Search Results - "Figliuzzi, Matteo"

How Pairwise Coevolutionary Models Capture the Collective Residue Variability in Proteins? by Figliuzzi, Matteo, Barrat-Charlaix, Pierre, Weigt, Martin

“…Abstract Global coevolutionary models of homologous protein families, as constructed by direct coupling analysis (DCA), have recently gained popularity in…”
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Inverse statistical physics of protein sequences: a key issues review by Cocco, Simona, Feinauer, Christoph, Figliuzzi, Matteo, Monasson, Rémi, Weigt, Martin

“…In the course of evolution, proteins undergo important changes in their amino acid sequences, while their three-dimensional folded structure and their…”
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Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1 by Figliuzzi, Matteo, Jacquier, Hervé, Schug, Alexander, Tenaillon, Oliver, Weigt, Martin

“…The quantitative characterization of mutational landscapes is a task of outstanding importance in evolutionary and medical biology: It is, for example, of…”
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An evolution-based model for designing chorismate mutase enzymes by Russ, William P, Figliuzzi, Matteo, Stocker, Christian, Barrat-Charlaix, Pierre, Socolich, Michael, Kast, Peter, Hilvert, Donald, Monasson, Remi, Cocco, Simona, Weigt, Martin, Ranganathan, Rama

“…The rational design of enzymes is an important goal for both fundamental and practical reasons. Here, we describe a process to learn the constraints for…”
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MicroRNAs as a Selective Channel of Communication between Competing RNAs: a Steady-State Theory by Figliuzzi, Matteo, Marinari, Enzo, De Martino, Andrea

“…It has recently been suggested that the competition for a finite pool of microRNAs (miRNA) gives rise to effective interactions among their common targets…”
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Probing the Limits to MicroRNA-Mediated Control of Gene Expression by Martirosyan, Araks, Figliuzzi, Matteo, Marinari, Enzo, De Martino, Andrea

“…According to the 'ceRNA hypothesis', microRNAs (miRNAs) may act as mediators of an effective positive interaction between long coding or non-coding RNA…”
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A multi-scale coevolutionary approach to predict interactions between protein domains by Croce, Giancarlo, Gueudré, Thomas, Ruiz Cuevas, Maria Virginia, Keidel, Victoria, Figliuzzi, Matteo, Szurmant, Hendrik, Weigt, Martin

“…Interacting proteins and protein domains coevolve on multiple scales, from their correlated presence across species, to correlations in amino-acid usage…”
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Molecular tools for the genomic assessment of oocyte’s reproductive competence by Picchetta, Ludovica, Caroselli, Silvia, Figliuzzi, Matteo, Cogo, Francesco, Zambon, Paola, Costa, Martina, Pergher, Ilaria, Patassini, Cristina, Cortellessa, Fabiana, Zuccarello, Daniela, Poli, Maurizio, Capalbo, Antonio

“…The most important factor associated with oocytes’ developmental competence has been widely identified as the presence of chromosomal abnormalities. However,…”
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Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1 by Birgy, André, Magnan, Mélanie, Hobson, Claire Amaris, Figliuzzi, Matteo, Panigoni, Karine, Codde, Cyrielle, Tenaillon, Olivier, Jacquier, Hervé

“…Due to their rapid evolution and their impact on healthcare, beta-lactamases, protein degrading beta-lactam antibiotics, are used as generic models of protein…”
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A scalable algorithm to explore the Gibbs energy landscape of genome-scale metabolic networks by De Martino, Daniele, Figliuzzi, Matteo, De Martino, Andrea, Marinari, Enzo

“…The integration of various types of genomic data into predictive models of biological networks is one of the main challenges currently faced by computational…”
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Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial by Capalbo, Antonio, Poli, Maurizio, Rienzi, Laura, Girardi, Laura, Patassini, Cristina, Fabiani, Marco, Cimadomo, Danilo, Benini, Francesca, Farcomeni, Alessio, Cuzzi, Juliana, Rubio, Carmen, Albani, Elena, Sacchi, Laura, Vaiarelli, Alberto, Figliuzzi, Matteo, Findikli, Necati, Coban, Onder, Boynukalin, Fazilet K., Vogel, Ivan, Hoffmann, Eva, Livi, Claudia, Levi-Setti, Paolo E., Ubaldi, Filippo M., Simón, Carlos

“…Chromosome imbalance (aneuploidy) is the major cause of pregnancy loss and congenital disorders in humans. Analyses of small biopsies from human embryos…”
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Improving landscape inference by integrating heterogeneous data in the inverse Ising problem by Barrat-Charlaix, Pierre, Figliuzzi, Matteo, Weigt, Martin

“…The inverse Ising problem and its generalizations to Potts and continuous spin models have recently attracted much attention thanks to their successful…”
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RNA-Based Regulation: Dynamics and Response to Perturbations of Competing RNAs by Figliuzzi, Matteo, De Martino, Andrea, Marinari, Enzo

“…The observation that, through a titration mechanism, microRNAs (miRNAs) can act as mediators of effective interactions among their common targets (competing…”
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BIOLOGICAL AND MOLECULAR MECHANISMS BEHIND PLOIDY ABNORMALITIES DETECTED IN BLASTOCYST STAGE EMBRYOS USING AN NGS BASED PGT-A PLATFORM WITH GENOTYPING DATA by Picchetta, Ludovica, Figliuzzi, Matteo, Zhan, Yiping, Caroselli, Silvia, Tao, Xin, Jalas, Chaim, Ottolini, Christian S., Mounts, Emily L., Capalbo, Antonio

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Implementing preconception expanded carrier screening in a universal health care system: A model-based cost-effectiveness analysis by Busnelli, Andrea, Ciani, Oriana, Caroselli, Silvia, Figliuzzi, Matteo, Poli, Maurizio, Levi-Setti, Paolo Emanuele, Tarricone, Rosanna, Capalbo, Antonio

“…PURPOSEThe limited evidence available on the cost-effectiveness (CE) of expanded carrier screening (ECS) prevents its widespread use in most countries,…”
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The use of copy number loads to designate mosaicism in blastocyst stage PGT-A cycles: fewer is better by Girardi, Laura, Figliuzzi, Matteo, Poli, Maurizio, Serdarogullari, Munevver, Patassini, Cristina, Caroselli, Silvia, Pergher, Ilaria, Cogo, Francesco, Coban, Onder, Boynukalin, Fazilet Kubra, Bahceci, Mustafa, Navarro, Roser, Rubio, Carmen, Findikli, Necati, Simón, Carlos, Capalbo, Antonio

“…Abstract STUDY QUESTION How well can whole chromosome copy number analysis from a single trophectoderm (TE) biopsy predict true mosaicism configurations in…”
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Human embryos with segmental aneuploidies display delayed early development: a multi-centre morphokinetic analysis by Figliuzzi, Matteo, Bori, Lorena, Ottolini, Christian Simon, Picchetta, Ludovica, Caroselli, Silvia, Reverenna, Marco, Poli, Maurizio, Campbell, Alison, Smith, Rachel, Coticchio, Giovanni, Cimadomo, Danilo, Rienzi, Laura Francesca, Meseguer, Marcos, Capalbo, Antonio

“…To assess if segmental aneuploid embryos display unique morphokinetic patterns DESIGN: Retrospective multicentre study including a total of 7,027 embryos…”
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Human embryos with segmental aneuploidies display delayed early development: a multicenter morphokinetic analysis by Figliuzzi, Matteo, Bori, Lorena, Ottolini, Christian Simon, Picchetta, Ludovica, Caroselli, Silvia, Reverenna, Marco, Poli, Maurizio, Campbell, Alison, Smith, Rachel, Coticchio, Giovanni, Cimadomo, Danilo, Rienzi, Laura Francesca, Meseguer, Marcos, Capalbo, Antonio

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Identification of Protein Functional Regions by Nerattini, Francesca, Figliuzzi, Matteo, Cardelli, Chiara, Tubiana, Luca, Bianco, Valentino, Dellago, Christoph, Coluzza, Ivan

“…Protein sequence stores the information relative to both functionality and stability, thus making it difficult to disentangle the two contributions. However,…”
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An evolution-based model for designing chorismate mutase enzymes by Russ, William, Figliuzzi, Matteo, Stocker, Christian, Barrat-Charlaix, Pierre, Socolich, Michael, Kast, Peter, Hilvert, Donald, Monasson, Remi, Cocco, Simona, Weigt, Martin, Ranganathan, Rama

“…The rational design of enzymes is an important goal for both fundamental and practical reasons. Here, we describe a process to learn the constraints for…”
Get full text