Epithelial‐mesenchymal transition and microRNAs: Challenges and future perspectives in oral cancer

Epithelial‐mesenchymal transition and microRNAs: Challenges and future perspectives in oral cancer

Background Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial‐mesenchymal transition is emerging as a hallmark in OSCC. Met...

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Bibliographic Details
Published in:Head & neck Vol. 40; no. 10; pp. 2304 - 2313
Main Authors: Domingues, Cátia Sofia da Costa, Serambeque, Beatriz Prazeres, Laranjo Cândido, Mafalda Sofia, Marto, Carlos Miguel Machado, Veiga, Francisco José de Baptista, Sarmento Antunes Cruz Ribeiro, Ana Bela, Figueiras, Ana Rita Ramalho, Botelho, Maria Filomena Roque, Dourado, Marília de Assunção Rodrigues Ferreira
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-10-2018
Wiley Subscription Services, Inc
Subjects:
Cancer
epigenetic(s)
epithelial‐mesenchymal interactions
gene therapy/therapeutics
Head & neck cancer
Hydrophobicity
Mesenchyme
MicroRNAs
miRNA
Morbidity
nanotechnology
Oral cancer
oral carcinogenesis
Oral squamous cell carcinoma
Public health
Squamous cell carcinoma
Therapeutic applications
nanotechnology
epithelial-mesenchymal interactions
epigenetic(s)
oral carcinogenesis
gene therapy/therapeutics
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Summary:Background Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial‐mesenchymal transition is emerging as a hallmark in OSCC. Methods In this study, we described the role of microRNAs in epithelial‐mesenchymal transition regulation in OSCC based on a PubMed search using articles published in English between January 1, 2010, and January 31, 2018. Results MicroRNA's regulatory networks seem to be a hallmark of epithelial‐mesenchymal transition in OSCC pathophysiology becoming a growing challenge to design new studies and strategies from biology to clinical applications. Conclusion Therefore, we propose that targeting therapies to epithelial‐mesenchymal transition‐type cells, namely, coordinating microRNAs and/or hydrophobic drugs, such as conventional therapy, could be a promising strategy to improve the outcomes of patients with OSCC.
Bibliography:Section Editor: Robert L. Ferris, MD, PhD
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25381