Search Results - "Figeac, Nicolas"
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DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts
Published in Scientific reports (19-05-2022)“…WNT signalling is essential for regulating a diverse range of cellular processes. In skeletal muscle, the WNT pathway plays crucial roles in maintenance of the…”
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Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture
Published in PloS one (17-09-2018)“…Biophysical/biochemical cues from the environment contribute to regulation of the regenerative capacity of resident skeletal muscle stem cells called…”
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VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle
Published in Journal of cell science (01-07-2019)“…VGLL proteins are transcriptional co-factors that bind TEAD family transcription factors to regulate events ranging from wing development in fly, to muscle…”
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ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells
Published in Developmental biology (01-02-2014)“…Satellite cells are resident stem cells of skeletal muscle, supplying myoblasts for post-natal muscle growth, hypertrophy and repair. Many regulatory networks…”
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Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular Dystrophy
Published in Frontiers in cell and developmental biology (07-09-2022)“…Aberrant expression of the transcription factor DUX4 from D4Z4 macrosatellite repeats on chromosome 4q35, and its transcriptome, associate with pathogenesis in…”
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Muscle development and regeneration in normal and pathological conditions: learning from Drosophila
Published in Current pharmaceutical design (01-03-2010)“…The recent demonstration that, throughout evolution, many molecular mechanisms have been highly conserved is fundamental to the advancement of our knowledge on…”
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Specification and behavior of AMPs, muscle-committed transient Drosophila stem cells
Published in Fly (Austin, Tex.) (01-01-2011)“…During development, transient stem cells play critical roles in the formation of specific tissues. Adult Muscle Precursors (AMPs) are at the origin of all…”
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Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function
Published in Cellular signalling (01-08-2015)“…The resident stem cells of skeletal muscle are satellite cells, which are regulated by both canonical and non-canonical Wnt pathways. Canonical Wnt signalling…”
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Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophy
Published in Human molecular genetics (15-04-2019)“…Abstract Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, incurable myopathy, linked to epigenetic derepression of D4Z4 repeats on chromosome 4q,…”
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10
Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy
Published in Acta neuropathologica (01-09-2019)“…Nemaline myopathy (NM) is a skeletal muscle disorder caused by mutations in genes that are generally involved in muscle contraction, in particular those…”
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Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway
Published in Development (Cambridge) (15-06-2010)“…In Drosophila, a population of muscle-committed stem-like cells called adult muscle precursors (AMPs) keeps an undifferentiated and quiescent state during…”
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Pitx genes are redeployed in adult myogenesis where they can act to promote myogenic differentiation in muscle satellite cells
Published in Developmental biology (01-05-2013)“…Skeletal muscle retains a resident stem cell population called satellite cells. Although mitotically quiescent in mature muscle, satellite cells can be…”
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Muscle stem cells and model systems for their investigation
Published in Developmental dynamics (01-12-2007)“…Stem cells are characterized by their clonal ability both to generate differentiated progeny and to undergo self‐renewal. Studies of adult mammalian organs…”
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DEPDC1B is a key regulator of myoblast proliferation in mouse and man
Published in Cell proliferation (01-01-2020)“…Objectives DISHEVELLED, EGL‐10, PLECKSTRIN (DEP) domain‐containing 1B (DEPDC1B) promotes dismantling of focal adhesions and coordinates detachment events…”
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Sphingosine-1-phosphate receptor 3 influences cell cycle progression in muscle satellite cells
Published in Developmental biology (15-10-2013)“…Skeletal muscle retains a resident stem cell population called satellite cells, which are mitotically quiescent in mature muscle, but can be activated to…”
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