Etiology of childhood diarrhea in the northeast of Brazil: significant emergent diarrheal pathogens

Abstract In a study conducted in João Pessoa, northeast of Brazil, 2344 Escherichia coli isolated from 290 infants with diarrhea and 290 healthy matched controls were analyzed for virulence traits. Enteroaggregative E. coli (EAEC) was the most prevalent pathogen associated to acute diarrhea. Based o...

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Bibliographic Details
Published in:	Diagnostic microbiology and infectious disease Vol. 66; no. 1; pp. 50 - 57
Main Authors:	Moreno, Ana Carolina Ramos, Filho, Antônio Fernandes, Gomes, Tânia do Amaral Tardelli, Ramos, Sônia T.S, Montemor, Liana P.G, Tavares, Vanessa C, Filho, Lauro dos Santos, Irino, Kinue, Martinez, Marina Baquerizo
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 2010
Subjects:	Atypical EPEC Brazil - epidemiology Campylobacter Case-Control Studies Cell Adhesion Cell Line, Tumor Chi-Square Distribution Diarrhea Diarrhea, Infantile - epidemiology Diarrhea, Infantile - microbiology Diarrheagenic E. coli EAEC Entamoeba histolytica Enteropathogenic Escherichia coli - classification Enteropathogenic Escherichia coli - genetics Enteropathogens Epidemiologic study Escherichia coli Escherichia coli - classification Escherichia coli - genetics Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Feces - microbiology Giardia lamblia Gram-Negative Bacteria - classification Gram-Negative Bacteria - genetics Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - microbiology Humans Infant Infectious Disease Internal Medicine Prevalence Salmonella Serotyping Shigella Virulence Brazil Diarrhea Enteropathogens EAEC Epidemiologic study Diarrheagenic E. coli Atypical EPEC
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Summary:	Abstract In a study conducted in João Pessoa, northeast of Brazil, 2344 Escherichia coli isolated from 290 infants with diarrhea and 290 healthy matched controls were analyzed for virulence traits. Enteroaggregative E. coli (EAEC) was the most prevalent pathogen associated to acute diarrhea. Based on the results of colony blot hybridization, serotyping, and HEp-2 cell adherence assays, strains were separated in categories as typical enteropathogenic E. coli (EPEC) (1.7%), atypical EPEC (a-EPEC) (9.3%), EAEC (25%), enterotoxigenic E. coli (10%), and enteroinvasive E. coli (EIEC) (1.4%). No enterohemorrhagic E. coli strains were isolated. Other enteropathogens were found, including Salmonella (7.9%), Shigella spp. (4.1%), thermophilic Campylobacter spp. (2.4%), Giardia lamblia (9.3%), and Entamoeba histolytica (5.8%). All enteropathogens were associated with diarrhea ( P < 0.01). However, the association was lower for EPEC and EIEC ( P < 0.03). Different pathogens associated with diarrhea may have been changing in Brazil where EAEC and a-EPEC seem to be the most prevalent pathogens among them.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2008.03.017