Search Results - "Filip, Lardon"

The potential and controversy of targeting STAT family members in cancer by Verhoeven, Yannick, Tilborghs, Sam, Jacobs, Julie, De Waele, Jorrit, Quatannens, Delphine, Deben, Christophe, Prenen, Hans, Pauwels, Patrick, Trinh, Xuan Bich, Wouters, An, Smits, Evelien L.J., Lardon, Filip, van Dam, Peter A.

“…The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the…”
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Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays by Limame, Ridha, Wouters, An, Pauwels, Bea, Fransen, Erik, Peeters, Marc, Lardon, Filip, De Wever, Olivier, Pauwels, Patrick

“…Cell viability and motility comprise ubiquitous mechanisms involved in a variety of (patho)biological processes including cancer. We report a technical…”
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The CD70-CD27 axis in oncology: the new kids on the block by Flieswasser, Tal, Van den Eynde, Astrid, Van Audenaerde, Jonas, De Waele, Jorrit, Lardon, Filip, Riether, Carsten, de Haard, Hans, Smits, Evelien, Pauwels, Patrick, Jacobs, Julie

“…The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27…”
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Cellular senescence in cancer: clinical detection and prognostic implications by Domen, Andreas, Deben, Christophe, Verswyvel, Jasper, Flieswasser, Tal, Prenen, Hans, Peeters, Marc, Lardon, Filip, Wouters, An

“…Cellular senescence is a state of stable cell-cycle arrest with secretory features in response to cellular stress. Historically, it has been considered as an…”
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The Right Partner in Crime: Unlocking the Potential of the Anti-EGFR Antibody Cetuximab via Combination With Natural Killer Cell Chartering Immunotherapeutic Strategies by Baysal, Hasan, De Pauw, Ines, Zaryouh, Hannah, Peeters, Marc, Vermorken, Jan Baptist, Lardon, Filip, De Waele, Jorrit, Wouters, An

“…Cetuximab has an established role in the treatment of patients with recurrent/metastatic colorectal cancer and head and neck squamous cell cancer (HNSCC)…”
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A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy by De Waele, Jorrit, Verhezen, Tias, van der Heijden, Sanne, Berneman, Zwi N, Peeters, Marc, Lardon, Filip, Wouters, An, Smits, Evelien L. J. M

“…Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological…”
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Cetuximab-induced natural killer cell cytotoxicity in head and neck squamous cell carcinoma cell lines: investigation of the role of cetuximab sensitivity and HPV status by Baysal, Hasan, De Pauw, Ines, Zaryouh, Hannah, De Waele, Jorrit, Peeters, Marc, Pauwels, Patrick, Vermorken, Jan Baptist, Smits, Evelien, Lardon, Filip, Jacobs, Julie, Wouters, An

“…Background The epidermal growth factor receptor (EGFR) is overexpressed by 80–90% of squamous cell carcinoma of head and neck (HNSCC). In addition to…”
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A Review of the Most Promising Biomarkers in Colorectal Cancer: One Step Closer to Targeted Therapy by Deschoolmeester, Vanessa, Baay, Marc, Specenier, Pol, Lardon, Filip, Vermorken, Jan B.

“…Rapidly growing insights into the molecular biology of colorectal cancer (CRC) and recent developments in gene sequencing and molecular diagnostics have led to…”
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Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells by Van Loenhout, Jinthe, Flieswasser, Tal, Freire Boullosa, Laurie, De Waele, Jorrit, Van Audenaerde, Jonas, Marcq, Elly, Jacobs, Julie, Lin, Abraham, Lion, Eva, Dewitte, Heleen, Peeters, Marc, Dewilde, Sylvia, Lardon, Filip, Bogaerts, Annemie, Deben, Christophe, Smits, Evelien

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a low response to treatment and a five-year survival rate below 5%. The…”
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Cancer-Associated Fibroblasts as a Common Orchestrator of Therapy Resistance in Lung and Pancreatic Cancer by Domen, Andreas, Quatannens, Delphine, Zanivan, Sara, Deben, Christophe, Van Audenaerde, Jonas, Smits, Evelien, Wouters, An, Lardon, Filip, Roeyen, Geert, Verhoeven, Yannick, Janssens, Annelies, Vandamme, Timon, van Dam, Peter, Peeters, Marc, Prenen, Hans

“…Cancer arises from mutations accruing within cancer cells, but the tumor microenvironment (TME) is believed to be a major, often neglected, factor involved in…”
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Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients by Deschoolmeester, Vanessa, Baay, Marc, Van Marck, Eric, Weyler, Joost, Vermeulen, Peter, Lardon, Filip, Vermorken, Jan B

“…There is growing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of solid tumors…”
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Immune Checkpoint Modulation in Colorectal Cancer: What’s New and What to Expect by Pauwels, Patrick, Lardon, Filip, Smits, Evelien, Jacobs, Julie, Deschoolmeester, Vanessa

“…Colorectal cancer (CRC), as one of the most prevalent types of cancer worldwide, is still a leading cause of cancer related mortality. There is an urgent need…”
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Anti‐Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance by Boeckx, Carolien, Baay, Marc, Wouters, An, Specenier, Pol, Vermorken, Jan B., Peeters, Marc, Lardon, Filip

“…Targeted therapy against the epidermal growth factor receptor (EGFR) is one of the most promising molecular therapeutics for head and neck squamous cell…”
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The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy by Zaryouh, Hannah, De Pauw, Ines, Baysal, Hasan, Pauwels, Patrick, Peeters, Marc, Vermorken, Jan Baptist, Lardon, Filip, Wouters, An

“…The epidermal growth factor receptor (EGFR) is a therapeutic target in head and neck squamous cell carcinoma (HNSCC). Resistance to EGFR-targeted therapies,…”
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OrBITS: label-free and time-lapse monitoring of patient derived organoids for advanced drug screening by Deben, Christophe, De La Hoz, Edgar Cardenas, Compte, Maxim Le, Van Schil, Paul, Hendriks, Jeroen M.H., Lauwers, Patrick, Yogeswaran, Suresh Krishan, Lardon, Filip, Pauwels, Patrick, Van Laere, Steven, Bogaerts, Annemie, Smits, Evelien, Vanlanduit, Steve, Lin, Abraham

“…Background Patient-derived organoids are invaluable for fundamental and translational cancer research and holds great promise for personalized medicine…”
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Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma by Van Loenhout, Jinthe, Freire Boullosa, Laurie, Quatannens, Delphine, De Waele, Jorrit, Merlin, Céline, Lambrechts, Hilde, Lau, Ho Wa, Hermans, Christophe, Lin, Abraham, Lardon, Filip, Peeters, Marc, Bogaerts, Annemie, Smits, Evelien, Deben, Christophe

“…Targeting the redox balance of malignant cells via the delivery of high oxidative stress unlocks a potential therapeutic strategy against glioblastoma (GBM)…”
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Targeting CD70 in combination with chemotherapy to enhance the anti-tumor immune effects in non-small cell lung cancer by Flieswasser, Tal, Van den Eynde, Astrid, Freire Boullosa, Laurie, Melis, Jöran, Hermans, Christophe, Merlin, Céline, Lau, Ho Wa, Van Audenaerde, Jonas, Lardon, Filip, Smits, Evelien, Pauwels, Patrick, Jacobs, Julie

“…Despite the recent emergence of immune checkpoint inhibitors, clinical outcomes of metastatic NSCLC patients remain poor, pointing out the unmet need to…”
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The prognostic impact of the immune signature in head and neck squamous cell carcinoma by Baysal, Hasan, Siozopoulou, Vasiliki, Zaryouh, Hannah, Hermans, Christophe, Lau, Ho Wa, Lambrechts, Hilde, Fransen, Erik, De Pauw, Ines, Jacobs, Julie, Peeters, Marc, Pauwels, Patrick, Vermorken, Jan Baptist, Smits, Evelien, Lardon, Filip, De Waele, Jorrit, Wouters, An

“…Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that retain their poor prognosis despite recent advances in their standard of…”
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Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells by Szarc vel Szic, Katarzyna, Op de Beeck, Ken, Ratman, Dariusz, Wouters, An, Beck, Ilse M, Declerck, Ken, Heyninck, Karen, Fransen, Erik, Bracke, Marc, De Bosscher, Karolien, Lardon, Filip, Van Camp, Guy, Vanden Berghe, Wim

“…Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical…”
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Targeting the PD-1 Axis with Pembrolizumab for Recurrent or Metastatic Cancer of the Uterine Cervix: A Brief Update by Verhoeven, Yannick, Quatannens, Delphine, Trinh, Xuan Bich, Wouters, An, Smits, Evelien L J, Lardon, Filip, De Waele, Jorrit, van Dam, Peter A

“…Even though cervical cancer is partly preventable, it still poses a great public health problem throughout the world. Current therapies have vastly improved…”
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