Patterns of diagnostic procedures for lung cancer pathology in the Middle East and North Africa

Accurate pathological diagnosis is the first critical step in the management of lung cancer. This step is important to determine the histological subtype of the cancer and to identify any actionable targets. Our study aimed at evaluating the patterns of procedures used to obtain pathological diagnos...

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Bibliographic Details
Published in:	Journal of thoracic disease Vol. 11; no. 12; pp. 5162 - 5168
Main Authors:	Jazieh, Abdul Rahman, Bounedjar, Adda, Al Dayel, Foad, Fahem, Shamayel, Tfayli, Arafat, Rasul, Kakil, Jaafar, Hassan, Jaloudi, Mohammad, Al Fayea, Turki, Almaghrabi, Hatim Q, Bamefleh, Hanaa, AlKattan, Khaled, Larbaoui, Blaha, Filalli, Taha, Al Mistiri, Mufid, Alhusaini, Hamed
Format:	Journal Article
Language:	English
Published:	China AME Publishing Company 01-12-2019
Subjects:	Original work-up pathology diagnostic procedures Lung cancer
Online Access:	Get full text
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Summary:	Accurate pathological diagnosis is the first critical step in the management of lung cancer. This step is important to determine the histological subtype of the cancer and to identify any actionable targets. Our study aimed at evaluating the patterns of procedures used to obtain pathological diagnosis of lung cancer in the Middle East and North Africa (MENA) Region. Data of consecutive patients with the diagnosis of non-small cell lung cancer (NSCLC) were collected from participating centers from different countries in the MENA Region. Methods of obtaining tissue diagnosis and workup were analyzed to determine the practice patterns of obtaining tissue diagnosis of lung cancer. A total of 566 patients were recruited from 10 centers in 5 countries including Saudi Arabia, United Arab Emirates (UAE), Qatar, Lebanon and Algeria. Majority of patients were males (78.1%) with a median age of 61 years (range, 22-89 years). Obtaining tissue diagnosis was successful in the first attempt in 72.3% of patients, while 16.4% and 6.3% of patients required 2 and 3 attempt, respectively. The success in first attempt was as follows: image guided biopsy (91%), surgical biopsy (88%), endobronchial biopsy (79%) and cytology (30%). The success in the second attempt was as follows; surgical biopsy (100%), image guided biopsy (95%), endobronchial biopsy (65%), cytology (25%). More than quarter of the patients required repeated biopsy in the MENA Region. Image guided biopsy has the highest initial yield. Implementing clear process and multidisciplinary guidelines about the selection of diagnostic procedures is needed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributions: (I) Conception and design: AR Jazieh; (II) Administrative support: AR Jazieh; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: AR Jazieh; (V) Data analysis and interpretation: AR Jazieh; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
ISSN:	2072-1439 2077-6624
DOI:	10.21037/jtd.2019.12.03