Antibiotic resistance of Helicobacter pylori: a cross-sectional study in consecutive patients, and relation to ethnicity

To assess primary antibiotic resistance in a given population and relate the results to ethnicity. Consecutive cultures were tested for antibiotic susceptibility with the Etest. Three populations were studied separately: ethnic Dutch people, patients of Turkish descent, and patients originating from...

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Bibliographic Details
Published in:	Clinical microbiology and infection Vol. 9; no. 7; pp. 600 - 604
Main Authors:	Loffeld, R.J.L.F., Fijen, C.A.P.M.J.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Elsevier Ltd 01-07-2003 Blackwell Science Ltd Blackwell
Subjects:	Anti-Bacterial Agents - pharmacology Antibacterial agents antibiotic resistance Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences clarithromycin Clarithromycin - pharmacology Drug Resistance, Bacterial - physiology Endoscopy, Gastrointestinal H. pylori Helicobacter Infections - diagnosis Helicobacter pylori Helicobacter pylori - drug effects Humans Medical sciences metronidazole Metronidazole - pharmacology Netherlands - epidemiology Netherlands - ethnology Pharmacology. Drug treatments Retrospective Studies Netherlands H. pylori metronidazole clarithromycin antibiotic resistance Human Nitro compound Imidazole derivatives Clarithromycin Spirillales Drug susceptibility test Spirillaceae Macrolide Ethnic group Resistance Antibiotic Antifungal agent Helicobacter pylori Cross sectional study Parasiticid Bacteria Metronidazole Antibacterial agent Clinical isolate Comparative study
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Summary:	To assess primary antibiotic resistance in a given population and relate the results to ethnicity. Consecutive cultures were tested for antibiotic susceptibility with the Etest. Three populations were studied separately: ethnic Dutch people, patients of Turkish descent, and patients originating from Africa and the Middle East. Over a period of 5.5 years, 976 (32%) biopsy specimens from 3010 patients were positive for Helicobacter pylori. Metronidazole and clarithromycin resistance were present in 25.8% and 4.8% of the strains, respectively. The number of metronidazole-resistant strains showed a gradual decrease, while clarithromycin resistance showed a slight increase during the study period. Antimicrobial resistance in patients of Turkish descent and in those originating from Africa or the Middle East was significantly higher than in ethnic Dutch people, 35% and 9.1% versus 21% and 2.9%, respectively (P = 0.003 and P = 0.002). It is important to take ethnicity into account when studying antibiotic resistance. The numbers of metronidazole- and clarithromycin-resistant strains can vary considerably between people of different ethnic origin living in the same region.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1198-743X 1469-0691
DOI:	10.1046/j.1469-0691.2003.00553.x