors of the thalamic reticular nucleus; the neocortex then sends…”
Get full text

Topographical connections of the substantia nigra pars reticulata to higher-order thalamic nuclei in the rat by Gulcebi, Medine Idrizoglu, Ketenci, Sema, Linke, Rudiger, Hacıoğlu, Husniye, Yanalı, Hasan, Veliskova, Jana, Moshé, Solomon L, Onat, Filiz, Çavdar, Safiye

“…Highlights ► The higher-order thalamic relays receive modulatory GABAergic inputs from the substantia nigra pars reticulata (SNR). ► These inputs are…”
Get full text