Search Results - "Filiano, J."

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia by Cronk, James C, Filiano, Anthony J, Louveau, Antoine, Marin, Ioana, Marsh, Rachel, Ji, Emily, Goldman, Dylan H, Smirnov, Igor, Geraci, Nicholas, Acton, Scott, Overall, Christopher C, Kipnis, Jonathan

“…Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and during central nervous system (CNS) inflammation. It was initially…”
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Interactions of innate and adaptive immunity in brain development and function by Filiano, Anthony J, Gadani, Sachin P, Kipnis, Jonathan

“…Abstract It has been known for decades that the immune system has a tremendous impact on behavior. Most work has described the negative role of immune cells on…”
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Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury by Norris, Geoffrey T, Smirnov, Igor, Filiano, Anthony J, Shadowen, Hannah M, Cody, Kris R, Thompson, Jeremy A, Harris, Tajie H, Gaultier, Alban, Overall, Christopher C, Kipnis, Jonathan

“…Phagocytosis of synaptic material by microglia is critical for central nervous system development. Less well understood is this microglial function in the…”
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ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects by Qiu, Haiyan, Lee, Sebum, Shang, Yulei, Wang, Wen-Yuan, Au, Kin Fai, Kamiya, Sherry, Barmada, Sami J, Finkbeiner, Steven, Lui, Hansen, Carlton, Caitlin E, Tang, Amy A, Oldham, Michael C, Wang, Hejia, Shorter, James, Filiano, Anthony J, Roberson, Erik D, Tourtellotte, Warren G, Chen, Bin, Tsai, Li-Huei, Huang, Eric J

“…Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial amyotrophic lateral sclerosis (FALS); however, it is not clear how FUS…”
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Meningeal whole mount preparation and characterization of neural cells by flow cytometry by Louveau, Antoine, Filiano, Anthony J, Kipnis, Jonathan

“…Neuroimmunologists aim to understand the interactions between the central nervous system and the immune system under both homeostatic and pathological…”
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Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications by Saha, Arjun, Patel, Sachit, Xu, Li, Scotland, Paula, Schwartzman, Jonathan, Filiano, Anthony J, Kurtzberg, Joanne, Balber, Andrew E

“…Cord blood (CB) mononuclear cells (MNC) are being tested in clinical trials to treat hypoxic-ischemic (HI) brain injuries. Although early results are…”
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Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice by Filiano, Anthony J, Martens, Lauren Herl, Young, Allen H, Warmus, Brian A, Zhou, Ping, Diaz-Ramirez, Grisell, Jiao, Jian, Zhang, Zhijun, Huang, Eric J, Gao, Fen-Biao, Farese, Jr, Robert V, Roberson, Erik D

“…Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in social and emotional function. Heterozygous loss-of-function mutations…”
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Breaking bad blood: β2-microglobulin as a pro-aging factor in blood by Filiano, Anthony J, Kipnis, Jonathan

“…Aging is a major risk factor for cognitive decline and neurodegenerative diseases. A new study identified β2-microglobulin as a blood-borne factor that…”
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Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons by Rintoul, Gordon L, Filiano, Anthony J, Brocard, Jacques B, Kress, Geraldine J, Reynolds, Ian J

“…Mitochondria are essential to maintain neuronal viability. In addition to the generation of ATP and maintenance of calcium homeostasis, the effective delivery…”
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Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD by Ward, Michael E, Taubes, Alice, Chen, Robert, Miller, Bruce L, Sephton, Chantelle F, Gelfand, Jeffrey M, Minami, Sakura, Boscardin, John, Martens, Lauren Herl, Seeley, William W, Yu, Gang, Herz, Joachim, Filiano, Anthony J, Arrant, Andrew E, Roberson, Erik D, Kraft, Timothy W, Farese, Jr, Robert V, Green, Ari, Gan, Li

“…Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR…”
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Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice by Arrant, Andrew E., Filiano, Anthony J., Patel, Aashka R., Hoffmann, Madelyn Q., Boyle, Nicholas R., Kashyap, Shreya N., Onyilo, Vincent C., Young, Allen H., Roberson, Erik D.

“…Loss-of-function mutations in progranulin (GRN), most of which cause progranulin haploinsufficiency, are a major autosomal dominant cause of frontotemporal…”
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Medullary Serotonergic Network Deficiency in the Sudden Infant Death Syndrome: Review of a 15-Year Study of a Single Dataset by KINNEY, HANNAH C, FILIANO, JAMES J, WHITE, W F

“…The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, despite a dramatic 38% decrease in…”
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Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test by Arrant, A. E., Filiano, A. J., Warmus, B. A., Hall, A. M., Roberson, E. D.

“…Loss‐of‐function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia (FTD), a neurodegenerative disorder in which…”
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How and why do T cells and their derived cytokines affect the injured and healthy brain? by Filiano, Anthony J., Gadani, Sachin P., Kipnis, Jonathan

“…Recent evidence suggests that T cells and their derived cytokines affect the brain in disease and health. In this Opinion article, Kipnis and colleagues…”
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Improving thymus implantation for congenital athymia with interleukin‐7 by Min, Hyunjung, Valente, Laura A, Xu, Li, O'Neil, Shane M, Begg, Lauren R, Kurtzberg, Joanne, Filiano, Anthony J

“…Objectives Thymus implantation is a recently FDA‐approved therapy for congenital athymia. Patients receiving thymus implantation develop a functional but…”
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An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue–derived MSCs for research purposes by Viswanathan, Sowmya, Blanc, Katarina Le, Ciccocioppo, Rachele, Dagher, Georges, Filiano, Anthony J., Galipeau, Jacques, Krampera, Mauro, Krieger, Lena, Lalu, Manoj M., Nolta, Jan, Rodriguez Pardo, Viviana Marcela, Shi, Yufang, Tarte, Karin, Weiss, Daniel J., Martin, Ivan

“…The rapidly growing field of mesenchymal stromal cell (MSC) basic and translational research requires standardization of terminology and functional…”
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Risk of epilepsy in rheumatoid arthritis: a meta-analysis of population based studies and bioinformatics analysis by Zhao, Huawei, Li, Shan, Xie, Meijuan, Chen, Rongrong, Lu, Haimei, Wen, Chengping, Filiano, Anthony J., Xu, Zhenghao

“…Background: An increasing number of studies support an association between rheumatoid arthritis (RA) and brain disorders. This study aims to determine the…”
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Neuroimmunology in 2017: The central nervous system: privileged by immune connections by Kipnis, Jonathan, Filiano, Anthony J

“…Over the past few years, interest in the field of neuroimmunology has expanded dramatically, thanks largely to new technologies that have advanced our…”
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Unique aspects of IFN‐γ/STAT1 signaling in neurons by Clark, Danielle N., Begg, Lauren R., Filiano, Anthony J.

“…The IFN‐γ/STAT1 immune signaling pathway impacts many homeostatic and pathological aspects of neurons, beyond its canonical role in controlling intracellular…”
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Hypothermic Reperfusion After Cardiac Arrest Augments Brain-Derived Neurotrophic Factor Activation by D'Cruz, Brian J., Fertig, Kristofer C., Filiano, Anthony J., Hicks, Shawn D., DeFranco, Donald B., Callaway, Clifton W.

“…Induction of mild hypothermia improves neurologic outcome after global cerebral ischemia. This study measured levels of brain-derived neurotrophic factor…”
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