Search Results - "Fietto, Juliana"
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Concomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruzi
Published in Antimicrobial agents and chemotherapy (01-10-2015)“…Although suramin (Sur) is suggested as a potential drug candidate in the management of Chagas disease, this issue has not been objectively tested. In this…”
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Development of a new assay for quantification of parasite load of intracellular Leishmania sp. in macrophages using flow cytometry
Published in Cytometry. Part A (01-05-2024)“…Finding novel methodologies that enhance the precision, agility, and standardization of drug discovery is crucial for studying leishmaniasis. The slide count…”
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3
Proteomic and phosphoproteomic analyses reveal several events involved in the early stages of bovine herpesvirus 1 infection
Published in Archives of virology (2020)“…Herpesviruses are predicted to express more than 80 proteins during their infection cycle. The proteins synthesized by the immediate early genes and early…”
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Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
Published in PLoS neglected tropical diseases (01-10-2012)“…Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive…”
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Retrospective Detection and Genetic Characterization of Porcine circovirus 3 (PCV3) Strains Identified between 2006 and 2007 in Brazil
Published in Viruses (27-02-2019)“…3 (PCV3) is an emerging virus that was first identified in the United States in 2016. Since its first detection, PCV3 has already been found in America, Asia,…”
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Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents
Published in Bioorganic & medicinal chemistry letters (01-05-2020)“…[Display omitted] •The synthesis of novel 7-amino-thiazolo[5,4-d]pyrimidine derivatives is reported.•Compounds were tested for their affinity and potency at…”
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Synthesis and Evaluation of the Antileishmanial Activity of Novel Eugenol Analogs Containing 1,2,3-Triazole Fragments against Intracellular Leishmania braziliensis
Published in Journal of the Brazilian Chemical Society (2023)“…This investigation describes the synthesis of eugenol analogs presenting 1,2,3-triazole fragments and evaluation of their antileishmanial activity. The…”
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Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)
Published in PloS one (05-08-2015)“…Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of several diseases. The serine/arginine-rich protein kinase family…”
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porcine circovirus-2 mutant isolated in Brazil contains low-frequency substitutions in regions of immunoprotective epitopes in the capsid protein
Published in Archives of virology (01-11-2015)“…Porcine circovirus-2 (PCV2) is the etiologic agent of several diseases in pigs, including multi-systemic wasting syndrome (PMWS). In this work, a new mutant…”
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Urea, salts, and Tween 20 influence on adsorption of IgG and Leishmania rNTPDase2 to nitrocellulose
Published in Analytical biochemistry (01-06-2022)“…Lateral flow immunochromatography is a widely used technique for immunological assays. Construction of test and control lines is mostly done by antigen…”
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Evolutionary analysis of Porcine circovirus 3 (PCV3) indicates an ancient origin for its current strains and a worldwide dispersion
Published in Virus genes (01-06-2018)“…Porcine circovirus 3 (PCV3) is an emerging virus that was identified in the United States in 2016. Since its first identification, PCV3 has been identified in…”
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Tripping over emerging pathogens around the world: A phylogeographical approach for determining the epidemiology of Porcine circovirus-2 (PCV-2), considering global trading
Published in Virus research (01-01-2012)“…► We analyzed the main routes of the spread of PCV-2 between pig-producing countries. ► PCV-2 is widely distributed throughout pig-producing countries. ► Can.,…”
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Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice
Published in Oxidative medicine and cellular longevity (01-01-2018)“…Suramin (Sur) acts as an ecto-NTPDase inhibitor in Trypanosoma cruzi and a P2-purinoceptor antagonist in mammalian cells. Although the potent antitrypanosomal…”
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14
The SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl) isonicotinamide (SRPIN340) increases the immune response against metastatic melanoma in mice
Published in Biochemical pharmacology (01-09-2022)“…[Display omitted] Cancers have a strong relationship with immune cells in their microenvironment, which significantly influences tumor proliferation and…”
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Feline coronavirus isolates from a part of Brazil: insights into molecular epidemiology and phylogeny inferred from the 7b gene
Published in Journal of Veterinary Medical Science (2019)“…The Feline coronavirus (FCoV) can lead to Feline infectious peritonitis (FIP), which the precise cause is still unknown. The theory of internal mutation…”
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Antigens and their diagnostic performance for Canine Visceral Leishmaniasis: A critical review
Published in Veterinary parasitology (01-01-2022)“…Review developing steps were search strategy and article selection, data extraction, analysis and writing. On the analysis, several plots were constructed to…”
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Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence
Published in PLoS neglected tropical diseases (2009)“…The protozoan Trypanosoma cruzi is the causative agent of Chagas disease. There are no vaccines or effective treatment, especially in the chronic phase when…”
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Detection and partial molecular characterization of Picobirnavirus in swine from the state of Minas Gerais, Brazil
Published in Journal of Veterinary Medical Science (2020)“…Picobirnavirus (PBV) is a small two-segmented double-stranded RNA (dsRNA) virus that has been identified in diarrheic feces of a large range of animal hosts,…”
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Synthesis and antimetastatic activity evaluation of cinnamic acid derivatives containing 1,2,3-triazolic portions
Published in Toxicology in vitro (01-12-2018)“…It is herein described the preparation and evaluation of antimetastatic activity of twenty-six cinnamic acid derivatives containing 1,2,3-triazolic portions…”
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Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages
Published in Acta tropica (01-01-2023)“…•Overexpression of LiNTPDase1 and 2 has no effect on L. infantum morphology and growth rate.•CRISPR/Cas9-mediated genetic inactivation of LiNTPDase1 or…”
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