Search Results - "Fikes, John"

A Degenerate HLA-DR Epitope Pool of HER-2/neu Reveals a Novel In vivo Immunodominant Epitope, HER-2/neu88-102 by KARYAMPUDI, Lavakumar, FORMICOLA, Courtney, HARTMANN, Lynn C, DISIS, Mary L, FERRONE, Soldano, ISHIOKA, Glenn, KNUTSON, Keith L, ERSKINE, Courtney L, MAURER, Matthew J, INGLE, James N, KRCO, Christopher J, WETTSTEIN, Peter J, KALLI, Kimberly R, FIKES, John D, BEEBE, Melanie

“…Purpose: Over the past two decades, there has been significant interest in targeting HER-2/neu in immune-based approaches for the treatment of HER-2/neu+…”
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Immunization of Cancer Patients with HER-2/neu-Derived Peptides Demonstrating High-Affinity Binding to Multiple Class II Alleles by SALAZAR, Lupe G, FIKES, John, SOUTHWOOD, Scott, ISHIOKA, Glenn, KNUTSON, Keith L, GOOLEY, Theodore A, SCHIFFMAN, Kathy, DISIS, Mary L

“…Purpose: The purpose of this study was to immunize patients with HER-2/ neu -overexpressing cancer with a multipeptide vaccine comprised of four class II…”
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An HLA-DR-degenerate epitope pool detects insulin-like growth factor binding protein 2-specific immunity in patients with cancer by Kalli, Kimberly R, Krco, Christopher J, Hartmann, Lynn C, Goodman, Karin, Maurer, Matthew J, Yu, Chao, Johnson, Elliot M, Erskine, Courtney L, Disis, Mary L, Wettstein, Peter J, Fikes, John D, Beebe, Melanie, Ishioka, Glenn, Knutson, Keith L

“…Recent studies have shown the importance of helper CD4 T cells in initiating and sustaining tumor-specific CD8 T-cell immunity. This has paved the way for…”
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Identification of a broad coverage HLA-DR degenerate epitope pool derived from carcinoembryonic antigen by Karyampudi, Lavakumar, Krco, Christopher J, Kalli, Kimberly R, Erskine, Courtney L, Hartmann, Lynn C, Goodman, Karin, Ingle, James N, Maurer, Matthew J, Nassar, Aziza, Yu, Chao, Disis, Mary L, Wettstein, Peter J, Fikes, John D, Beebe, Melanie, Ishioka, Glenn, Knutson, Keith L

“…CD4 T cells are important for anti-tumor immune responses. Aside from their role in the activation of CD8 T cells, CD4 T cells also mediate anti-tumor immune…”
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Design of multi-epitope, analogue-based cancer vaccines by Fikes, John D, Sette, Alessandro

“…The current objective of our cancer programme is to develop an effective vaccine based on rationally designed T cell epitope analogues, for use in the adjuvant…”
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Identification of Novel HLA-A2-Restricted Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Epitopes Predicted by the HLA-A2 Supertype Peptide-Binding Motif by Altfeld, M A, Livingston, B, Reshamwala, N, Nguyen, P T, Addo, M M, Shea, A, Newman, M, Fikes, J, Sidney, J, Wentworth, P, Chesnut, R, Eldridge, R L, Rosenberg, E S, Robbins, G K, Brander, C, Sax, P E, Boswell, S, Flynn, T, Buchbinder, S, Goulder, P J, Walker, B D, Sette, A, Kalams, S A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Screening of HLA-A24-restricted Epitope Peptides from Prostate-specific Membrane Antigen That Induce Specific Antitumor Cytotoxic T Lymphocytes by HORIGUCHI, Yutaka, NUKAYA, Ikuei, OKAZAWA, Kazuhide, KAWASHIMA, Ichiro, FIKES, John, SETTE, Allesandro, TACHIBANA, Masaaki, TAKESAKO, Kazutoh, MURAI, Masaru

“…Purpose: Prostate-specific membrane antigen (PSMA), which is a transmembrane glycoprotein predominantly expressed in prostate cancer, is an attractive target…”
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Formulation and characterization of a ten-peptide single-vial vaccine EP-2101, designed to induce cytotoxic T-lymphocyte responses for cancer immunotherapy by Beebe, Melanie, Qin, Mingsheng, Moi, Michael, Wu, Sharon, Heiati, Hashem, Walker, Les, Newman, Mark, Fikes, John, Ishioka, Glenn Y.

“…Effective vaccines that mediate clinical responses in cancer patients may require generation of broadly specific cytotoxic T lymphocytes (CTL) directed against…”
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In-Space Cryogenic Propellant Depot stepping stone by Howell, Joe T., Mankins, John C., Fikes, John C.

“…An In-Space Cryogenic Propellant Depot (ISCPD) is an important stepping stone to provide the capability to preposition, store, manufacture, and later use the…”
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Epitope-based vaccines: an update on epitope identification, vaccine design and delivery by Sette, Alessandro, Fikes, John

“…The basic premise of the epitope-based approach to vaccine development is that, in certain cases, the responses induced by the natural immunogen are not…”
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Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae by Fikes, John D, Becker, Daniel M, Winston, Fred, Guarente, Leonard

“…Eukaryotic promoters contain binding sites for basic transcription factors and gene-specific activator proteins. The transcription factors interact at the TATA…”
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Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity by Alexander, Jeff, Del Guercio, Marie-France, Fikes, John D, Chesnut, Robert W, Chisari, Francis V, Chang, Kyong-Mi, Appella, Ettore, Sette, Alessandro

“…Using short term CTL lines derived from HLA A2/K b transgenic mice and IFN-gamma release assays we demonstrate that the NS4.1769 epitope, is generated from…”
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Identification of New Epitopes from Four Different Tumor-Associated Antigens: Recognition of Naturally Processed Epitopes Correlates with HLA-A0201-Binding Affinity by Keogh, Elissa, Fikes, John, Southwood, Scott, Celis, Esteban, Chesnut, Robert, Sette, Alessandro

“…Forty-two wild-type and analogue peptides derived from p53, carcinoembryonic Ag, Her2/neu, and MAGE2/3 were screened for their capacity to induce CTLs, in…”
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Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide by Tangri, S, Ishioka, G Y, Huang, X, Sidney, J, Southwood, S, Fikes, J, Sette, A

“…Certain peptide analogs that carry substitutions at residues other than the main major histocompatibility complex anchors and are surprisingly much more…”
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A pilot study of the CY‐1899 T‐cell vaccine in subjects chronically infected with hepatitis B virus by Heathcote, Jenny, McHutchison, John, Lee, Samuel, Tong, Myron, Benner, Kent, Minuk, Gerald, Wright, Teresa, Fikes, John, Livingston, Brian, Sette, Alex, Chestnut, Robert

“…Clinical observations suggest that eradication of the hepatitis B virus (HBV) is immune‐mediated. Vigorous cytotoxic T lymphocyte (CTL) activity directed at…”
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Linear PADRE T Helper Epitope and Carbohydrate B Cell Epitope Conjugates Induce Specific High Titer IgG Antibody Responses by Alexander, Jeff, del Guercio, Marie-France, Maewal, Ajesh, Qiao, Lei, Fikes, John, Chesnut, Robert W, Paulson, James, Bundle, David R, DeFrees, Shawn, Sette, Alessandro

“…Linear carbohydrate-peptide constructs based on the 13 amino acid nonnatural pan DR epitope (PADRE) and carbohydrate B cell epitopes are demonstrated to be…”
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Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes by Ishioka, Glenn Y, Fikes, John, Hermanson, Gary, Livingston, Brian, Crimi, Claire, Qin, Mingsheng, France del Guercio, Marie, Oseroff, Carla, Dahlberg, Carol, Alexander, Jeff, Chesnut, Robert W, Sette, Alessandro

“…We engineered a multiepitope DNA minigene encoding nine dominant HLA-A2.1- and A11-restricted epitopes from the polymerase, envelope, and core proteins of…”
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Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLs by MIMURA, Kousaku, KONO, Koji, SOUTHWOOD, Scott, FIKES, John, TAKAHASHI, Akihiro, MIYAGAWA, Naoto, SUGAI, Hidemitsu, FUJII, Hideki

“…In order to broaden the possibility for anti-HER-2/neu (HER-2) immune targeting, it is important to identify HLA-A24 restricted peptide epitopes derived from…”
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Altered Helper T Lymphocyte Function Associated with Chronic Hepatitis B Virus Infection and its Role in Response to Therapeutic Vaccination in Humans by Livingston, Brian D, Alexander, Jeff, Crimi, Claire, Oseroff, Carla, Celis, Esteban, Daly, Kieran, Guidotti, Luca G, Chisari, Francis V, Fikes, John, Chesnut, Robert W, Sette, Alessandro

“…Theradigm-hepatitis B virus (HBV) is an experimental lipopeptide vaccine designed to stimulate induction of HBV-specific CTL responses in HLA-A2 individuals…”
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A decaepitope polypeptide primes for multiple CD8+ IFN-gamma and Th lymphocyte responses: evaluation of multiepitope polypeptides as a mode for vaccine delivery by Alexander, Jeff, Oseroff, Carla, Dahlberg, Carol, Qin, Mingsheng, Ishioka, Glenn, Beebe, Melanie, Fikes, John, Newman, Mark, Chesnut, Robert W, Morton, Phillip A, Fok, Kam, Appella, Ettore, Sette, Alessandro

“…Proteins are generally regarded as ineffective immunogens for CTL responses. We synthesized a 100-mer decaepitope polypeptide and tested its capacity to induce…”
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