Search Results - "Figler, Robert A."

Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk by Feaver, Ryan E, Bowers, M. Scott, Cole, Banumathi K, Hoang, Steve, Lawson, Mark J, Taylor, Justin, LaMoreaux, Brian D, Zhao, Lin, Henke, Brad R, Johns, Brian A, Nyborg, Andrew C, Wamhoff, Brian R, Figler, Robert A

“…Some health concerns are often not identified until late into clinical development of drugs, which can place participants and patients at significant risk. For…”
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The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells by Wilson, Jeffrey M, Ross, William G, Agbai, Oma N, Frazier, Renea, Figler, Robert A, Rieger, Jayson, Linden, Joel, Ernst, Peter B

“…The endogenous purine nucleoside adenosine is an important antiinflammatory mediator that contributes to the control of CD4(+) T cell responses. While…”
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Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response by Roller, Devin G., Hoang, Stephen A., Rawls, Kristopher D., Owen, Katherine A., Simmers, Michael B., Figler, Robert A., Wulfkuhle, Julia D., Petricoin, Emanuel F., Wamhoff, Brian R., Gioeli, Daniel

“…Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs…”
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Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans by FIGLER, Robert A, GUOQUAN WANG, KIM, Jason K, LANOUE, Kathryn F, LINDEN, Joel, SRINIVASAN, Susseela, DAE YOUNG JUNG, ZHIYOU ZHANG, PANKOW, James S, RAVID, Katya, FREDHOLM, Bertil, HEDRICK, Catherine C, RICH, Stephen S

“…To determine the mechanisms by which blockade of adenosine A(2B) receptors (A(2B)Rs) reduces insulin resistance. We investigated the effects of deleting or…”
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Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis by Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.

“…Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared…”
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Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes by Collado, Maria S., Cole, Banumathi K., Figler, Robert A., Lawson, Mark, Manka, David, Simmers, Michael B., Hoang, Steve, Serrano, Felipe, Blackman, Brett R., Sinha, Sanjay, Wamhoff, Brian R.

“…Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial (iEC) and smooth muscle (iSMC) cells. However, because iECs and…”
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Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein by Al-Shawi, Marwan K., Polar, Mark K., Omote, Hiroshi, Figler, Robert A.

“…ATPase activity associated with P-glycoprotein (Pgp) is characterized by three drug-dependent phases: basal (no drug), drug-activated, and drug-inhibited. To…”
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Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment by Li, Yuesheng, Figler, Robert A, Kolling, Glynis, Bracken, Tara C, Rieger, Jayson, Stevenson, Ralph W, Linden, Joel, Guerrant, Richard L, Warren, Cirle Alcantara

“…Activation of the A2A adenosine receptor (A2AAR) decreases production of inflammatory cytokines, prevents C. difficile toxin A-induced enteritis and, in…”
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Drug-induced steatohepatitis by Dash, Ajit, Figler, Robert A, Sanyal, Arun J, Wamhoff, Brian R

“…Drug induced steatohepatitis (DISH), a form of drug induced liver injury (DILI) is characterized by intracellular accumulation of lipids in hepatocytes and…”
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Biochemical and anaplerotic applications of in vitro models of propionic acidemia and methylmalonic acidemia using patient-derived primary hepatocytes by Collado, M. Sol, Armstrong, Allison J., Olson, Matthew, Hoang, Stephen A., Day, Nathan, Summar, Marshall, Chapman, Kimberly A., Reardon, John, Figler, Robert A., Wamhoff, Brian R.

“…Propionic acidemia (PA) and methylmalonic acidemia (MMA) are autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, which are caused by a…”
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Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells by Gioeli, Daniel, Snow, Chelsi J, Simmers, Michael B, Hoang, Stephen A, Figler, Robert A, Allende, J Ashe, Roller, Devin G, Parsons, J Thomas, Wulfkuhle, Julia D, Petricoin, Emanuel F, Bauer, Todd W, Wamhoff, Brian R

“…The development of drugs to treat cancer is hampered by the inefficiency of translating pre-clinical in vitro monoculture and mouse studies into clinical…”
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Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia by Armstrong, Allison J, Henke, Brad R, Collado, Maria Sol, Taylor, Justin M, Pourtaheri, Taylor D, Dillberger, John E, Roper, Thomas D, Wamhoff, Brian R, Olson, Matthew W, Figler, Robert A, Hoang, Stephen A, Reardon, John E, Johns, Brian A

“…Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in…”
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A novel small molecule approach for the treatment of propionic and methylmalonic acidemias by Armstrong, Allison J., Collado, Maria Sol, Henke, Brad R., Olson, Matthew W., Hoang, Stephen A., Hamilton, Christin A., Pourtaheri, Taylor D., Chapman, Kimberly A., Summar, Marshall M., Johns, Brian A., Wamhoff, Brian R., Reardon, John E., Figler, Robert A.

“…Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine…”
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Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis by Feaver, Ryan E, Cole, Banumathi K, Lawson, Mark J, Hoang, Stephen A, Marukian, Svetlana, Blackman, Brett R, Figler, Robert A, Sanyal, Arun J, Wamhoff, Brian R, Dash, Ajit

“…A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of translational preclinical human-relevant systems. An in vitro liver…”
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Links between insulin resistance, adenosine [A.sub.2B] receptors, and inflammatory markers in mice and Humans.(ORIGINAL ARTICLE) by Figler, Robert A, Wang, Guoquan, Srinivasan, Susseela, Jung, Dae Young, Zhang, Zhiyou, Pankow, James S, Ravid, Katya, Fredholm, Bertil, Hedrick, Catherine C, Rich, Stephen S, Kim, Jason K, LaNoue, Kathryn F, Linden, Joel

“…OBJECTIVE--To determine the mechanisms by which blockade of adenosine [A.sub.2B] receptors ([A.sub.2]BRS) reduces insulin resistance. RESEARCH DESIGN AND…”
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Genomic and biochemical analysis of repeatedly observed variants in DBT in individuals with maple syrup urine disease of Central American ancestry by Billington, Charles J., Chapman, Kimberly A., Leon, Eyby, Meltzer, Beatrix W., Berger, Seth I., Olson, Matthew, Figler, Robert A., Hoang, Steve A., Wanxing, Cui, Wamhoff, Brian R., Collado, M. Sol, Cusmano‐Ozog, Kristina

“…Maple syrup urine disease (MSUD) is an intoxication‐type inherited metabolic disorder in which hyperleucinemia leads to brain swelling and death without…”
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Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes by Terelius, Ylva, Figler, Robert A., Marukian, Svetlana, Collado, Maria S., Lawson, Mark J., Mackey, Aaron J., Manka, David, Qualls, Charles W., Blackman, Brett R., Wamhoff, Brian R., Dash, Ajit

“…Drug induced liver injury (DILI), a major cause of pre- and post-approval failure, is challenging to predict pre-clinically due to varied underlying direct and…”
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An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation by Cole, Banumathi K, Simmers, Michael B, Feaver, Ryan, Qualls, Jr, Charles W, Collado, M Sol, Berzin, Erica, Figler, Robert A, Pryor, Jr, Andrew W, Lawson, Mark, Mackey, Aaron, Manka, David, Wamhoff, Brian R, Turk, James R, Blackman, Brett R

“…The predictive value of animal and in vitro systems for drug development is limited, particularly for nonhuman primate studies as it is difficult to deduce the…”
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Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection by Warren, Cirle A, Li, Yuesheng, Calabrese, Gina M, Freire, Rosemayre S, Zaja-Milatovic, Snjezana, van Opstal, Edward, Figler, Robert A, Linden, Joel, Guerrant, Richard L

“…Clostridium difficile toxins A (TcdA) and B (TcdB) induce a pronounced systemic and intestinal inflammatory response. A(2B) adenosine receptors (A(2B)ARs) are…”
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Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes by Chapman, Kimberly A., Collado, Maria S., Figler, Robert A., Hoang, Stephen A., Armstrong, Allison J., Cui, Wanxing, Purdy, Michael, Simmers, Michael B., Yazigi, Nada A., Summar, Marshall L., Wamhoff, Brian R., Dash, Ajit

“…Propionic acidemia (PA) is a disorder of intermediary metabolism with defects in the alpha or beta subunits of propionyl CoA carboxylase (PCCA and PCCB…”
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