Search Results - "Fike, Adam"

Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG by Kumova, Ogan K, Fike, Adam J, Thayer, Jillian L, Nguyen, Linda T, Mell, Joshua Chang, Pascasio, Judy, Stairiker, Christopher, Leon, Leticia G, Katsikis, Peter D, Carey, Alison J

“…Respiratory viral infections contribute substantially to global infant losses and disproportionately affect preterm neonates. Using our previously established…”
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The native ORAI channel trio underlies the diversity of Ca2+ signaling events by Yoast, Ryan E., Emrich, Scott M., Zhang, Xuexin, Xin, Ping, Johnson, Martin T., Fike, Adam J., Walter, Vonn, Hempel, Nadine, Yule, David I., Sneyd, James, Gill, Donald L., Trebak, Mohamed

“…The essential role of ORAI1 channels in receptor-evoked Ca 2+ signaling is well understood, yet little is known about the physiological activation of the ORAI…”
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Dissecting the defects in the neonatal CD8+ T‐cell response by Fike, Adam J., Kumova, Ogan K., Carey, Alison J.

“…The neonatal period presents a complex scenario where the threshold of reactivity toward colonizing microbiota, maternal antigens, autoantigens, and pathogens…”
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Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity by Chodisetti, Sathi Babu, Fike, Adam J, Domeier, Phillip P, Singh, Harinder, Choi, Nicholas M, Corradetti, Chelsea, Kawasawa, Yuka Imamura, Cooper, Timothy K, Caricchio, Roberto, Rahman, Ziaur S M

“…TLR7 is associated with development of systemic lupus erythematosus (SLE), but the underlying mechanisms are incompletely understood. Although TLRs are known…”
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The Post-GWAS Era: How to Validate the Contribution of Gene Variants in Lupus by Fike, Adam J., Elcheva, Irina, Rahman, Ziaur S. M.

“…Purpose of Review Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic associations. Here, we provide an update on recent…”
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Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155 by Stelekati, Erietta, Chen, Zeyu, Manne, Sasikanth, Kurachi, Makoto, Ali, Mohammed-Alkhatim, Lewy, Keith, Cai, Zhangying, Nzingha, Kito, McLane, Laura M., Hope, Jennifer L., Fike, Adam J., Katsikis, Peter D., Wherry, E. John

“…Persistent viral infections and tumors drive development of exhausted T (TEX) cells. In these settings, TEX cells establish an important host-pathogen or…”
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The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes by Emrich, Scott M., Yoast, Ryan E., Fike, Adam J., Bricker, Kristen N., Xin, Ping, Zhang, Xuexin, Rahman, Ziaur S.M., Trebak, Mohamed

“…•NCLX has minor, if any, contribution to mitochondrial Ca2+ extrusion in B cells.•NCLX is required for optimal SOCE activity in B cells.•NCLX knockout does not…”
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STAT3 signaling in B cells controls germinal center zone organization and recycling by Fike, Adam J., Chodisetti, Sathi Babu, Wright, Nathaniel E., Bricker, Kristen N., Domeier, Phillip P., Maienschein-Cline, Mark, Rosenfeld, Aaron M., Luckenbill, Sara A., Weber, Julia L., Choi, Nicholas M., Luning Prak, Eline T., Mandal, Malay, Clark, Marcus R., Rahman, Ziaur S.M.

“…Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for…”
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Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells by Emrich, Scott M, Yoast, Ryan E, Zhang, Xuexin, Fike, Adam J, Wang, Yin-Hu, Bricker, Kristen N, Tao, Anthony Y, Xin, Ping, Walter, Vonn, Johnson, Martin T, Pathak, Trayambak, Straub, Adam C, Feske, Stefan, Rahman, Ziaur S M, Trebak, Mohamed

“…The essential role of store-operated Ca entry (SOCE) through Ca release-activated Ca (CRAC) channels in T cells is well established. In contrast, the…”
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Context-Dependent miR-21 Regulation of TLR7-Mediated Autoimmune and Foreign Antigen-Driven Antibody-Forming Cell and Germinal Center Responses by Schell, Stephanie L, Bricker, Kristen N, Fike, Adam J, Chodisetti, Sathi Babu, Domeier, Phillip P, Choi, Nicholas M, Fasnacht, Melinda J, Luckenbill, Sara A, Ziegler, Steven F, Rahman, Ziaur S M

“…MicroRNAs (miRNAs) are involved in healthy B cell responses and the loss of tolerance in systemic lupus erythematosus (SLE), although the role of many miRNAs…”
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Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development by Chodisetti, Sathi Babu, Fike, Adam J, Domeier, Phillip P, Schell, Stephanie L, Mockus, Taryn E, Choi, Nicholas M, Corradetti, Chelsea, Hou, Baidong, Atkins, Hannah M, Caricchio, Roberto, Decker, Thomas, Lukacher, Aron E, Olsen, Nancy, Rahman, Ziaur S M

“…Although STAT1 tyrosine-701 phosphorylation (designated STAT1-pY701) is indispensable for STAT1 function, the requirement for STAT1 serine-727 phosphorylation…”
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Neonatal influenza‐specific effector CTLs retain elevated CD31 levels at the site of infection and have decreased IFN‐γ production by Fike, Adam J., Kumova, Ogan K., Tardif, Virginie J., Carey, Alison J.

“…The underlying mechanisms that regulate neonatal immune suppression are poorly characterized. CD31 (PECAM1) is highly expressed on neonatal lymphocytes and is…”
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TLR7 Negatively Regulates B10 Cells Predominantly in an IFNγ Signaling Dependent Manner by Chodisetti, Sathi Babu, Fike, Adam J, Domeier, Phillip P, Choi, Nicholas M, Soni, Chetna, Rahman, Ziaur S M

“…IL-10 producing B cells (B10 cells) play an important immunoregulatory role in various autoimmune and infection conditions. However, the factors that regulate…”
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Characterization of CD31 expression on murine and human neonatal T lymphocytes during development and activation by Fike, Adam J, Nguyen, Linda T, Kumova, Ogan K, Carey, Alison J

“…Background CD31, expressed by the majority of the neonatal T-cell pool, is involved in modulation of T-cell receptor signaling by increasing the threshold for…”
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Public Clonotypes and Convergent Recombination Characterize the Naïve CD8 + T-Cell Receptor Repertoire of Extremely Preterm Neonates by Carey, Alison J, Hope, Jennifer L, Mueller, Yvonne M, Fike, Adam J, Kumova, Ogan K, van Zessen, David B H, Steegers, Eric A P, van der Burg, Mirjam, Katsikis, Peter D

“…Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported…”
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Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections by Gracias, Donald T, Boesteanu, Alina C, Fraietta, Joseph A, Hope, Jennifer L, Carey, Alison J, Mueller, Yvonne M, Kawalekar, Omkar U, Fike, Adam J, June, Carl H, Katsikis, Peter D

“…The p110δ isoform of PI3K is known to play an important role in immunity, yet its contribution to CTL responses has not been fully elucidated. Using murine…”
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The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8 + T Cells via SHIP-1 by Hope, Jennifer L, Stairiker, Christopher J, Spantidea, Panagiota I, Gracias, Donald T, Carey, Alison J, Fike, Adam J, van Meurs, Marjan, Brouwers-Haspels, Inge, Rijsbergen, Laurine C, Fraietta, Joseph A, Mueller, Yvonne M, Klop, Rosemarieke C, Stelekati, Erietta, Wherry, E John, Erkeland, Stefan J, Katsikis, Peter D

“…We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8 T lymphocytes (CTL) generation…”
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STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses by Fike, Adam J, Chodisetti, Sathi Babu, Bricker, Kristen N, Choi, Nicholas M, Chroneos, Zissis C, Kaplan, Mark H, Rahman, Ziaur S M

“…Genome-wide association studies identified variants in the transcription factor gene and several other genes in the STAT4 signaling pathway, such as , , , and…”
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Strain-Dependent Contribution of MAVS to Spontaneous Germinal Center Responses by Schell, Stephanie L, Chodisetti, Sathi Babu, Fike, Adam J, Choi, Nicholas M, Bricker, Kristen N, Rahman, Ziaur S M

“…Germinal centers (GCs) are essential for the production of somatically hypermutated, class-switched Abs that are protective against infection, but they also…”
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miR-21 promotes B cell autoreactivity, inflammatory signaling, and metabolism in TLR7-driven systemic autoimmunity by Bricker, Kristen N, Fike, Adam J, Luckenbill, Sara A, Weber, Julia L, Jackson, Jasmine S, Olsen, Nancy J, Rahman, Ziaur

“…MicroRNA-21 (miR-21) is upregulated in SLE patients and promotes disease in multiple autoimmune mouse models; however, mechanisms by which miR-21 promote…”
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