Search Results - "Figarska, Sylwia"
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Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction
Published in European journal of heart failure (01-06-2021)“…Aims The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of…”
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Effects of empagliflozin on renal sodium and glucose handling in patients with acute heart failure
Published in European journal of heart failure (01-01-2021)“…Aims Sodium–glucose co‐transporter 2 (SGLT2) inhibitors improve clinical outcome in patients with heart failure (HF), but the mechanisms behind their…”
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The genomic origins of the world’s first farmers
Published in Cell (26-05-2022)“…The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their…”
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SIRT1 polymorphism, long-term survival and glucose tolerance in the general population
Published in PloS one (07-03-2013)“…Mutations that increase activity of Sir2 (silent information regulator 2) are associated with extended lifespan of yeast, fruit flies and worms. SIRT1, the…”
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Worsening renal function in acute heart failure in the context of diuretic response
Published in European journal of heart failure (01-02-2022)“…Background For patients with acute heart failure (AHF), substantial diuresis after administration of loop diuretics is generally associated with better…”
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Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention
Published in Scientific reports (13-05-2020)“…Inflammatory and cardiovascular biomarkers have been associated with obesity, but little is known about how they change upon dietary intervention and…”
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NFE2L2 polymorphisms, mortality, and metabolism in the general population
Published in Physiological genomics (15-06-2014)“…The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) gene regulates transcription of enzymes involved in cellular detoxification and lipids…”
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Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure
Published in European journal of heart failure (01-02-2022)“…Aims Elevated concentrations of growth differentiation factor 15 (GDF‐15) in patients with heart failure (HF) have been consistently associated with worse…”
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Multiomics Analysis Provides Novel Pathways Related to Progression of Heart Failure
Published in Journal of the American College of Cardiology (14-11-2023)“…BACKGROUNDDespite major advances in pharmacological treatment for patients with heart failure, residual mortality remains high. This suggests that important…”
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Dyspnea severity, changes in dyspnea status and mortality in the general population: the Vlagtwedde/Vlaardingen study
Published in European journal of epidemiology (01-11-2012)“…Dyspnea is a predictor of mortality. The effects of dyspnea severity and changes in dyspnea status on all-cause and cause-specific mortality remain unclear…”
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High throughput image processing software for analyzing hiPSC-CM sarcomere physiology and cardiac fibroblast activation
Published in Biophysical journal (10-02-2023)Get full text
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Associations of Circulating Protein Levels With Lipid Fractions in the General Population
Published in Arteriosclerosis, thrombosis, and vascular biology (01-10-2018)“…OBJECTIVE—Revealing patterns of associations between circulating protein and lipid levels could improve biological understanding of cardiovascular disease…”
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Changes in Proteomic Profiles are Related to Changes in BMI and Fat Distribution During 10 Years of Aging
Published in Obesity (Silver Spring, Md.) (01-01-2020)“…Objective This study investigated how changes in 84 proteins over a 10‐year period of aging were related to changes in measures of body fat and distribution…”
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Distinct Comorbidity Clusters in Patients With Acute Heart Failure: Data From RELAX-AHF-2
Published in JACC. Heart failure (01-10-2024)“…Multimorbidity frequently occurs in patients with acute heart failure (AHF). The co-occurrence of comorbidities often follows specific patterns. This study…”
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ADAM33 gene polymorphisms and mortality. A prospective cohort study
Published in PloS one (04-07-2013)“…The ADAM33 gene is associated with the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. In this study we investigated…”
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Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
Published in Clinical research in cardiology (01-08-2023)“…Background Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol…”
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Dyspnea severity, changes in dyspnea status and mortality in the general population: the Vlagtwedde/Vlaardingen study
Published in European journal of epidemiology (01-11-2012)Get full text
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18
Abstract P2160: High-throughput Imaging Of Cardiomyocytes Using Biomimetic Tools Help Identify Therapeutic Targets
Published in Circulation research (04-08-2023)“…Abstract only Cardiovascular disease is a leading cause of death and continues to require novel forms of therapies. Mutations in sarcomeres, the basic…”
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CHANGES IN PROTEOMIC PROFILES ARE RELATED TO CHANGES IN BODY MASS INDEX AND FAT DISTRIBUTION DURING TEN YEARS OF AGING
Published in Obesity (Silver Spring, Md.) (05-12-2019)Get full text
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20
Multi-omics analysis provides novel pathways related to progression of heart failure
Published in Journal of the American College of Cardiology (14-11-2023)Get full text
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