Zornioside, a dihydrochalcone C-glycoside, and other compounds from Zornia brasiliensis

[Display omitted] The secondary metabolites of the aerial parts of Zornia brasiliensis Vogel, Fabaceae, and the biological activity of one of these secondary metabolites were characterized in this study. A phytochemical investigation was performed using chromatographic techniques including analytica...

Full description

Saved in:

Bibliographic Details
Published in:	Revista brasileira de farmacognosia Vol. 28; no. 2; pp. 192 - 197
Main Authors:	Nascimento, Yuri M., Abreu, Lucas S., Lima, Ramon L., Silva, Anne Dayse S., Costa, Vicente Carlos O., Melo, José Iranildo M., Scotti, Marcus Tulius, Sobral, Marianna V., Araujo, Silvany S., Filho, Manoel Adrião G., Silva, Marcelo S., Tavares, Josean F.
Format:	Journal Article
Language:	English
Published:	Cham Elsevier Editora Ltda 01-03-2018 Springer International Publishing Sociedade Brasileira de Farmacognosia
Subjects:	Cytotoxic activity Dihydrochalcone Glycosylated megastigmane Isoflavonoid Original Article PHARMACOLOGY & PHARMACY Pharmacy Phenolic compounds Pterocarpan Pterocarpan Glycosylated megastigmane Phenolic compounds Isoflavonoid Dihydrochalcone Cytotoxic activity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] The secondary metabolites of the aerial parts of Zornia brasiliensis Vogel, Fabaceae, and the biological activity of one of these secondary metabolites were characterized in this study. A phytochemical investigation was performed using chromatographic techniques including analytical and preparative reverse-phase HPLC column sequences, which resulted in the isolation of fourteen compounds: one previously undescribed C-glycosylated dihydrochalcone (zornioside), one cyclitol (D-pinitol), one glycosylated megastigmane (roseoside) and eleven phenolic compounds: 7-methoxyflavanone, 7,4′-dimethoxyisoflavone, medicarpin, 2′-4′-dihydroxychalcone, onionin, isoorientin-3′-O-methyl ether, isovitexin, glycosylated (Z)-O-coumaric acid, glycosylated (E)-O-coumaric acid, dihydromelilotoside, and isoorientin. The structures of the isolated compounds were determined based on 1D and 2D-NMR, HRESIMS, IR and CD spectroscopic analyses. The cytotoxic activity of zornoside was assessed against tumor cell lines (MCF-7, HCC1954, T-47D, 4T1, HL60), and a non-tumor cell line (RAW264.7) using MTT assay. The compound zornioside was selectively cytotoxic for HL60 leukemia cells (IC50: 37.26μM).
ISSN:	0102-695X 1981-528X 1981-528X
DOI:	10.1016/j.bjp.2018.02.003