Search Results - "Filho, José Carlos Alves"

Purinergic Cooperation Between P2Y2 and P2X7 Receptors Promote Cutaneous Leishmaniasis Control: Involvement of Pannexin-1 and Leukotrienes by Thorstenberg, Maria Luiza, Rangel Ferreira, Marcos Vinícius, Amorim, Natália, Canetti, Claudio, Morrone, Fernanda B., Alves Filho, José Carlos, Coutinho-Silva, Robson

“…The release of damage-associated molecular patterns, including uridine triphosphate (UTP) and adenosine triphosphate (ATP) to the extracellular milieu is a key…”
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SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology by Veras, Flavio Protasio, Pontelli, Marjorie Cornejo, Silva, Camila Meirelles, Toller-Kawahisa, Juliana E, de Lima, Mikhael, Nascimento, Daniele Carvalho, Schneider, Ayda Henriques, Caetité, Diego, Tavares, Lucas Alves, Paiva, Isadora M, Rosales, Roberta, Colón, David, Martins, Ronaldo, Castro, Italo Araujo, Almeida, Glaucia M, Lopes, Maria Isabel Fernandes, Benatti, Maíra Nilson, Bonjorno, Letícia Pastorelli, Giannini, Marcela Cavichioli, Luppino-Assad, Rodrigo, Almeida, Sérgio Luna, Vilar, Fernando, Santana, Rodrigo, Bollela, Valdes R, Auxiliadora-Martins, Maria, Borges, Marcos, Miranda, Carlos Henrique, Pazin-Filho, Antônio, da Silva, Luis Lamberti P, Cunha, Larissa Dias, Zamboni, Dario S, Dal-Pizzol, Felipe, Leiria, Luiz O, Siyuan, Li, Batah, Sabrina, Fabro, Alexandre, Mauad, Thais, Dolhnikoff, Marisa, Duarte-Neto, Amaro, Saldiva, Paulo, Cunha, Thiago Mattar, Alves-Filho, José Carlos, Arruda, Eurico, Louzada-Junior, Paulo, Oliveira, Renê Donizeti, Cunha, Fernando Queiroz

“…Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering…”
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PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation by Damasceno, Luis Eduardo Alves, Prado, Douglas Silva, Veras, Flavio Protasio, Fonseca, Miriam M, Toller-Kawahisa, Juliana E, Rosa, Marcos Henrique, Públio, Gabriel Azevedo, Martins, Timna Varela, Ramalho, Fernando S, Waisman, Ari, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Alves-Filho, José Carlos

“…Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing shifts toward glycolysis. Here, we show that the pyruvate kinase M2…”
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Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis by Czaikoski, Paula Giselle, Mota, José Maurício Segundo Correia, Nascimento, Daniele Carvalho, Sônego, Fabiane, Castanheira, Fernanda Vargas e Silva, Melo, Paulo Henrique, Scortegagna, Gabriela Trentin, Silva, Rangel Leal, Barroso-Sousa, Romualdo, Souto, Fabrício Oliveira, Pazin-Filho, Antonio, Figueiredo, Florencio, Alves-Filho, José Carlos, Cunha, Fernando Queiróz

“…Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high mortality rate. Neutrophil extracellular traps (NETs) have been…”
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Hydrogen Sulfide Augments Neutrophil Migration through Enhancement of Adhesion Molecule Expression and Prevention of CXCR2 Internalization: Role of ATP-Sensitive Potassium Channels by Dal-Secco, Daniela, Cunha, Thiago M, Freitas, Andressa, Alves-Filho, Jose Carlos, Souto, Fabricio O, Fukada, Sandra Y, Grespan, Renata, Alencar, Nylane M. N, Neto, Alberto F, Rossi, Marcos A, Ferreira, Sergio H, Hothersall, John S, Cunha, Fernando Q

“…In this study, we have addressed the role of H(2)S in modulating neutrophil migration in either innate (LPS-challenged naive mice) or adaptive (methylated BSA…”
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STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection by Gomes, Marco Tulio R, Guimarães, Erika S, Marinho, Fabio V, Macedo, Isabella, Aguiar, Eric R G R, Barber, Glen N, Moraes-Vieira, Pedro M M, Alves-Filho, José Carlos, Oliveira, Sergio C

“…Macrophages metabolic reprogramming in response to microbial insults is a major determinant of pathogen growth or containment. Here, we reveal a distinct…”
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Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious by Sônego, Fabiane, Castanheira, Fernanda Vargas E Silva, Ferreira, Raphael Gomes, Kanashiro, Alexandre, Leite, Caio Abner Vitorino Gonçalves, Nascimento, Daniele Carvalho, Colón, David Fernando, Borges, Vanessa de Fátima, Alves-Filho, José Carlos, Cunha, Fernando Queiróz

“…Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide. Neutrophils…”
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The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils by Toller-Kawahisa, Juliana Escher, Hiroki, Carlos Hiroji, Silva, Camila Meirelles de Souza, Nascimento, Daniele Carvalho, Públio, Gabriel Azevedo, Martins, Timna Varela, Damasceno, Luis Eduardo Alves, Veras, Flávio Protásio, Viacava, Paula Ramos, Sukesada, Fábio Yuji, Day, Emily Anne, Zotta, Alessia, Ryan, Tristram Alexander Jasper, Moreira da Silva, Rodrigo, Cunha, Thiago Mattar, Lopes, Norberto Peporine, Cunha, Fernando de Queiroz, O’Neill, Luke Anthony John, Alves-Filho, José Carlos

“…Neutrophils rely predominantly on glycolytic metabolism for their biological functions, including reactive oxygen species (ROS) production. Although pyruvate…”
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Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and -independent actions on macrophages by Drehmer, Daiana, Mesquita Luiz, João Paulo, Hernandez, Cesar Augusto Speck, Alves-Filho, José Carlos, Hussell, Tracy, Townsend, Paul Andrew, Moncada, Salvador

“…Production of nitric oxide (NO) has been demonstrated in several malignancies, however its role remains not fully understood, specifically in relation to the…”
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T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections by Santiago-Carvalho, Igor, Almeida-Santos, Gislane, Macedo, Bruna Gois, Barbosa-Bomfim, Caio Cesar, Almeida, Fabricio Moreira, Pinheiro Cione, Marcos Vinícios, Vardam-Kaur, Trupti, Masuda, Mia, Van Dijk, Sarah, Melo, Bruno Marcel, Silva do Nascimento, Rogério, da Conceição Souza, Rebeka, Peixoto-Rangel, Alba Lucínia, Coutinho-Silva, Robson, Hirata, Mario Hiroyuki, Alves-Filho, José Carlos, Álvarez, José Maria, Lassounskaia, Elena, Borges da Silva, Henrique, D’Império-Lima, Maria Regina

“…CD4+ T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4+…”
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Semisynthesis and Cytotoxic Activities of Novel Oxime Ester Derivatives of the Diterpene Stemodin by de Oliveira, José Augusto, Alves Filho, Carlos José, Lima, Antônio Marcelo, do Ó Pessoa, Cláudia, de Oliveira, Fátima de Cássia, Miranda, Fátima, de Mattos, Marcos Carlos, Oliveira, Maria Conceição, Mafezoli, Jair, Barbosa, Francisco Geraldo

“…Stemodin (1) is a diterpene produced by Stemodia maritima L. (Scrophulariaceae) and shows antiviral and tumor cell proliferation inhibitory activities…”
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TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism by de Lima, Kalil Alves, Donate, Paula Barbim, Talbot, Jhimmy, Davoli-Ferreira, Marcela, Peres, Raphael Sanches, Cunha, Thiago Mattar, Alves-Filho, José Carlos, Cunha, Fernando Queiroz

“…The aryl hydrocarbon receptor (AHR) is a transcription factor activated by ligand highly expressed on T H 17 cells, and AHR-deficient CD4 + T cells have…”
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Cardiovascular and Autonomic Dysfunction in Murine Ligature-Induced Periodontitis by Ribeiro, Aline Barbosa, Santos-Junior, Nilton Nascimento, Luiz, João Paulo Mesquita, de Oliveira, Mauro, Kanashiro, Alexandre, Taira, Thaise Mayumi, Fukada, Sandra Yasuyo, Alves-Filho, José Carlos, Fazan Junior, Rubens, Salgado, Helio Cesar

“…The present study examined the hemodynamics [arterial pressure (AP), AP variability (APV), heart rate (HR), and heart rate variability (HRV)], cardiac function…”
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CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis by Molinaro, Raphael, Pecli, Cyntia, Guilherme, Rafael F, Alves-Filho, José Carlos, Cunha, Fernando Q, Canetti, Claudio, Kunkel, Steven L, Bozza, Marcelo T, Benjamim, Claudia F

“…Sepsis is a deadly disease characterized by an overwhelming release of inflammatory mediators and the activation of different types of cells. This altered…”
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Crucial Role of TNF Receptors 1 and 2 in the Control of Polymicrobial Sepsis by Secher, Thomas, Vasseur, Virginie, Poisson, Didier Marc, Mitchell, Jane A, Cunha, Fernando Q, Alves-Filho, Jose Carlos, Ryffel, Bernhard

“…Sepsis is still a major cause of mortality in the intensive critical care unit and results from an overwhelming immune response to the infection. TNF signaling…”
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P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis by Santiago-Carvalho, Igor, Almeida-Santos, Gislane de, Bomfim, Caio César Barbosa, Souza, Paula Carolina de, Silva, Juan Carlo Santos e, Melo, Bruno Marcel Silva de, Amaral, Eduardo Pinheiro, Cione, Marcos Vinícios Pinheiro, Lasunskaia, Elena, Hirata, Mario Hiroyuki, Alves-Filho, José Carlos Farias, Nakaya, Helder Imoto, Alvarez, José Maria, D’Império Lima, Maria Regina

“…The risk of developing severe forms of tuberculosis has increased by the acquired immunodeficiency syndrome (AIDS) epidemic, lack of effective drugs to…”
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The Role of ST2 Receptor in the Regulation of Brucella abortus Oral Infection by Santos, Raiany, Campos, Priscila C, Rungue, Marcella, Rocha, Victor, Santos, David, Mendes, Viviani, Marinho, Fabio V, Martins, Flaviano, Ricci, Mayra F, Reis, Diego C Dos, Cassali, Geovanni D, Alves-Filho, José Carlos, Vieira, Angelica T, Oliveira, Sergio C

“…The ST2 receptor plays an important role in the gut such as permeability regulation, epithelium regeneration, and promoting intestinal immune modulation. Here,…”
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MMP-9 Mediates Cross-Talk between Neutrophils and Endothelial Cells in Psoriasis by Alves-Filho, José Carlos, Marcel Silva Melo, Bruno, Ryffel, Bernhard

“…In their report, Chen et al. provide new insights into psoriasis pathogenesis, showing that neutrophil infiltration of skin lesions increases vascular…”
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Green Enzymatic Synthesis of Geranyl Butyrate: Process Optimization and Mechanistic Insights by Simão Neto, Francisco, Sousa Junior, Paulo Gonçalves de, da Silva Filho, Carlos José Alves, Pinheiro Coutinho, Lucas, Melo, Rafael Leandro Fernandes, Rocha-Martin, Javier, Rios, Maria Alexsandra de Sousa, Sanders Lopes, Ada Amélia, Monteiro, Norberto de K. V., de Mattos, Marcos Carlos, Serafim, Leonardo Farias, Sousa dos Santos, José Cleiton

“…Flavor esters are organic compounds widely used in the food industry to enhance the aroma and taste of products. However, most chemical processes for the…”
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Morphological, cellular, and molecular basis of brain infection in COVID-19 patients by Crunfli, Fernanda, Carregari, Victor C., Veras, Flavio P., Silva, Lucas S., Nogueira, Mateus Henrique, Antunes, André Saraiva Leão Marcelo, Vendramini, Pedro Henrique, Valença, Aline Gazzola Fragnani, Brandão-Teles, Caroline, Zuccoli, Giuliana da Silva, Reis-de-Oliveira, Guilherme, Silva-Costa, Lícia C., Saia-Cereda, Verônica Monteiro, Smith, Bradley J., Codo, Ana Campos, de Souza, Gabriela F, Muraro, Stéfanie P., Parise, Pierina Lorencini, Toledo-Teixeira, Daniel A., Santos de Castro, Ícaro Maia, Melo, Bruno Marcel, Almeida, Glaucia M., Firmino, Egidi Mayara Silva, Paiva, Isadora Marques, Silva, Bruna Manuella Souza, Guimarães, Rafaela Mano, Mendes, Niele D., Ludwig, Raíssa L., Ruiz, Gabriel P., Knittel, Thiago L., Davanzo, Gustavo G., Gerhardt, Jaqueline Aline, Rodrigues, Patrícia Brito, Forato, Julia, Amorim, Mariene Ribeiro, Brunetti, Natália S., Martini, Matheus Cavalheiro, Benatti, Maíra Nilson, Batah, Sabrina S., Siyuan, Li, João, Rafael B., Aventurato, Ítalo K., Rabelo de Brito, Mariana, Mendes, Maria J., da Costa, Beatriz A., Alvim, Marina K. M., da Silva Júnior, José Roberto, Damião, Lívia L., de Sousa, Iêda Maria P., da Rocha, Elessandra D., Gonçalves, Solange M., Lopes da Silva, Luiz H., Bettini, Vanessa, Campos, Brunno M., Ludwig, Guilherme, Tavares, Lucas Alves, Pontelli, Marjorie Cornejo, Viana, Rosa Maria Mendes, Martins, Ronaldo B., Vieira, Andre Schwambach, Alves-Filho, José Carlos, Arruda, Eurico, Podolsky-Gondim, Guilherme Gozzoli, Santos, Marcelo Volpon, Neder, Luciano, Damasio, André, Rehen, Stevens, Vinolo, Marco Aurélio Ramirez, Munhoz, Carolina Demarchi, Louzada-Junior, Paulo, Oliveira, Renê Donizeti, Cunha, Fernando Q., Nakaya, Helder I., Mauad, Thais, Duarte-Neto, Amaro Nunes, Ferraz da Silva, Luiz Fernando, Dolhnikoff, Marisa, Saldiva, Paulo Hilario Nascimento, Farias, Alessandro S., Cendes, Fernando, Moraes-Vieira, Pedro Manoel M., Fabro, Alexandre T., Sebollela, Adriano, Proença-Modena, José L., Yasuda, Clarissa L., Mori, Marcelo A., Cunha, Thiago M., Martins-de-Souza, Daniel

“…Although increasing evidence confirms neuropsychiatric manifestations associated mainly with severe COVID-19 infection, long-term neuropsychiatric dysfunction…”
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