Search Results - "Filipe, Elysse"
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Charting the unexplored extracellular matrix in cancer
Published in International journal of experimental pathology (01-04-2018)“…Summary The extracellular matrix (ECM) is present in all solid tissues and considered a master regulator of cell behaviour and phenotype. The importance of…”
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2
Bovine and human endometrium-derived hydrogels support organoid culture from healthy and cancerous tissues
Published in Proceedings of the National Academy of Sciences - PNAS (01-11-2022)“…Organoid technology has provided unique insights into human organ development, function, and diseases. Patient-derived organoids are increasingly used for drug…”
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3
Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts
Published in Scientific reports (25-11-2019)“…Current synthetic vascular grafts are not suitable for use in low-diameter applications. Silk fibroin is a promising natural graft material which may be an…”
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Rapid Endothelialization of Off-the-Shelf Small Diameter Silk Vascular Grafts
Published in JACC. Basic to translational science (01-02-2018)“…Visual Abstract Electrospinning of silk to create nanofibers, which deposit onto a rotating collector. This results in the formation of a pure silk conduit of…”
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Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo
Published in Scientific reports (30-07-2020)“…Multifunctional nanocarriers (MNCs) promise to improve therapeutic outcomes by combining multiple classes of molecules into a single nanostructure, enhancing…”
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Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing
Published in Stem cell research & therapy (09-05-2015)“…The secretion of trophic factors by mesenchymal stromal cells has gained increased interest given the benefits it may bring to the treatment of a variety of…”
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Mechanically Robust Plasma-Activated Interfaces Optimized for Vascular Stent Applications
Published in ACS applied materials & interfaces (20-04-2016)“…The long-term performance of many medical implants is limited by the use of inherently incompatible and bioinert materials. Metallic alloys, ceramics, and…”
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Recent advances in understanding the complexities of metastasis [version 2; peer review: 3 approved]
Published in F1000 research (2018)“…Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-autonomous program but as a multifaceted and complex series of…”
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Bioactive Materials Facilitating Targeted Local Modulation of Inflammation
Published in JACC. Basic to translational science (01-02-2019)“…Visual Abstract…”
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10
Characterization of Endothelial Progenitor Cell Interactions with Human Tropoelastin
Published in PloS one (26-06-2015)“…The deployment of endovascular implants such as stents in the treatment of cardiovascular disease damages the vascular endothelium, increasing the risk of…”
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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
Published in Nature cancer (01-09-2023)“…The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance of this family in crosslinking and…”
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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis
Published in Nature communications (06-08-2022)“…The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their…”
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Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism
Published in Advanced science (01-06-2024)“…In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary…”
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The Human Umbilical Cord Tissue-Derived MSC Population UCX(®) Promotes Early Motogenic Effects on Keratinocytes and Fibroblasts and G-CSF-Mediated Mobilization of BM-MSCs When Transplanted In Vivo
Published in Cell transplantation (01-05-2015)“…Mesenchymal stromal cells (MSCs) play an important role in tissue regeneration mainly through the secretion of trophic factors that enhance the repair of…”
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Plasma mediated protein immobilisation enhances the vascular compatibility of polyurethane with tissue matched mechanical properties
Published in Biomedical materials (Bristol) (04-07-2017)“…Polyurethanes are a diverse class of polymers, with independently tunable mechanical and biodegradation properties making them a versatile platform material…”
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Recent advances in understanding the complexities of metastasis
Published in F1000 research (2018)“…Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-autonomous program but as a multifaceted and complex series of…”
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17
Plasma Synthesis of Carbon-Based Nanocarriers for Linker-Free Immobilization of Bioactive Cargo
Published in ACS applied nano materials (23-02-2018)“…Multifunctional nanoparticles are increasingly employed to improve biological efficiency in medical imaging, diagnostics, and treatment applications. However,…”
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Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response
Published in Science advances (05-07-2024)“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased…”
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The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development
Published in Cancer reports (01-02-2020)“…Background The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response of cells to interventions in normal…”
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TCT-433 Plasmin Immobilization for Reduced Thrombogenicity of Metallic Implants
Published in Journal of the American College of Cardiology (16-09-2014)“…Strikingly, the 10U plasmin surface significantly reduced clot weight 97.7±1.3% in a modified chandler loop, relative to SS and PAC alone (p< 0.001)…”
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