Search Results - "Filatov, Gregory N"

Hyperpolarized shifts in the voltage dependence of fast inactivation of Nav1.4 and Nav1.5 in a rat model of critical illness myopathy by Filatov, Gregory N., Rich, Mark M.

“…Critical illness myopathy is a disorder in which skeletal muscle becomes electrically inexcitable. We previously demonstrated that a shift in the voltage…”
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Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel by Filatov, G N, Nguyen, T P, Kraner, S D, Barchi, R L

“…The D4/S4-5 interhelical region plays a role in sodium channel fast inactivation. Examination of S4-5 primary structure in all domains suggests a possible…”
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Role of Ca(2+) in injury-induced changes in sodium current in rat skeletal muscle by Filatov, Gregory N, Pinter, Martin J, Rich, Mark M

“…Characteristics of voltage-dependent sodium current recorded from adult rat muscle fibers in loose patch mode were rapidly altered following nearby impalement…”
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Resting potential-dependent regulation of the voltage sensitivity of sodium channel gating in rat skeletal muscle in vivo by Filatov, Gregory N, Pinter, Martin J, Rich, Mark M

“…Normal muscle has a resting potential of -85 mV, but in a number of situations there is depolarization of the resting potential that alters excitability. To…”
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Hyperpolarized shifts in the voltage dependence of fast inactivation of Na v 1.4 and Na v 1.5 in a rat model of critical illness myopathy by Filatov, Gregory N., Rich, Mark M.

“…Critical illness myopathy is a disorder in which skeletal muscle becomes electrically inexcitable. We previously demonstrated that a shift in the voltage…”
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The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating by Filatov, G N, White, M M

“…A highly conserved leucine is found in the middle of the porelining (M2) domain of the members of the ligand-gated ion channel family. Two very different roles…”
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Analysis of Local Structure in the D2/S1–S2 Region of the Rat Skeletal Muscle Type 1 Sodium Channel Using Insertional Mutagenesis by Kraner, Susan D., Filatov, Gregory N., Sun, Weijing, Bannerman, Peter, Lindstrom, Jon, Barchi, Robert L.

“…: A reporter epitope was inserted at 11 positions in a region encompassing proposed transmembrane segments S1 and S2 in the second repeat domain (D2) of the…”
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Selective enhancement of the interaction of curare with the nicotinic acetylcholine receptor by Filatov, G N, Aylwin, M L, White, M M

“…Alteration of the ligand-binding domain of the nicotinic acetylcholine receptor through site-directed mutagenesis offers a powerful approach to the elucidation…”
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