Search Results - "Filer, Danny"

Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity by Martínez Corrales, Guillermo, Filer, Danny, Wenz, Katharina C., Rogan, Abbie, Phillips, George, Li, Mengjia, Feseha, Yodit, Broughton, Susan J., Alic, Nazif

“…Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to…”
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RNA polymerase III limits longevity downstream of TORC1 by Filer, Danny, Thompson, Maximillian A., Takhaveev, Vakil, Dobson, Adam J., Kotronaki, Ilektra, Green, James W. M., Heinemann, Matthias, Tullet, Jennifer M. A., Alic, Nazif

“…RNA polymerase III is a key evolutionarily conserved regulator of longevity that may have potential as a therapeutic target for age-related conditions. Pol III…”
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Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells by Ureña, Enric, Xu, Bowen, Regan, Jennifer C, Atilano, Magda L, Minkley, Lucy J, Filer, Danny, Lu, Yu-Xuan, Bolukbasi, Ekin, Khericha, Mobina, Alic, Nazif, Partridge, Linda

“…Pharmacological therapies are promising interventions to slow down aging and reduce multimorbidity in the elderly. Studies in animal models are the first step…”
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