Search Results - "Fili, Natalia"
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Myosin VI regulates the spatial organisation of mammalian transcription initiation
Published in Nature communications (15-03-2022)“…During transcription, RNA Polymerase II (RNAPII) is spatially organised within the nucleus into clusters that correlate with transcription activity. While this…”
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2
NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
Published in Nature communications (30-11-2017)“…Myosin VI (MVI) has been found to be overexpressed in ovarian, breast and prostate cancers. Moreover, it has been shown to play a role in regulating cell…”
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Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function
Published in The Journal of biological chemistry (10-01-2020)“…Myosin VI is involved in many cellular processes ranging from endocytosis to transcription. This multifunctional potential is achieved through alternative…”
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4
Atomic Force Microscopy micro-rheology reveals large structural inhomogeneities in single cell-nuclei
Published in Scientific reports (14-08-2017)“…During growth, differentiation and migration of cells, the nucleus changes size and shape, while encountering forces generated by the cell itself and its…”
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Definition, aims, and implementation of GA 2 LEN/HAEi Angioedema Centers of Reference and Excellence
Published in Allergy (Copenhagen) (01-08-2020)Get full text
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Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD
Published in Nucleic acids research (01-05-2013)“…The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity…”
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COVID-19 triggers attacks in HAE patients without worsening disease outcome
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01-03-2022)“…Clinical Implications We observed that acute respiratory syndrome coronavirus 2 infection can trigger attacks in hereditary angioedema with or without C1…”
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A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9
Published in Biomolecules (Basel, Switzerland) (15-02-2021)“…Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular…”
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Unconventional Myosins: How Regulation Meets Function
Published in International journal of molecular sciences (20-12-2019)“…Unconventional myosins are multi-potent molecular motors that are assigned important roles in fundamental cellular processes. Depending on their…”
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10
Consenso argentino de diagnóstico y tratamiento del angioedema hereditario
Published in Revista alergia Mexico (Tecamachalco, Pueblo, Mexico : 1993) (09-08-2021)“…Objetivos: El angioedema hereditario es una enfermedad poco frecuente. Durante los últimos años se han desarrollado muchas investigaciones y registrado avances…”
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11
Novel Tales About the Myosin VI Tail
Published in Biophysical journal (15-02-2019)Get full text
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12
High-throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays
Published in Biophysical journal (16-02-2021)“…Mechanobiology is focused on how the physical forces and mechanical properties of proteins, cells, and tissues contribute to physiology and disease. Although…”
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Binding partners regulate unfolding of myosin VI to activate the molecular motor
Published in Biochemical journal (15-07-2022)“…Myosin VI is the only minus-end actin motor and it is coupled to various cellular processes ranging from endocytosis to transcription. This multi-potent nature…”
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Deciphering Load-Induced Anchoring by Myosin VI
Published in Biophysical journal (15-02-2019)Get full text
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15
Single-molecule and single-particle imaging of molecular motors in vitro and in vivo
Published in Experientia supplementum (2012) (2014)“…Motor proteins are multi-potent molecular machines, whose localisation, function and regulation are achieved through tightly controlled processes involving…”
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Nuclear Myosin VI Stabilizes RNA Polymerase II in Transcription Factories
Published in Biophysical journal (15-02-2019)Get full text
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Nuclear Myosin VI Regulates Estrogen Receptor Driven Gene Expression
Published in Biophysical journal (15-02-2019)Get full text
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Definition, aims, and implementation of GA2 LEN/HAEi Angioedema Centers of Reference and Excellence
Published in Allergy (Copenhagen) (01-08-2020)Get full text
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19
Fluorescence and labelling: how to choose and what to do
Published in Experientia supplementum (2012) (2014)“…This chapter provides an overview of fluorescent labelling of different reactants related to the biochemistry of motor proteins. The fluorescent properties of…”
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Myosin VI Comes Together - Structure and Motor Regulation by Binding Partners
Published in Biophysical journal (31-01-2012)Get full text
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