Search Results - "Fieux, Sylvain"

Oxytocin and Serotonin Brain Mechanisms in the Nonhuman Primate by Lefevre, Arthur, Richard, Nathalie, Jazayeri, Mina, Beuriat, Pierre-Aurélien, Fieux, Sylvain, Zimmer, Luc, Duhamel, Jean-René, Sirigu, Angela

“…Oxytocin (OT) is increasingly studied for its therapeutic potential in psychiatric disorders, which are associated with the deregulation of several…”
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[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations by Colom, Matthieu, Vidal, Benjamin, Fieux, Sylvain, Redoute, Jérôme, Costes, Nicolas, Lavenne, Franck, Mérida, Inés, Irace, Zacharie, Iecker, Thibaud, Bouillot, Caroline, Billard, Thierry, Newman-Tancredi, Adrian, Zimmer, Luc

“…Introduction Serotonin is involved in a variety of physiological functions and brain disorders. In this context, efforts have been made to investigate the in…”
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Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors by Sgambato-Faure, Véronique, Billard, Thierry, Météreau, Elise, Duperrier, Sandra, Fieux, Sylvain, Costes, Nicolas, Tremblay, Léon, Zimmer, Luc

“…Brain serotonin-6 receptor (5-HT 6 R) is the one of the most recently identified serotonin receptors. Accumulating evidence suggests that it is a potent…”
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PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats by Balasse, Laure, Maerk, Julia, Pain, Frédéric, Genoux, Aurelie, Fieux, Sylvain, Lefebvre, Françoise, Morel, Christian, Gisquet-Verrier, Pascale, Lanièce, Philippe, Zimmer, Luc

“…The aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission…”
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Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5‑HT6 Serotoninergic Receptors by Colomb, Julie, Becker, Guillaume, Fieux, Sylvain, Zimmer, Luc, Billard, Thierry

“…The 5-HT6 receptors are potent therapeutic targets for psychiatric and neurological diseases (schizophrenia, Alzheimer’s disease, etc.). However, with lack of…”
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In vivo biased agonism at 5-HT 1A receptors: characterisation by simultaneous PET/MR imaging by Vidal, Benjamin, Fieux, Sylvain, Redouté, Jérôme, Villien, Marjorie, Bonnefoi, Frédéric, Le Bars, Didier, Newman-Tancredi, Adrian, Costes, Nicolas, Zimmer, Luc

“…In neuropharmacology, the recent concept of 'biased agonism' denotes the capacity of certain agonists to target-specific intracellular pathways of a given…”
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Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer’s disease: A post-mortem study with PET radiopharmaceuticals by Vidal, Benjamin, Sebti, Johan, Verdurand, Mathieu, Fieux, Sylvain, Billard, Thierry, Streichenberger, Nathalie, Troakes, Claire, Newman-Tancredi, Adrian, Zimmer, Luc

“…PET imaging studies using 5-HT1A receptor radiotracers show a decreased density of this receptor in hippocampi of patients with Alzheimer’s disease (AD) at…”
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In vivo biased agonism at 5-HT1A receptors: characterisation by simultaneous PET/MR imaging by Vidal, Benjamin, Fieux, Sylvain, Redouté, Jérôme, Villien, Marjorie, Bonnefoi, Frédéric, Le Bars, Didier, Newman-Tancredi, Adrian, Costes, Nicolas, Zimmer, Luc

“…In neuropharmacology, the recent concept of 'biased agonism' denotes the capacity of certain agonists to target-specific intracellular pathways of a given…”
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Serotonin 5‑HT1A Receptor Biased Agonists Induce Different Cerebral Metabolic Responses: A [18F]-Fluorodesoxyglucose Positron Emission Tomography Study in Conscious and Anesthetized Rats by Levigoureux, Elise, Vidal, Benjamin, Fieux, Sylvain, Bouillot, Caroline, Emery, Stéphane, Newman-Tancredi, Adrian, Zimmer, Luc

“…Serotonin 5-HT1A receptors constitute an attractive therapeutic target for various psychiatric or neurodegenerative disorders. These receptors are expressed in…”
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Contribution of simultaneous PET-MRI to understanding the neuropharmacology of 5-HT^sub 1A^ receptor biased agonists by Vidal, Benjamin, Fieux, Sylvain, Villien, Marjorie, Bars, Didier Le, Newman-Tancredi, Adrian, Costes, Nicolas, Zimmer, Luc

“…Objectives: The recent neuropharmacological concept of "biased agonism" implies the capacity of highly specific agonists to target specific intracellular…”
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Preclinical validation of [18F]2FNQ1P as a specific PET radiotracer of 5-HT6 receptors in rat, pig, non-human primate and human brain tissue by Emery, Stéphane, Fieux, Sylvain, Vidal, Benjamin, Courault, Pierre, Bouvard, Sandrine, Tourvieille, Christian, Iecker, Thibaut, Billard, Thierry, Zimmer, Luc, Lancelot, Sophie

“…The aim of this study was to perform in-vitro and in-vivo radiopharmacological characterizations of [18F]2FNQ1P, a new PET radiotracer of 5-HT6 receptors, in…”
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Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5-HT 6 Serotoninergic Receptors by Colomb, Julie, Becker, Guillaume, Fieux, Sylvain, Zimmer, Luc, Billard, Thierry

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Serotonin 5-HT 1A Receptor Biased Agonists Induce Different Cerebral Metabolic Responses: A [ 18 F]-Fluorodesoxyglucose Positron Emission Tomography Study in Conscious and Anesthetized Rats by Levigoureux, Elise, Vidal, Benjamin, Fieux, Sylvain, Bouillot, Caroline, Emery, Stéphane, Newman-Tancredi, Adrian, Zimmer, Luc

“…Serotonin 5-HT receptors constitute an attractive therapeutic target for various psychiatric or neurodegenerative disorders. These receptors are expressed in…”
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[ 18 F]F13640, a 5-HT 1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations by Colom, Matthieu, Vidal, Benjamin, Fieux, Sylvain, Redoute, Jérôme, Costes, Nicolas, Lavenne, Franck, Mérida, Inés, Irace, Zacharie, Iecker, Thibaud, Bouillot, Caroline, Billard, Thierry, Newman-Tancredi, Adrian, Zimmer, Luc

“…Serotonin is involved in a variety of physiological functions and brain disorders. In this context, efforts have been made to investigate the fluctuations of…”
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Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI by Yankam Njiwa, J, Costes, N, Bouillot, C, Bouvard, S, Fieux, S, Becker, G, Levigoureux, E, Kocevar, G, Stamile, C, Langlois, JB, Bolbos, R, Bonnet, C, Bezin, L, Zimmer, L, Hammers, A

“…Inflammation may play a role in the development of epilepsy after brain insults. [11C]-(R)-PK11195 binds to TSPO, expressed by activated microglia. We…”
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[11C]PF-3274167 as a PET radiotracer of oxytocin receptors: Radiosynthesis and evaluation in rat brain by Vidal, Benjamin, Karpenko, Iuliia A., Liger, François, Fieux, Sylvain, Bouillot, Caroline, Billard, Thierry, Hibert, Marcel, Zimmer, Luc

“…Oxytocin plays a major role in the regulation of social interactions in mammals by interacting with the oxytocin receptor (OTR) expressed in the brain…”
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18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging by Vidal, Benjamin, Fieux, Sylvain, Colom, Matthieu, Billard, Thierry, Bouillot, Caroline, Barret, Olivier, Constantinescu, Cristian, Tamagnan, Gilles, Newman-Tancredi, Adrian, Zimmer, Luc

“…Serotonin 1A receptors are known to play an important role in many psychiatric and neurodegenerative disorders. Currently, all available 5-HT 1A receptor PET…”
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Preclinical validation of [ 18 F]2FNQ1P as a specific PET radiotracer of 5-HT 6 receptors in rat, pig, non-human primate and human brain tissue by Emery, Stéphane, Fieux, Sylvain, Vidal, Benjamin, Courault, Pierre, Bouvard, Sandrine, Tourvieille, Christian, Iecker, Thibaut, Billard, Thierry, Zimmer, Luc, Lancelot, Sophie

“…The aim of this study was to perform in-vitro and in-vivo radiopharmacological characterizations of [ F]2FNQ1P, a new PET radiotracer of 5-HT receptors, in…”
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Characterization and Reliability of [ 18 F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT 6 Receptors by Sgambato-Faure, Véronique, Billard, Thierry, Météreau, Elise, Duperrier, Sandra, Fieux, Sylvain, Costes, Nicolas, Tremblay, Léon, Zimmer, Luc

“…Brain serotonin-6 receptor (5-HT R) is the one of the most recently identified serotonin receptors. Accumulating evidence suggests that it is a potent…”
Get full text

18 F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT 1A receptor agonist for PET neuroimaging by Vidal, Benjamin, Fieux, Sylvain, Colom, Matthieu, Billard, Thierry, Bouillot, Caroline, Barret, Olivier, Constantinescu, Cristian, Tamagnan, Gilles, Newman-Tancredi, Adrian, Zimmer, Luc

“…Serotonin 1A receptors are known to play an important role in many psychiatric and neurodegenerative disorders. Currently, all available 5-HT receptor PET…”
Get full text