Search Results - "Figueiredo, Taiza H."
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Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy
Published in Neurobiology of disease (01-01-2020)“…One of the devastating effects of acute exposure to organophosphates, like nerve agents, is the induction of severe and prolonged status epilepticus (SE),…”
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Alterations in GABAA receptor-mediated inhibition triggered by status epilepticus and their role in epileptogenesis and increased anxiety
Published in Neurobiology of disease (01-10-2024)“…The triggers of status epilepticus (SE) in non-epileptic patients can vary widely, from idiopathic causes to exposure to chemoconvulsants. Regardless of its…”
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Reduced GABAergic inhibition in the basolateral amygdala and the development of anxiety-like behaviors after mild traumatic brain injury
Published in PloS one (21-07-2014)“…Traumatic brain injury (TBI) is a major public health concern affecting a large number of athletes and military personnel. Individuals suffering from a TBI…”
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α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology
Published in Molecules (Basel, Switzerland) (12-11-2015)“…α-Linolenic acid (ALA) is a nutraceutical found in vegetable products such as flax and walnuts. The pleiotropic properties of ALA target endogenous…”
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ASIC1a activation enhances inhibition in the basolateral amygdala and reduces anxiety
Published in The Journal of neuroscience (26-02-2014)“…The discovery that even small changes in extracellular acidity can alter the excitability of neuronal networks via activation of acid-sensing ion channels…”
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Mechanisms of Organophosphate Toxicity and the Role of Acetylcholinesterase Inhibition
Published in Toxics (Basel) (01-10-2023)“…Organophosphorus compounds (OPs) have applications in agriculture (e.g., pesticides), industry (e.g., flame retardants), and chemical warfare (nerve agents)…”
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Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus
Published in Toxics (Basel) (22-07-2022)“…Acute exposure to nerve agents induces status epilepticus (SE), which can cause death or long-term brain damage. Diazepam is approved by the FDA for the…”
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Repeated Isoflurane Exposures Impair Long-Term Potentiation and Increase Basal GABAergic Activity in the Basolateral Amygdala
Published in Neural plasticity (01-01-2016)“…After surgery requiring general anesthesia, patients often experience emotional disturbances, but it is unclear if this is due to anesthetic exposure. In the…”
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Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures
Published in Neuropharmacology (15-12-2020)“…Nerve agents are organophosphorus acetylcholinesterase inhibitors. Acute exposure to nerve agents can cause rapid death. In this review, we summarize the…”
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Acute and long‐term consequences of exposure to organophosphate nerve agents in humans
Published in Epilepsia (Copenhagen) (01-10-2018)“…Summary Nerve agents are organophosphate (OP) compounds and among the most powerful poisons known to man. A terrorist attack on civilian or military…”
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Increased inhibitory activity in the basolateral amygdala and decreased anxiety during estrus: A potential role for ASIC1a channels
Published in Brain research (01-11-2021)“…•Rhythmic spontaneous IPSCs in the basolateral amygdala (BLA) increase in estrus.•Anxiety-like behavior decreases in estrus.•Lower temperature enhances sIPSCs;…”
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Alterations in GABA A receptor-mediated inhibition triggered by status epilepticus and their role in epileptogenesis and increased anxiety
Published in Neurobiology of disease (01-10-2024)“…The triggers of status epilepticus (SE) in non-epileptic patients can vary widely, from idiopathic causes to exposure to chemoconvulsants. Regardless of its…”
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13
Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure
Published in Experimental biology and medicine (Maywood, N.J.) (01-04-2023)“…Prolonged status epilepticus (SE) can cause brain damage; therefore, treatment must be administered promptly after seizure onset to limit SE duration and…”
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Alpha-linolenic acid enhances the facilitation of GABAergic neurotransmission in the BLA and CA1
Published in Experimental biology and medicine (Maywood, N.J.) (01-04-2023)“…Hyperexcitability is a major mechanism implicated in several neuropsychiatric disorders, such as organophosphate-induced status epilepticus (SE), primary…”
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Preventing Long-Term Brain Damage by Nerve Agent-Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel Combined with Caramiphen but Not by Midazolam Treatment
Published in The Journal of pharmacology and experimental therapeutics (01-02-2024)“…Acute exposure to nerve agents induces a peripheral cholinergic crisis and prolonged status epilepticus (SE), causing death or long-term brain damage. To…”
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GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury
Published in Experimental neurology (01-11-2015)“…Patients that suffer mild traumatic brain injuries (mTBI) often develop cognitive impairments, including memory and learning deficits. The hippocampus shows a…”
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Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors
Published in Neuroscience (01-03-2018)“…•Rhythmic (0.5 Hz) spontaneous IPSC bursts in principal basolateral amygdala (BLA) neurons were blocked by AP5.•Rhythmic (0.5 Hz) spontaneous EPSC bursts in…”
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The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302
Published in The Journal of pharmacology and experimental therapeutics (01-11-2014)“…Exposure to nerve agents induces prolonged status epilepticus (SE), causing brain damage or death. Diazepam (DZP) is the current US Food and Drug…”
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Electroencephalographic analysis in soman‐exposed 21‐day‐old rats and the effects of midazolam or LY293558 with caramiphen
Published in Annals of the New York Academy of Sciences (01-11-2020)“…Acute nerve agent exposure induces status epilepticus (SE), which can cause brain damage or death. Research aiming at developing effective therapies for…”
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GABAergic circuits of the basolateral amygdala and generation of anxiety after traumatic brain injury
Published in Amino acids (01-09-2022)“…Traumatic brain injury (TBI) has reached epidemic proportions around the world and is a major public health concern in the United States. Approximately 2.8…”
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