Search Results - "Fijen, Carel"

The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair by Fijen, Carel, Rothenberg, Eli

“…•We discuss the current knowledge about the function of biomolecular condensates in DNA repair.•We describe the role of RNA and RNA binding proteins in the…”
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Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study by Hellenkamp, Björn, Schmid, Sonja, Doroshenko, Olga, Opanasyuk, Oleg, Kühnemuth, Ralf, Rezaei Adariani, Soheila, Ambrose, Benjamin, Aznauryan, Mikayel, Barth, Anders, Birkedal, Victoria, Bowen, Mark E., Chen, Hongtao, Cordes, Thorben, Eilert, Tobias, Fijen, Carel, Gebhardt, Christian, Götz, Markus, Gouridis, Giorgos, Gratton, Enrico, Ha, Taekjip, Hao, Pengyu, Hanke, Christian A., Hartmann, Andreas, Hendrix, Jelle, Hildebrandt, Lasse L., Hirschfeld, Verena, Hohlbein, Johannes, Hua, Boyang, Hübner, Christian G., Kallis, Eleni, Kapanidis, Achillefs N., Kim, Jae-Yeol, Krainer, Georg, Lamb, Don C., Lee, Nam Ki, Lemke, Edward A., Levesque, Brié, Levitus, Marcia, McCann, James J., Naredi-Rainer, Nikolaus, Nettels, Daniel, Ngo, Thuy, Qiu, Ruoyi, Robb, Nicole C., Röcker, Carlheinz, Sanabria, Hugo, Schlierf, Michael, Schröder, Tim, Schuler, Benjamin, Seidel, Henning, Streit, Lisa, Thurn, Johann, Tinnefeld, Philip, Tyagi, Swati, Vandenberk, Niels, Vera, Andrés Manuel, Weninger, Keith R., Wünsch, Bettina, Yanez-Orozco, Inna S., Michaelis, Jens, Seidel, Claus A. M., Craggs, Timothy D., Hugel, Thorsten

“…Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro…”
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V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery by Christie, Shaun M, Fijen, Carel, Rothenberg, Eli

“…V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via…”
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Collapsed State Mediates the Low Fidelity of the DNA Polymerase β I260 Mutant by Fijen, Carel, Chavira, Cristian, Alnajjar, Khadijeh, Sawyer, Danielle L., Sweasy, Joann B.

“…DNA polymerase β (Pol β) fills single nucleotide gaps during base excision repair. Deficiencies in Pol β can lead to increased mutagenesis and genomic…”
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A Collapsed Fingers Subdomain is the Basis for DNA Polymerase β I260M Mutator Activity by Chavira, Cristian G., Fijen, Carel, Alnajjar, Khadijeh, Sweasy, Joann

“…DNA Polymerase β fills single nucleotide gaps as a part of the Base Excision Repair pathway (BER); thus, deficiencies in Pol β can lead to increased mutation…”
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Sequential requirements for distinct Polθ domains during theta-mediated end joining by Fijen, Carel, Drogalis Beckham, Lea, Terino, Dante, Li, Yuzhen, Ramsden, Dale A, Wood, Richard D, Doublié, Sylvie, Rothenberg, Eli

“…DNA polymerase θ (Polθ) plays a central role in a DNA double-strand break repair pathway termed theta-mediated end joining (TMEJ). TMEJ functions by pairing…”
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A two-step mechanism governing PARP1-DNA retention by PARP inhibitors by Xue, Huijun, Bhardwaj, Amit, Yin, Yandong, Fijen, Carel, Ephstein, Anastasiya, Zhang, Lianglin, Ding, Xia, Pascal, John M., VanArsdale, Todd L., Rothenberg, Eli

“…PARP inhibitors (PARPi) have emerged as promising cancer therapeutics capable of targeting specific DNA repair pathways, but their mechanism of action with…”
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Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes by Fijen, Carel, Mahmoud, Mariam M., Kronenberg, Meike, Kaup, Rebecca, Fontana, Mattia, Towle-Weicksel, Jamie B., Sweasy, Joann B., Hohlbein, Johannes

“…Eukaryotic DNA polymerase β (Pol β) plays an important role in cellular DNA repair, as it fills short gaps in dsDNA that result from removal of damaged bases…”
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DNA Polymerases at Work: Single-Molecule Observations of DNA Synthesis in Real Time by Fijen, Carel

“…This thesis focuses on the characterization of DNA polymerases with single-molecule techniques. More specifically, I aimed to study polymerase processivity and…”
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Studying DNA–protein interactions with single-molecule Förster resonance energy transfer by Farooq, Shazia, Fijen, Carel, Hohlbein, Johannes

“…Single-molecule Förster resonance energy transfer (smFRET) has emerged as a powerful tool for elucidating biological structure and mechanisms on the molecular…”
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Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes by Fijen, Carel, Mahmoud, Mariam M, Kronenberg, Meike, Kaup, Rebecca, Fontana, Mattia, Towle-Weicksel, Jamie B, Sweasy, Joann B, Hohlbein, Johannes

“…Eukaryotic DNA polymerase β (Pol β) plays an important role in cellular DNA repair, as it fills short gaps in dsDNA that result from removal of damaged bases…”
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Publisher Correction: Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study by Hellenkamp, Björn, Schmid, Sonja, Doroshenko, Olga, Opanasyuk, Oleg, Kühnemuth, Ralf, Adariani, Soheila Rezaei, Ambrose, Benjamin, Aznauryan, Mikayel, Barth, Anders, Birkedal, Victoria, Bowen, Mark E., Chen, Hongtao, Cordes, Thorben, Eilert, Tobias, Fijen, Carel, Gebhardt, Christian, Götz, Markus, Gouridis, Giorgos, Gratton, Enrico, Ha, Taekjip, Hao, Pengyu, Hanke, Christian A., Hartmann, Andreas, Hendrix, Jelle, Hildebrandt, Lasse L., Hirschfeld, Verena, Hohlbein, Johannes, Hua, Boyang, Hübner, Christian G., Kallis, Eleni, Kapanidis, Achillefs N., Kim, Jae-Yeol, Krainer, Georg, Lamb, Don C., Lee, Nam Ki, Lemke, Edward A., Levesque, Brié, Levitus, Marcia, McCann, James J., Naredi-Rainer, Nikolaus, Nettels, Daniel, Ngo, Thuy, Qiu, Ruoyi, Robb, Nicole C., Röcker, Carlheinz, Sanabria, Hugo, Schlierf, Michael, Schröder, Tim, Schuler, Benjamin, Seidel, Henning, Streit, Lisa, Thurn, Johann, Tinnefeld, Philip, Tyagi, Swati, Vandenberk, Niels, Vera, Andrés Manuel, Weninger, Keith R., Wünsch, Bettina, Yanez-Orozco, Inna S., Michaelis, Jens, Seidel, Claus A. M., Craggs, Timothy D., Hugel, Thorsten

“…This paper was originally published under standard Springer Nature copyright. As of the date of this correction, the Analysis is available online as an…”
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Erratum to: Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study by Hellenkamp, Björn, Schmid, Sonja, Doroshenko, Olga, Opanasyuk, Oleg, Kühnemuth, Ralf, Adariani, Soheila Rezaei, Ambrose, Benjamin, Aznauryan, Mikayel, Barth, Anders, Birkedal, Victoria, Bowen, Mark E, Chen, Hongtao, Cordes, Thorben, Eilert, Tobias, Fijen, Carel, Gebhardt, Christian, Götz, Markus, Gouridis, Giorgos, Gratton, Enrico, Ha, Taekjip, Hao, Pengyu, Hanke, Christian A, Hartmann, Andreas, Hendrix, Jelle, Hildebrandt, Lasse L, Hirschfeld, Verena, Hohlbein, Johannes, Hua, Boyang, Hübner, Christian G, Kallis, Eleni, Kapanidis, Achillefs N, Kim, Jae Yeol, Krainer, Georg, Lamb, Don C, Lee, Nam Ki, Lemke, Edward A, Levesque, Brié, Levitus, Marcia, McCann, James J, Naredi-Rainer, Nikolaus, Nettels, Daniel, Ngo, Thuy, Qiu, Ruoyi, Robb, Nicole C, Röcker, Carlheinz, Sanabria, Hugo, Schlierf, Michael, Schröder, Tim, Schuler, Benjamin, Seidel, Henning

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Precision and accuracy of single-molecule FRET measurements - a worldwide benchmark study by Hellenkamp, Björn, Schmid, Sonja, Doroshenko, Olga, Opanasyuk, Oleg, Kühnemuth, Ralf, Adariani, Soheila Rezaei, Barth, Anders, Birkedal, Victoria, Bowen, Mark E, Chen, Hongtao, Cordes, Thorben, Eilert, Tobias, Fijen, Carel, Götz, Markus, Gouridis, Giorgos, Gratton, Enrico, Ha, Taekjip, Hanke, Christian A, Hartmann, Andreas, Hendrix, Jelle, Hildebrandt, Lasse L, Hohlbein, Johannes, Hübner, Christian G, Kallis, Eleni, Kapanidis, Achillefs N, Kim, Jae-Yeol, Krainer, Georg, Lamb, Don C, Lee, Nam Ki, Lemke, Edward A, Levesque, Brié, Levitus, Marcia, McCann, James J, Naredi-Rainer, Nikolaus, Nettels, Daniel, Ngo, Thuy, Qiu, Ruoyi, Röcker, Carlheinz, Sanabria, Hugo, Schlierf, Michael, Schuler, Benjamin, Seidel, Henning, Streit, Lisa, Tinnefeld, Philip, Tyagi, Swati, Vandenberk, Niels, Weninger, Keith R, Wünsch, Bettina, Yanez-Orozco, Inna S, Michaelis, Jens, Seidel, Claus A. M, Craggs, Timothy D, Hugel, Thorsten

“…Natue Methods, vol. 15, pages 669-676, 2018 Single-molecule F\"orster resonance energy transfer (smFRET) is increasingly being used to determine distances,…”
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